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Manchester City vs Napoli Prediction & Betting Tips - Champions League

Europe - Champions League

Manchester City
18/09/2025 15:00
Napoli

Prediction :

 

Over 2.5

 
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 by Kennedy Kechula | in Champions League Predictions

Under the Champions League lights, Manchester City return, looking to light up the big stage and reclaim the title they won two years ago. The English giants start off the campaign at home to Italian champions Napoli. This will mark a fifth meeting between the two, but the first one since 2017. Let’s dive in for our preview of the match and a prediction.

Manchester City won their last two meetings with Napoli, and they will be gunning for the same. However, the hosts have blown hot and cold this season, and this will not be an easy match to call for the Cityzens.

Another key stat for this game is that in seven meetings, Pep Guardiola has won three and lost four against Antonio Conte’s teams. The Italian manager will be managing a fifth different club in the Champions League, a marker of his experience. He will hope this know-how transforms Napoli’s fortunes in matches played on English soil. Napoli have never won away in England in European competitions.


 

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The Best Betting Odds for Manchester City v Napoli Match

Bookmaker 1 X 2 Bonus up to
Bet365
1.65 4 5
Betfred
1.67 4 5.5
William Hill
1.67 3.8 5
Betway
1.7 4 4.5
Unibet
1.61 4.1 5.2
Check all Manchester City vs Napoli odds
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What is the prediction for the football match between Manchester City and Napoli?

Our prediction for the Manchester City vs Napoli match is: over 2.5.

Probabilities according to our algorithm* of possible 1X2 football predictions and best odds for the match on 18/09/2025 between Manchester City and Napoli in Champions League :

  • The Sportytrader ⭐ algorithm estimates a probability of 45% for a win of Manchester City against Napoli with odds of 1.7 at Betway.
  • The probability according to Sportytrader ⭐ for a draw between Manchester City vs Napoli is 14.61% with odds of 4.25 at 22bet.
  • Our prediction model gives a 40.39% chance ⭐ for a win of Napoli vs Manchester City with odds of 5.5 at Betfred.

Manchester City vs Napoli Form

Manchester City and Napoli's standings in the Champions League

Teams Pts P W D L GD
8
Napoli
Napoli
0 0 0 0 0 0
8
Manchester City
Manchester City
0 0 0 0 0 0

Manchester City and Napoli Last Matches

Manchester City
Manchester City Last matches
L W W L L W
Wins

3/6 (50%)

Draw

0/6 (0%)

Losses

3/6 (50%)

Average stats (Last 6 matchs)

3.67 Total goals
33% BTTS
2.33 Goals scored
1.33 Goals conceded
83% Over 2.5
17% Under 2.5

14 Sep 2025 - Premier League

Manchester City
3 :  0
Manchester United

31 Aug 2025 - Premier League

Brighton
2 :  1
Manchester City

23 Aug 2025 - Premier League

Manchester City
0 :  2
Tottenham

16 Aug 2025 - Premier League

Wolves
0 :  4
Manchester City

9 Aug 2025 - Clubs Friendlies

Palermo
0 :  3
Manchester City

30 Jun 2025 - Club World Cup

Manchester City
3 :  4
Al Hilal
W W W L L W
Wins

4/6 (67%)

Draw

0/6 (0%)

Losses

2/6 (33%)

Average stats (Last 6 matchs)

4 Total goals
33% BTTS
2.83 Goals scored
1.17 Goals conceded
67% Over 2.5
33% Under 2.5

14 Sep 2025 - Premier League

Manchester City
3 :  0
Manchester United

23 Aug 2025 - Premier League

Manchester City
0 :  2
Tottenham

30 Jun 2025 - Club World Cup

Manchester City
3 :  4
Al Hilal

22 Jun 2025 - Club World Cup

Manchester City
6 :  0
Al Ain FC

18 Jun 2025 - Club World Cup

Manchester City
2 :  0
WAC Casablanca

20 May 2025 - Premier League

Manchester City
3 :  1
Bournemouth
L W W W W L
Wins

4/6 (67%)

Draw

0/6 (0%)

Losses

2/6 (33%)

Average stats (Last 6 matchs)

