Napoli vs Pisa SC Prediction & Betting Tips - Serie A
Italy - Serie A
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by Sridhar Bhamidi | in Serie A Predictions
Napoli will put their 100% winning record of the 2025-26 Serie A campaign on the line on matchday four when they host Pisa on Monday. This match at Stadio Diego Armando Maradona between the league-leading Partenopei (nine points) and the 18th-placed Nerazzurri (one point) comes with our prediction of a home win and under 2.5 goals.
Ahead of this round, Napoli lead the standings over Juventus by goal difference. Pisa are one of the six sides yet to win a game after three rounds and are in the bottom three.
A 2-0 away defeat at Manchester City was a humbling experience for Napoli in the Champions League on Thursday. That halted a winning start to the campaign for the defending league champions.
Napoli have won all three of their league matches this year and kept a clean sheet in two of those. The lone exception came in a 3-1 away win over Fiorentina last weekend.
Pisa’s 34-year wait for Serie A action hasn’t gone to plan, although they started with a creditable 1-1 draw at Atalanta on matchday. Consecutive 1-0 defeats since then, including last weekend against Udinese, kept them waiting for their first win.
Both those losses have come at home, and Pisa will hope they can repeat the matchday one heroics again on the road.
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Napoli v Pisa SC Best Betting Odds
| Bookmaker | 1 | X | 2 | Bonus up to |
|---|---|---|---|---|
|
1.32 | 5.4 | 11 |
|
|
1.32 | 5.46 | 11 |
|
|
1.28 | 5.45 | 11 |
|
|
1.29 | 5.3 | 10.5 |
|
|
1.3 | 5.25 | 10 |
|
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What is the prediction for the football match between Napoli and Pisa SC?
Our prediction for the Napoli vs Pisa SC match is: Napoli win and under 2.5.
Probabilities according to our algorithm* of possible 1X2 football predictions and best odds for the match on 22/09/2025 between Napoli and Pisa SC in Serie A :
- The Sportytrader ⭐ algorithm estimates a probability of 57.25% for a win of Napoli against Pisa SC with odds of 1.35 at Betway.
- The probability according to Sportytrader ⭐ for a draw between Napoli vs Pisa SC is 26.11% with odds of 5.6 at Tonybet.
- Our prediction model gives a 16.64% chance ⭐ for a win of Pisa SC vs Napoli with odds of 13 at LSbet.
Napoli - Pisa SC Prediction and Best Odds:
| Napoli Pisa SC Prediction | Probability | Odds |
|---|---|---|
| Napoli wins | 57.25% | 1.35 at Betway |
| Over 2.5 goals | 51.96% | 2.01 at 1xbet |
| Both Team To Score | 52.38% | |
| Half-time / Full-time : Napoli/Napoli | 26.12% | 1.95 at Bet365 |
Napoli vs Pisa SC Form
Napoli and Pisa SC's standings in the Serie A
| Teams | Pts | P | W | D | L | GD |
|---|---|---|---|---|---|---|
|
2
|
76 | 38 | 23 | 7 | 8 | +22 |
|
20
|
18 | 38 | 2 | 12 | 24 | -45 |
Napoli and Pisa SC Last Matches
5/6 (83%)
0/6 (0%)
1/6 (17%)
Average stats (Last 6 matchs)
18 Sept 2025 - Champions League
13 Sept 2025 - Serie A
30 Aug 2025 - Serie A
23 Aug 2025 - Serie A
14 Aug 2025 - Clubs Friendlies
10 Aug 2025 - Clubs Friendlies
4/6 (67%)
1/6 (17%)
1/6 (17%)
Average stats (Last 6 matchs)
30 Aug 2025 - Serie A
14 Aug 2025 - Clubs Friendlies
