Washington Commanders vs Indianapolis Colts Prediction & Betting Tips - NFL

Prediction published on 02/10/2026, 09:30  by Matthew Newman | Modified on 03/10/2026 at 06:40 in NFL Predictions

The Washington Commanders will take on the Indianapolis Colts at the Tottenham Hotspur Stadium on Sunday afternoon in NFL action. Both teams come in with a 1-2 record in the early season. The Commanders arrive beaten up offensively, while their defensive strength counters the Colts offensive strength, so points look at a premium.

Marcus Mariota will start at quarterback for the Commanders with Jayden Daniels still out with a dislocated elbow sustained in week 2 against the Cowboys. Mariota led them to their first win of the season in week 3 against the defending Super Bowl champion, Seattle Seahawks.

Rachaad White will be missing for the Commanders at running back, while Terry McLaurin is questionable at wide receiver, two solid offensive options for them. The danger is that they won’t be able to back up that success. 

The Colts also got off the mark at the third time of asking, beating the Houston Texans last time out, 19-17. They had only got beaten in overtime the week before against the Kansas City Chiefs, 20-17 in front at half time on that occasion.

Their best attacking option comes from running back Jonathan Taylor who has four rushing touchdowns this season, with the team having seven overall. Only the Buccaneers and Falcons have given up fewer yards on the ground than the Commanders, however.