Bayer Leverkusen vs Villarreal Prediction & Betting Tips - Champions League
Europe - Champions League
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by Ita Emmanuel | in Champions League Predictions
20th-placed Bayer Leverkusen will look to seal their spot in the playoff places as they welcome 35th-placed Villarreal to Bay Arena in the 2025–26 Champions League league-phase final round of matches on Wednesday. Can Die Werkself defeat Villarreal to qualify for the knockout play-offs? Here is our prediction.
Last week’s defeat to Olympiakos Piraeus dealt a final blow to Bayer Leverkusen’s hopes of automatic qualification to the 2025-26 Champions League round of 16. The 2023–24 Bundesliga champions are still in contention for a place in the knockout play-offs despite that setback. However, with just a one-point cushion above the elimination zone, they must avoid defeat to stand a chance of advancing to the next round.
Villarreal are among the whipping boys in this year's Champions League. They head into this final round matches already eliminated, having lost six of their seven matches, drawing one and winning none. The Yellow Submarines are winless in their last five away matches against German sides in European club competitions, drawing three and losing two. Can they break this jinx with an unlikely victory against Leverkusen and exit the competition on a high note? Stay tuned as we dive into detailed stats, team news, and more!
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Bayer Leverkusen v Villarreal Best Betting Odds
| Bookmaker | 1 | X | 2 | Bonus up to |
|---|---|---|---|---|
|
1.72 | 4.2 | 4.6 |
|
|
1.67 | 4.1 | 4.76 |
|
|
1.68 | 4.14 | 4.64 |
|
|
1.67 | 4.1 | 4.75 |
|
|
1.66 | 4.1 | 4.8 |
|
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What is the prediction for the football match between Bayer Leverkusen and Villarreal?
Our prediction for the Bayer Leverkusen vs Villarreal match is: Bayer Leverkusen wins.
Probabilities according to our algorithm* of possible 1X2 football predictions and best odds for the match on 28/01/2026 between Bayer Leverkusen and Villarreal in Champions League :
- The Sportytrader ⭐ algorithm estimates a probability of 52.04% for a win of Bayer Leverkusen against Villarreal with odds of 1.74 at 888Starz.
- The probability according to Sportytrader ⭐ for a draw between Bayer Leverkusen vs Villarreal is 16.34% with odds of 4.31 at 888Starz.
- Our prediction model gives a 31.61% chance ⭐ for a win of Villarreal vs Bayer Leverkusen with odds of 5.2 at Tonybet.
Bayer Leverkusen - Villarreal Prediction and Best Odds:
| Bayer Leverkusen Villarreal Prediction | Probability | Odds |
|---|---|---|
| Bayer Leverkusen wins | 52.04% | 1.74 at 888Starz |
| Over 2.5 goals | 63.51% | 1.78 at Bet365 |
| Both Team To Score | 57.14% | |
| Half-time / Full-time : Bayer Leverkusen/Bayer Leverkusen | 20.45% | 2.5 at Bet365 |
Bayer Leverkusen vs Villarreal Form
Bayer Leverkusen and Villarreal's standings in the Champions League
| Teams | Pts | P | W | D | L | GD |
|---|---|---|---|---|---|---|
|
16
|
12 | 8 | 3 | 3 | 2 | -1 |
|
35
|
1 | 8 | 0 | 1 | 7 | -13 |
Bayer Leverkusen and Villarreal Last Matches
3/6 (50%)
0/6 (0%)
3/6 (50%)
Average stats (Last 6 matchs)
24 Jan 2026 - Bundesliga
20 Jan 2026 - Champions League
17 Jan 2026 - Bundesliga
10 Jan 2026 - Bundesliga
20 Dec 2025 - Bundesliga
13 Dec 2025 - Bundesliga
3/6 (50%)
1/6 (17%)
2/6 (33%)
Average stats (Last 6 matchs)
24 Jan 2026 - Bundesliga
10 Jan 2026 - Bundesliga
13 Dec 2025 - Bundesliga
10 Dec 2025 - Champions League
29 Nov 2025 - Bundesliga
8 Nov 2025 - Bundesliga
3/6 (50%)
0/6 (0%)
3/6 (50%)
Average stats (Last 6 matchs)
20 Jan 2026 - Champions League
17 Jan 2026 - Bundesliga
20 Dec 2025 - Bundesliga
6 Dec 2025 - Bundesliga
2 Dec 2025 - DFB Pokal
25 Nov 2025 - Champions League
2/6 (33%)
0/6 (0%)
4/6 (67%)
Average stats (Last 6 matchs)
24 Jan 2026 - LaLiga
20 Jan 2026 - Champions League
17 Jan 2026 - LaLiga
10 Jan 2026 - LaLiga
3 Jan 2026 - LaLiga
21 Dec 2025 - LaLiga
2/6 (33%)
0/6 (0%)
4/6 (67%)
Average stats (Last 6 matchs)
24 Jan 2026 - LaLiga
20 Jan 2026 - Champions League
10 Jan 2026 - LaLiga
21 Dec 2025 - LaLiga
10 Dec 2025 - Champions League
6 Dec 2025 - LaLiga
2/6 (33%)
1/6 (17%)
3/6 (50%)
Average stats (Last 6 matchs)
17 Jan 2026 - LaLiga
3 Jan 2026 - LaLiga
17 Dec 2025 - Copa del Rey
3 Dec 2025 - Copa del Rey
30 Nov 2025 - LaLiga
25 Nov 2025 - Champions League
Bayer Leverkusen - Villarreal: Form Analysis
Iranian forward Mehdi Taremi and Portugal defender Costinha’s first-half goals were enough to condemn Bayer Leverkusen to their second Champions League defeat this season, effectively quashing their hopes of a top-eight finish. That result also saw Kasper Hjulmand’s side suffered defeats in three consecutive matches for the first time this season.
