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Benfica Lisbon vs Bayer Leverkusen Prediction & Betting Tips - Champions League

Europe - Champions League

Benfica Lisbon
05/11/2025 15:00
Bayer Leverkusen

Prediction :

 

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 by Steve Ashfield | in Champions League Predictions

Both of these clubs are still searching for their first win in the league phase. Benfica are 35th in the table and are home on Wednesday to Bayer Leverkusen who are five places above them. Here's our match prediction.

Benfica aren't just hoping to get their first win to boost their Champions League qualification hopes. The Portuguese club have lost each of their first three games so far. Jose Mourinho hasn't quite been 'the special one' for them since he took over as coach. They are going well in the Primeira League and are yet to taste defeat but it's been a totally different story for them so far in Europe. Will it change on Wednesday?

Bayer Leverkusen have at least drawn two of their opening three games. They are only a point behind the play-off positions but are probably still having nightmares after their recent 7-2 home thrashing by defending champions PSG.

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The Best Betting Odds for Benfica Lisbon v Bayer Leverkusen Match

Bookmaker 1 X 2 Bonus up to
Bet365
1.91 3.6 3.9
Betfred
1.91 3.75 4
William Hill
1.91 3.7 3.7
Betway
1.95 3.6 3.75
Unibet
1.89 3.65 4
Check all Benfica Lisbon vs Bayer Leverkusen odds

What is the prediction for the football match between Benfica Lisbon and Bayer Leverkusen?

Our prediction for the Benfica Lisbon vs Bayer Leverkusen match is: both teams to score.

Probabilities according to our algorithm* of possible 1X2 football predictions and best odds for the match on 05/11/2025 between Benfica Lisbon and Bayer Leverkusen in Champions League :

  • The Sportytrader ⭐ algorithm estimates a probability of 38.56% for a win of Benfica Lisbon against Bayer Leverkusen with odds of 1.95 at Betway.
  • The probability according to Sportytrader ⭐ for a draw between Benfica Lisbon vs Bayer Leverkusen is 28.09% with odds of 3.84 at LSbet.
  • Our prediction model gives a 33.35% chance ⭐ for a win of Bayer Leverkusen vs Benfica Lisbon with odds of 4 at Betfred.

Benfica Lisbon - Bayer Leverkusen Prediction and Best Odds:

Benfica Lisbon Bayer Leverkusen Prediction Probability Odds
Benfica Lisbon wins 38.56% 1.95 at Betway
Over 2.5 goals 73.29% 1.85 at Bet365
Both Team To Score 66.67% 1.61 at Ladbrokes
Half-time / Full-time : Benfica Lisbon/Benfica Lisbon 17.61% 3 at Bet365

Benfica Lisbon vs Bayer Leverkusen Form

Benfica Lisbon and Bayer Leverkusen's standings in the Champions League

Teams Pts P W D L GD
21
Bayer Leverkusen
Bayer Leverkusen
5 4 1 2 1 -4
35
Benfica Lisbon
Benfica Lisbon
0 4 0 0 4 -6

Benfica Lisbon and Bayer Leverkusen Last Matches

Benfica Lisbon
Benfica Lisbon Last matches
D W L W W W
Wins

4/6 (67%)

Draw

1/6 (17%)

Losses

1/6 (17%)

Average stats (Last 6 matchs)

2.67 Total goals
0% BTTS
2.17 Goals scored
0.5 Goals conceded
67% Over 2.5
33% Under 2.5

1 Nov 2025 - Liga Portugal

Vitoria SC Guimaraes
0 :  3
Benfica Lisbon

29 Oct 2025 - Portugal League Cup

Benfica Lisbon
3 :  0
Tondela

25 Oct 2025 - Liga Portugal

Benfica Lisbon
5 :  0
Arouca

21 Oct 2025 - Champions League

Newcastle
3 :  0
Benfica Lisbon

17 Oct 2025 - Taca de Portugal

Chaves
0 :  2
Benfica Lisbon

5 Oct 2025 - Liga Portugal

Porto
0 :  0
Benfica Lisbon
D L D W W W
Wins

3/6 (50%)

Draw

2/6 (33%)

Losses

1/6 (17%)

Average stats (Last 6 matchs)

3.33 Total goals
67% BTTS
2.33 Goals scored
1 Goals conceded
67% Over 2.5
33% Under 2.5

29 Oct 2025 - Portugal League Cup

Benfica Lisbon
3 :  0
Tondela

25 Oct 2025 - Liga Portugal

Benfica Lisbon
5 :  0
Arouca

26 Sept 2025 - Liga Portugal

Benfica Lisbon
2 :  1
Gil Vicente

23 Sept 2025 - Liga Portugal

Benfica Lisbon
1 :  1
Rio Ave

16 Sept 2025 - Champions League

Benfica Lisbon
2 :  3
Qarabag FK

12 Sept 2025 - Liga Portugal

Benfica Lisbon
1 :  1
Santa Clara
W L D W L W
Wins

3/6 (50%)

