Italy - Serie A
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by Kennedy Kechula | in Serie A Predictions
Napoli haven't had the best news coming through after the confirmation of Romelu Lukaku’s injury. While the Belgian goes down with a thigh injury, the Italian champions start their title defence with an away match against Sassuolo. Read on for our preview and prediction.
On their return to Serie A, Sassuolo would have wanted an easier welcome but they don’t get to choose. At least they will be at home, where they did superbly in Serie B last season, winning 44 points from a possible 57.
The hosts have bolstered defensively and in this, and such matches, they will need the defenders to earn their pay. A concern though, is that in their last five season openers, Sassuolo won once and lost four.
Napoli have seven wins in the last eight opening day fixtures. The one they didn’t win happened to be last season and they’ll hope for an improvement. They start their charge for a fourth league title, hoping they can conjure up another good season on the road.
In their run up to winning the championship last season, Napoli lost only two of their 19 away matches, claiming 37 points on the road.
With their solidity in defence, Napoli having managed 19 clean sheets last season, the focus this transfer has been on attacking players. They come here having lost just twice in 20 matches against Sassuolo.
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The Best Betting Odds for Sassuolo v Napoli Match
Bookmaker | 1 | X | 2 | Bonus up to |
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6 | 4 | 1.57 |
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6.5 | 4 | 1.53 |
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6 | 3.8 | 1.55 |
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5.75 | 4 | 1.57 |
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6.1 | 4.1 | 1.52 |
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What is the prediction for the football match between Sassuolo and Napoli?
Our prediction for the Sassuolo vs Napoli match is: Napoli wins the match.
Probabilities according to our algorithm* of possible 1X2 football predictions and best odds for the match on 23/08/2025 between Sassuolo and Napoli in Serie A :
- The Sportytrader ⭐ algorithm estimates a probability of 27.97% for a win of Sassuolo against Napoli with odds of 6.5 at Betfred.
- The probability according to Sportytrader ⭐ for a draw between Sassuolo vs Napoli is 24.66% with odds of 4.22 at Melbet.
- Our prediction model gives a 47.37% chance ⭐ for a win of Napoli vs Sassuolo with odds of 1.62 at 22bet.
Sassuolo vs Napoli Form
Sassuolo and Napoli Last Matches

3/6 (50%)
2/6 (33%)
1/6 (17%)
Average stats (Last 6 matchs)
15 Aug 2025 - Coppa Italia
9 Aug 2025 - Clubs Friendlies
5 Aug 2025 - Clubs Friendlies
23 Jul 2025 - Clubs Friendlies
15 Jul 2025 - Clubs Friendlies
13 May 2025 - Serie B
4/6 (67%)
0/6 (0%)
2/6 (33%)
Average stats (Last 6 matchs)
15 Aug 2025 - Coppa Italia
23 Jul 2025 - Clubs Friendlies
15 Jul 2025 - Clubs Friendlies
13 May 2025 - Serie B
9 May 2025 - Serie B
1 May 2025 - Serie B
2/6 (33%)
3/6 (50%)
1/6 (17%)
Average stats (Last 6 matchs)
9 Aug 2025 - Clubs Friendlies
5 Aug 2025 - Clubs Friendlies
4 May 2025 - Serie B
25 Apr 2025 - Serie B
12 Apr 2025 - Serie B
6 Apr 2025 - Serie B

4/6 (67%)
1/6 (17%)
1/6 (17%)
Average stats (Last 6 matchs)
14 Aug 2025 - Clubs Friendlies
10 Aug 2025 - Clubs Friendlies
9 Aug 2025 - Clubs Friendlies
4 Aug 2025 - Clubs Friendlies
3 Aug 2025 - Clubs Friendlies
26 Jul 2025 - Clubs Friendlies
4/6 (67%)
1/6 (17%)
1/6 (17%)
Average stats (Last 6 matchs)
14 Aug 2025 - Clubs Friendlies
10 Aug 2025 - Clubs Friendlies
9 Aug 2025 - Clubs Friendlies
4 Aug 2025 - Clubs Friendlies
3 Aug 2025 - Clubs Friendlies
26 Jul 2025 - Clubs Friendlies
2/6 (33%)
3/6 (50%)
1/6 (17%)
Average stats (Last 6 matchs)
18 May 2025 - Serie A
3 May 2025 - Serie A
19 Apr 2025 - Serie A
7 Apr 2025 - Serie A
16 Mar 2025 - Serie A
23 Feb 2025 - Serie A
Sassuolo vs Napoli Stats: Head to Head (H2H)
0 %
17 %
83 %
Average stats (last H2H results)
28 Feb 2024 - Serie A
27 Aug 2023 - Serie A
17 Feb 2023 - Serie A
29 Oct 2022 - Serie A
30 Apr 2022 - Serie A
1 Dec 2021 - Serie A
Missing players

Y. Paz Blandon

M. Gutierrez
ForwardR. Lukaku
Sassuolo - Napoli Key Points
- Napoli won each of their last five league matches against Sassuolo.
- Napoli have 13 wins in their last 20 matches against Sassuolo.
- In the last eight meetings with Napoli, Sassuolo have one win.
- Sassuolo lost their last two league matches.
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Our Sassuolo vs Napoli Prediction
Sassuolo will head into this match as outright underdogs, and it will be a massive shock if they avoid defeat. This will be a tough reintroduction to the league for them. They face the champions, who unlike last season, are enjoying much calmer periods ahead of the league kickoff.
Last year at such a time the club was in shambles as Antonio Conte struggled with incoming and outbound transfers. Things are better now and, in their shape, they should be going for a win. Our prediction for Sassuolo v Napoli is that Napoli wins the match.
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

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