However, the Black and Reds will be confident of a positive result on Wednesday. They defeated Werder Bremen 1–0 over the weekend in the Bundesliga to return to winning ways and have avoided defeat in three of their last four home matches across competitions.
Villarreal are among the bottom three teams in the Champions League league-phase standings this season with zero wins in seven matches
Villarreal’s poor run in the Champions League continued in their last outing against an equally underperforming Dutch side Ajax. They surrendered a one-goal lead, and eventually fell to a shock 2–1 home defeat to the visitors, courtesy of Oliver Edvardsen’s stoppage-time winner.
El Submarino Amarillo come into this match on the back of a 2–0 home defeat to Real Madrid in La Liga on Saturday. That result extended their losing streak to three matches in all competitions, including last week's UCL loss to Ajax.
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Bayer Leverkusen against Villarreal Lineups: Starting 11
Formation : 3 - 4 - 3
Formation : 4 - 4 - 2
Substitutes
N. Lomb
J. Omlin
DefenderE. Tapsoba
Arthur
A. Tape
E. Palacios
C. Kofane
M. Culbreath
E. Poku
L. Junior
D. Conde
DefenderD. Budesca
P. Gueye
H. Lopez
D. Parejo
G. Mikautadze
A. Moleiro
A. Pedraza
G. Moreno
Missing players
M. Flekken
ForwardN. Tella
E. Ben Seghir
L. Costa
W. Kambwala
ForwardP. Cabanes
Bayer Leverkusen & Villarreal Squad Analysis
Janis Blaswich is expected to return in goal for Bayer Leverkusen as competitor Mark Flekken continues nursing a knee injury. The hosts will miss their defensive cornerstone Edmond Tapsoba, who is down with a muscle injury, with Jarell Quansah expected to fill the gap.
Jonas Hofmann will return on the right wing to provide width and momentum to the team’s attack, making light of Nathan Tella’s absence. Álex Grimaldo boasts a team-high 10 goals across all competitions for the German side this season and is available to return in the attack alongside nine-goal Patrik Schick.
Bayer Leverkusen have conceded two goals per contest across their seven Champions League league-phase matches this season
Villarreal’s momentum on the left flank is likely to be tempered significantly due to the absence of top-rated left-back Willy Kambwala. They have also been dealt a further blow in the defense with Pau Cabanes sidelined alongside Juan Foyth, with the absence of this pair likely to weigh heavily on their overall composure at the back.
Meanwhile, AFCON-winning midfield sensation, Pape Gueye, is back and available to return to the middle of the pack alongside Pablo Moleiro and Daniel Parejo Muñoz, while Tani Oluwaseyi and Gerard Moreno pilot the attack.
Most goals and assists
Bayer Leverkusen
Villarreal
A. Grimaldo
(4 Goals)
, 
P. Schick
(4 Goals)
T. Oluwaseyi
(2 Goals)
A. Grimaldo
(3 Assists)
I. Akhomach
(2 Assists)
Bayer Leverkusen - Villarreal Key Points
- Bayer Leverkusen have avoided defeat in three of their last four matches across all competitions.
- Villarreal are winless in their seven Champions League league-phase matches this season.
- Villarreal have lost their last three matches in all competitions.
- Villarreal have lost two of their last three away matches.
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Our Bayer Leverkusen vs Villarreal Prediction
Villarreal stand little chance heading into Wednesday's contest. They have gone winless in their seven Champions League league-phase matches this season, lost their last three matches, including two of their last three away fixtures.
Meanwhile, Bayer Leverkusen have fared relatively better, avoiding defeat in three of their last four home fixtures. Unlike their visiting Spanish opponents, Villarreal, Die Werkself are strongly in the race to finish in the playoff places and will count on the support of the home fans to ace this must-win clash. Our Bayer Leverkusen vs Villarreal prediction is Bayer Leverkusen wins.
Bayer Leverkusen vs Villarreal Alternative Predictions
Over 2.5 goals
Last Minute: Pre-match odds analysis Bayer Leverkusen Villarreal
| Bayer Leverkusen vs Villarreal | Opening odds | Pre-match odds | Odds Movements |
|---|---|---|---|
| Bayer Leverkusen wins | 1.96 | 1.74 | -11.2% |
| Draw | 3.92 | 4.31 | +9.9% |
| Villarreal wins | 4.02 | 5.2 | +29.4% |
After kick-off, the latest odds movements show that:
- Bayer Leverkusen is most likely to win
- The odds for this bet have decreased by 11.2% since opening
- The probability of this result was 51.0% and is now 57.5% (6.5%)
All tips are fully researched and given in good faith, but profits cannot be guaranteed.