Draw

1/6 (17%)

Losses

2/6 (33%)

Average stats (Last 6 matchs)

2 Total goals
0% BTTS
1.33 Goals scored
0.67 Goals conceded
50% Over 2.5
50% Under 2.5

1 Nov 2025 - Liga Portugal

Vitoria SC Guimaraes
0 :  3
Benfica Lisbon

21 Oct 2025 - Champions League

Newcastle
3 :  0
Benfica Lisbon

17 Oct 2025 - Taca de Portugal

Chaves
0 :  2
Benfica Lisbon

5 Oct 2025 - Liga Portugal

Porto
0 :  0
Benfica Lisbon

30 Sept 2025 - Champions League

Chelsea
1 :  0
Benfica Lisbon

20 Sept 2025 - Liga Portugal

AVS Futebol SAD
0 :  3
Benfica Lisbon
Bayer Leverkusen
Bayer Leverkusen Last matches
W W L W W L
Wins

4/6 (67%)

Draw

0/6 (0%)

Losses

2/6 (33%)

Average stats (Last 6 matchs)

4.83 Total goals
50% BTTS
2.33 Goals scored
2.5 Goals conceded
67% Over 2.5
33% Under 2.5

1 Nov 2025 - Bundesliga

Bayern Munich
3 :  0
Bayer Leverkusen

29 Oct 2025 - DFB Pokal

Paderborn
2 :  4
Bayer Leverkusen

26 Oct 2025 - Bundesliga

Bayer Leverkusen
2 :  0
Freiburg

21 Oct 2025 - Champions League

Bayer Leverkusen
2 :  7
PSG

18 Oct 2025 - Bundesliga

1 Fsv Mainz 05
3 :  4
Bayer Leverkusen

4 Oct 2025 - Bundesliga

Bayer Leverkusen
2 :  0
Union Berlin
W D D W L W
Wins

3/6 (50%)

Draw

2/6 (33%)

Losses

1/6 (17%)

Average stats (Last 6 matchs)

3.5 Total goals
67% BTTS
1.83 Goals scored
1.67 Goals conceded
33% Over 2.5
67% Under 2.5

26 Oct 2025 - Bundesliga

Bayer Leverkusen
2 :  0
Freiburg

21 Oct 2025 - Champions League

Bayer Leverkusen
2 :  7
PSG

4 Oct 2025 - Bundesliga

Bayer Leverkusen
2 :  0
Union Berlin

1 Oct 2025 - Champions League

Bayer Leverkusen
1 :  1
PSV Eindhoven

21 Sept 2025 - Bundesliga

Bayer Leverkusen
1 :  1
Mönchengladbach

12 Sept 2025 - Bundesliga

Bayer Leverkusen
3 :  1
Eintracht Frankfurt
D D W W W L
Wins

3/6 (50%)

Draw

2/6 (33%)

Losses

1/6 (17%)

Average stats (Last 6 matchs)

4.83 Total goals
83% BTTS
2.5 Goals scored
2.33 Goals conceded
100% Over 2.5
0% Under 2.5

1 Nov 2025 - Bundesliga

Bayern Munich
3 :  0
Bayer Leverkusen

29 Oct 2025 - DFB Pokal

Paderborn
2 :  4
Bayer Leverkusen

18 Oct 2025 - Bundesliga

1 Fsv Mainz 05
3 :  4
Bayer Leverkusen

27 Sept 2025 - Bundesliga

St. Pauli
1 :  2
Bayer Leverkusen

18 Sept 2025 - Champions League

FC Copenhagen
2 :  2
Bayer Leverkusen

30 Aug 2025 - Bundesliga

Werder Bremen
3 :  3
Bayer Leverkusen
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Benfica Lisbon - Bayer Leverkusen: Form Analysis

Benfica only have Ajax below them in the league phase. Three games have been lost so far with just two goals scored and seven conceded. They are only three points behind the final play-off position and after this match, Benfica are away to bottom-of-the-table Ajax.

Mourinho magic needed by Benfica.

Jose Mourinho will be out to work some magic then and get his new club climbing up the table. Benfica began the league phase with a disappointing 3-2 loss at home to Qarabag. More than disappointing really as they led 2-0 after 16 minutes.

Their next two games were both played in England. There was no happy return for Mourinho as a 1-0 loss at Chelsea was followed by a 3-0 loss at Newcastle United. Domestic form is better though with seven wins and three draws in ten games taking them to third in the table.

Bayer Leverkusen have two points from their three games. The German Bundesliga side twice came from behind to draw their opening game 2-2 at FC Copenhagen, needing a 91st minute own goal to secure a point.