10 Aug 2025 - Clubs Friendlies
9 Aug 2025 - Clubs Friendlies
4 Aug 2025 - Clubs Friendlies
3 Aug 2025 - Clubs Friendlies
4/6 (67%)
1/6 (17%)
1/6 (17%)
Average stats (Last 6 matchs)
18 Sept 2025 - Champions League
13 Sept 2025 - Serie A
23 Aug 2025 - Serie A
18 May 2025 - Serie A
3 May 2025 - Serie A
19 Apr 2025 - Serie A
0/6 (0%)
3/6 (50%)
3/6 (50%)
Average stats (Last 6 matchs)
14 Sept 2025 - Serie A
30 Aug 2025 - Serie A
24 Aug 2025 - Serie A
17 Aug 2025 - Coppa Italia
8 Aug 2025 - Clubs Friendlies
5 Aug 2025 - Clubs Friendlies
3/6 (50%)
1/6 (17%)
2/6 (33%)
Average stats (Last 6 matchs)
14 Sept 2025 - Serie A
30 Aug 2025 - Serie A
27 Jul 2025 - Clubs Friendlies
23 Jul 2025 - Clubs Friendlies
13 May 2025 - Serie B
9 May 2025 - Serie B
1/6 (17%)
3/6 (50%)
2/6 (33%)
Average stats (Last 6 matchs)
24 Aug 2025 - Serie A
17 Aug 2025 - Coppa Italia
8 Aug 2025 - Clubs Friendlies
5 Aug 2025 - Clubs Friendlies
30 Jul 2025 - Clubs Friendlies
4 May 2025 - Serie B
Napoli against Pisa SC Lineups: Starting 11
Formation : 4 - 1 - 4 - 1
Formation : 3 - 5 - 2
Substitutes
M. Ferrante
V. Milinkovic-Savic
DefenderM. Olivera
M. Gutierrez
A. Rrahmani
J. Jesus
L. Marianucci
MidfielderA. Vergara
F. Anguissa
S. Lobotka
G. Ambrosino
D. Neres
N. Lang
L. Lucca
S. Scuffet
Nicolas
DefenderR. Albiol
T. Esteves
S. Angori
A. Calabresi
J. Cuadrado
M. Tramoni
M. Hojholt
I. Vural
ForwardG. Piccinini
H. Meister
Lorran
Missing players
N. Contini
ForwardR. Lukaku
F. Coppola
Most goals and assists
Napoli
Pisa SC
R. Hojlund
(12 Goals)
S. Moreo
(7 Goals)
Giovane
(6 Assists)
M. Leris
(3 Assists)
, 
M. Tramoni
(3 Assists)
Napoli - Pisa SC Key Points
- Napoli won their last four Serie A matches, three witnessing under 2.5 goals.
- At home, Napoli won six of their last seven league matches, four coming by a clean sheet.
- Seven of Napoli’s last nine Serie A games produced two or fewer goals.
- Three of Napoli’s four competitive matches this season saw fewer than three goals.
- Pisa conceded exactly one goal in each of their three league games this season.
- Pisa failed to score in their last two Serie A matches.
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Our Napoli vs Pisa SC Prediction
Pisa haven’t excited their fans this season yet, scoring only one league goal. They have managed to keep it tight defensively, though, conceding exactly once in each of their three games. Napoli won’t mind keeping the goals to a minimum as they chase another win with a clean sheet. That has been the case in seven of their last eight Serie A wins, with the lone exception coming last weekend.
This match could keep the goals to a minimum, and our Napoli vs Pisa SC prediction is Napoli win and under 2.5.
Last Minute: Pre-match odds analysis Napoli Pisa SC
| Napoli vs Pisa SC | Opening odds | Pre-match odds | Odds Movements |
|---|---|---|---|
| Napoli wins | 1.2 | 1.35 | +12.5% |
| Draw | 6 | 5.6 | -6.7% |
| Pisa SC wins | 12 | 13 | +8.3% |
After kick-off, the latest odds movements show that:
- Napoli is most likely to win
- The odds for this bet have increased by 12.5% since opening
- The probability of this result was 83.3% and is now 74.1% (-9.3%)
Get up to €100 to bet on the Napoli vs. Pisa SC game
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.