3.33 Total goals
33% BTTS
2.5 Goals scored
0.83 Goals conceded
67% Over 2.5
33% Under 2.5

31 Aug 2025 - Premier League

Brighton
2 :  1
Manchester City

16 Aug 2025 - Premier League

Wolves
0 :  4
Manchester City

9 Aug 2025 - Clubs Friendlies

Palermo
0 :  3
Manchester City

26 Jun 2025 - Club World Cup

Juventus
2 :  5
Manchester City

25 May 2025 - Premier League

Fulham
0 :  2
Manchester City

17 May 2025 - FA Cup

Crystal Palace
1 :  0
Manchester City
Napoli
Napoli Last matches
W W W W W W
Wins

6/6 (100%)

Draw

0/6 (0%)

Losses

0/6 (0%)

Average stats (Last 6 matchs)

3.17 Total goals
50% BTTS
2.5 Goals scored
0.67 Goals conceded
67% Over 2.5
33% Under 2.5

13 Sep 2025 - Serie A

Fiorentina
1 :  3
Napoli

30 Aug 2025 - Serie A

Napoli
1 :  0
Cagliari

23 Aug 2025 - Serie A

Sassuolo
0 :  2
Napoli

14 Aug 2025 - Clubs Friendlies

Napoli
2 :  1
Olympiacos

10 Aug 2025 - Clubs Friendlies

Napoli
4 :  0
ASD Sorrento 1945

9 Aug 2025 - Clubs Friendlies

Napoli
3 :  2
Girona
L D W W W W
Wins

4/6 (67%)

Draw

1/6 (17%)

Losses

1/6 (17%)

Average stats (Last 6 matchs)

3 Total goals
67% BTTS
2 Goals scored
1 Goals conceded
67% Over 2.5
33% Under 2.5

30 Aug 2025 - Serie A

Napoli
1 :  0
Cagliari

14 Aug 2025 - Clubs Friendlies

Napoli
2 :  1
Olympiacos

10 Aug 2025 - Clubs Friendlies

Napoli
4 :  0
ASD Sorrento 1945

9 Aug 2025 - Clubs Friendlies

Napoli
3 :  2
Girona

4 Aug 2025 - Clubs Friendlies

Napoli
1 :  1
Casertana

3 Aug 2025 - Clubs Friendlies

Napoli
1 :  2
Brest
D W W D W W
Wins

4/6 (67%)

Draw

2/6 (33%)

Losses

0/6 (0%)

Average stats (Last 6 matchs)

1.67 Total goals
33% BTTS
1.33 Goals scored
0.33 Goals conceded
17% Over 2.5
83% Under 2.5

13 Sep 2025 - Serie A

Fiorentina
1 :  3
Napoli

23 Aug 2025 - Serie A

Sassuolo
0 :  2
Napoli

18 May 2025 - Serie A

Parma
0 :  0
Napoli

3 May 2025 - Serie A

Lecce
0 :  1
Napoli

19 Apr 2025 - Serie A

Monza
0 :  1
Napoli

7 Apr 2025 - Serie A

Bologna
1 :  1
Napoli

Manchester City vs Napoli Stats: Head to Head (H2H)

Manchester City

100 %

Draw

0 %

Napoli

0 %

Average stats (last H2H results)

4.5
Total goals
100%
BTTS
3
Goals scored (home team)
1.5
Goals scored (away team)
100%
Over 2.5
0%
Under 2.5

1 Nov 2017 - Champions League

Napoli
2 :  4
Manchester City

17 Oct 2017 - Champions League

Manchester City
2 :  1
Napoli
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Manchester City - Napoli: Form Analysis

While Manchester City targets a second Champions League title, the fact remains they aren’t as good as when they won the first. This season, City have been on and off, with inconsistencies that started in 2024/25.

Pep Guardiola’s side beat Wolves 4-0 to start their campaign but slumped to defeats against Tottenham Hotspur and Brighton. They did recover in their most recent game, beating Manchester United 3-0.

By their standards, it has been a slow start to the season. Home fans will hope the start of the Champions League heralds the return to glory days. In the league phase last season, they finished 22nd before losing in the playoff round.

Napoli are marking a return to the Champions League after last season’s absence.

Napoli missed out on Champions League football last season and used the time to reshape and strategize. Their rebuild brought forth another league title, and they’ve followed it up with a solid start to 2025/26.

Three straight wins will embolden the Italians on this trip to Manchester. In their opening game, Napoli trounced Sassuolo 2-0 before beating Cagliari 1-0 and seeing off Fiorentina 3-1 most recently.

In their last season in the Champions League, Real Madrid reached the round of 16 after finishing second in their group.