A lead at home to PSV was lost as they drew 1-1. Then came the humiliating 7-2 home loss to PSG. A good result in Portugal is needed as their next game sees them travel to Manchester City. Leverkusen are fifth in the German Bundesliga but lost 3-0 at Bayern Munich at the weekend.

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Benfica Lisbon against Bayer Leverkusen Lineups: Starting 11

Benfica Lisbon

Formation : 4 - 2 - 3 - 1

1
A. Trubin
8
F. Aursnes
44
T. Araujo
30
N. Otamendi
26
S. Dahl
20
R. Rios
5
E. Barrenechea
11
D. Lukebakio
18
L. Barreiro
10
G. Sudakov
14
V. Pavlidis
35
C. Kofane
19
E. Poku
9
C. Echeverri
20
A. Grimaldo
30
I. Maza
24
A. Garcia
13
Arthur
12
E. Tapsoba
5
L. Bade
4
J. Quansah
1
M. Flekken

Formation : 3 - 4 - 2 - 1

Bayer Leverkusen

Benfica Lisbon & Bayer Leverkusen Squad Analysis

Benfica are only three points behind the play-offs but they can't afford to let that gap get any wider. Three successive defeats are making them rue  giving away a 2-0 lead at home to Qarabag and losing the match.

They have injury problems for this home game against Bayer Leverkusen. Bah, Bruma and Silva will all be missing on Wednesday. Twice they have conceded three goals in this league phase and will have Fredrik Aursnes at left-back, not his usual role.

Pavlidis needs to reproduce his domestic form in Europe.

Up front they will be hoping for some goals from Vangelis Pavlidis. He's already scored 13 goals this season but hasn't quite made an impact in this competition with just a single goal to his name so far.

Bayer Leverkusen also have several selection problems ahead of this trip to Benfica. They have two points so far but really need to get that elusive first victory. Their captain Robert Andrich definitely misses this game after being sent off against PSG.

He's one of several players who are not able to be selected for this fixture. One bit of good news though is that attacker Patrik Schick may make his return after being out for the past few months.

Most goals and assists

CD Huachipato Benfica Lisbon
CD Huachipato Bayer Leverkusen
Top Goalscorer
Greece V. Pavlidis (10 Goals)
Top Goalscorer
Spain A. Grimaldo (7 Goals)
Best assists
Belgium D. Lukebakio (3 Assists)
Best assists
Netherlands E. Poku (3 Assists)
Spain A. Grimaldo (3 Assists)

Benfica Lisbon - Bayer Leverkusen Key Points

  1. Both teams have scored in each of Leverkusen's three games in this league phase.
  2. Three of Benfica's last four home league fixtures have seen both teams get on the scoresheet.
  3. Both teams have scored in three of Leverkusen's last five away European fixtures.
  4. 10 of Leverkusen's last 13 games in all competitions have seen both teams score.
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Our Benfica Lisbon vs Bayer Leverkusen Prediction

Both clubs still have a chance of making it into the knockout stages of the Champions League. It's getting tough for Benfica though as they are yet to earn a point after the first three games of the league phase. Two of their three losses were on the road though.

Bayer Leverkusen have earned a couple of points so far and will find this assignment a bit easier than recent games against PSG and Bayern Munich in which ten goals were conceded. Our main Benfica v Bayer Leverkusen prediction is both teams to score.

Prediction :

 

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Benfica Lisbon vs Bayer Leverkusen - Other Interesting Predictions

Alejandro Grimaldo to score

Odds 5.5
Alejandro Grimaldo is Leverkusen's top scorer this season. He's already scored once for the Germans in the Champions League this term.
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Last Minute: Pre-match odds analysis Benfica Lisbon Bayer Leverkusen

Benfica Lisbon vs Bayer Leverkusen Opening odds Pre-match odds Odds Movements
Benfica Lisbon wins 2 1.91 -4.5%
Draw 3.75 3.6 -4.0%
Bayer Leverkusen wins 3.5 3.9 +11.4%
Latest odds movements:

After kick-off, the latest odds movements show that:

  • Benfica Lisbon is most likely to win
  • The odds for this bet have decreased by 4.5% since opening
  • The probability of this result was 50.0% and is now 52.4% (2.4%)

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Benfica Lisbon vs Bayer Leverkusen match : Frequently asked questions

Benfica will play Bayer Leverkusen on Wednesday November 5. This Champions League match is due to get underway at 20:00 UK time.

Bayer Leverkusen will be travelling to the Estado de Luiz in Lisbon, Portugal to take on Benfica. They are yet to win away in the league phase.

TNT Sports are broadcasting this game live in the UK. To keep in touch with all the action, visit our Champions League livescore to access updated statistics and live text commentary that will help your in-play bets or check how your pre-match wagers are faring.

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Benfica Lisbon vs Bayer Leverkusen Prediction

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