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Manchester City vs Napoli last Lineups

Manchester City

Formation : 4 - 3 - 3

25
G. Donnarumma
33
N. O'Reilly
45
A. Khusanov
3
R. Dias
24
J. Gvardiol
20
B. Silva
16
Rodri
4
T. Reijnders
47
P. Foden
9
E. Haaland
11
J. Doku
19
R. Hojlund
8
S. Mctominay
99
F. Anguissa
11
K. De Bruyne
21
M. Politano
68
S. Lobotka
37
L. Spinazzola
4
A. Buongiorno
31
S. Beukema
22
G. Di Lorenzo
32
V. Milinkovic-Savic

Formation : 4 - 1 - 4 - 1

Napoli

Missing players

Manchester City
Manchester City
Defender

R. Ait-Nouri

J. Stones

Midfielder

M. Kovacic

R. Cherki

Forward

O. Marmoush

Napoli
Napoli
Goalkeeper

N. Contini

Defender

A. Rrahmani

Forward

R. Lukaku

Manchester City & Napoli Squad Analysis

Manchester City’s talisman Erling Haaland will be targeting his 50th Champions League goal here. The Norwegian had a perfect warm-up for this game with two goals in the Manchester derby.

He is now just two goals away from becoming the ninth-highest scorer in this competition. This early in the season, the City forward is already averaging an xG of 5.74.

City will also hope Phil Foden’s goal in the Manchester derby marks his return to form after struggling a bit earlier. The hosts will be without forwards Omar Marmoush and Rayan Cherki, who are out injured.

Romelu Lukaku will sit out of this match as he recovers from a thigh injury.

There will be a number of reunions at the Etihad Stadium when these two sides face off. Kevin De Bruyne’s will be the big one. The Belgian enjoyed a lot of success at Manchester City before leaving for Napoli last summer.

He arrives for this game in the best shape, having scored in Napoli’s 3-1 win over Fiorentina. That was his season goal for Napoli, and he brings forth an xG of 1.24 this early in the season.

Another scorer in that game was Rasmus Hojlund, who will be returning to town, having left Manchester United in the summer, while Scott McTominay, a former Manchester United midfielder, is also in the mix.

Most goals and assists

CD Huachipato Manchester City
CD Huachipato Napoli
Top Goalscorer
Norway E. Haaland (5 Goals)
Top Goalscorer
Belgium K. De Bruyne (2 Goals)
Best assists
Belgium J. Doku (2 Assists)
Best assists
Italy M. Politano (1 Assists)
Italy A. Buongiorno (1 Assists)
Italy L. Spinazzola (1 Assists)
Cameroon F. Anguissa (1 Assists)

Manchester City - Napoli Key Points

  1. Manchester City’s last four Champions League matches had over 2.5 goals.
  2. 21 goals were scored in Manchester City’s last five Champions League games.
  3. Four of Napoli’s last eight Champions League matches produced over 2.5 goals.
  4. Each of these teams’ last three meetings produced over 2.5 goals.
  5. Manchester City scored 3+ in three of their last four home Champions League matches.
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Our Manchester City vs Napoli Prediction

Napoli are in fine form so far and will be hoping their perfect start to the season doesn’t end here. In their first visit to City in 2011, the match ended in a 1-1 draw, and that is the only one of their meetings to have had under 2.5 goals.

Three or more goals were scored in each of the other three. Both teams are coming off comfortable wins, having scored three each, and we could have another high-scoring game here. Our prediction for Manchester City v Napoli is for over 2.5.

Prediction :

 

Over 2.5

 
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Manchester City vs Napoli - Other Interesting Predictions

Game to end in a draw

Odds 4

Manchester City have had a tough start to the season, and they will not have it any easier against the Italian champions. However, the visitors come here on a poor run away to English teams. On the other hand, Pep Guardiola doesn’t have a great record against Antonio Conte. All these don’t point to a single team with an advantage over the other. As such, we will back this game to end in a draw.

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Manchester City vs Napoli match : Frequently asked questions

The Manchester City v Napoli match will be played at Etihad Stadium in Manchester.

The Manchester City v Napoli match will be aired on TNT Sports for the UK fans, while in Italy it will be aired on Sky, with highlights on Amazon Prime. On SportyTrader, we will have the live updates through the UEFA Champions League page.

The Manchester City v Napoli match will be played on Thursday, 18th September.

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Manchester City vs Napoli Prediction
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