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by Kennedy Kechula | in ATP US Open Predictions
Top seed Jannik Sinner will face 10th seed Lorenzo Musetti next in his US Open title defence. Their third career meeting and the first at a major will take place at the quarter-finals. Read on to find our prediction for this match.
Jannik Sinner has been in splendid form in New York, winning four matches with only one set lost. The Italian, who is currently on an 11-match winning streak in this major, defeated Alexander Bublik in the last round.
Sinner dominated the in-form Bublik, snapping the Kazakh’s 11-match winning streak by the loss of just three games. Currently in second place in the live ranking, Sinner has compiled an incredible 35-4 and won two Grand Slam titles.
Lorenzo Musetti has never won against Sinner, losing both previous duels against his countryman without winning a set. Their most recent showdown was two years ago on clay in Monte Carlo.
He faces a daunting task given Sinner’s rich vein of form. Musetti, who also has lost just one set in his run to the last eight, is coming off a dominant display against Jaume Munar.
The Italian, who hasn’t lost more than six games in his last three fixtures, defeated Munar by the loss of four games. Now with 30 wins in 42 outings this year, the 23-year-old has moved up to ninth in the live ranking.
Musetti is seeking to make the semi-finals of a major for the second time this year.
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The Best Betting Odds for Jannik Sinner v Lorenzo Musetti Match
Bookmaker | 1 | 2 | Bonus up to |
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1.05 | 11 |
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1.06 | 9 |
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1.03 | 12 |
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1.06 | 9 |
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1.07 | 10 |
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Who will win the Jannik Sinner vs Lorenzo Musetti Tennis game?
Our prediction for the Jannik Sinner vs Lorenzo Musetti match is: Sinner to win in straight sets.
The best winner predictions and betting odds for the Jannik Sinner vs Lorenzo Musetti game on 03/09/2025 of the current ATP US Open season:
- Jannik Sinner has a 83.71% chance to win against Lorenzo Musetti according to Unibet ⭐ with the odds of 1.07.
- Lorenzo Musetti has a 16.29% probability of winning facing Jannik Sinner ⭐ with odds of 12.8 at 22bet.
Jannik Sinner vs Lorenzo Musetti Best Prediction and Odds
Based on the bookmaker's betting lines in this match, Jannik Sinner has a 83.71 % chance to win.
Prediction | Chance to win |
---|---|
Jannik Sinner | 83.71 % |
Lorenzo Musetti | 16.29 % |
Jannik Sinner vs Lorenzo Musetti Form
Jannik Sinner and Lorenzo Musetti Last Matches
5/6 (83%)
1/6 (17%)
1 Sep 2025 - ATP US Open
30 Aug 2025 - ATP US Open
28 Aug 2025 - ATP US Open
26 Aug 2025 - ATP US Open
18 Aug 2025 - ATP Cincinnati Open
16 Aug 2025 - ATP Cincinnati Open
3/6 (50%)
3/6 (50%)
1 Sep 2025 - ATP US Open
30 Aug 2025 - ATP US Open
28 Aug 2025 - ATP US Open
26 Aug 2025 - ATP US Open
9 Aug 2025 - ATP Cincinnati Open
31 Jul 2025 - ATP Toronto
Jannik Sinner vs Lorenzo Musetti Stats: Head to Head (H2H)
100 %
0 %
21 Apr 2023 - ATP Barcelona
14 Apr 2023 - ATP Monte Carlo Masters
20 Oct 2021 - ATP European Open
Jannik Sinner - Lorenzo Musetti Key Points
- Sinner is on an 11-match winning streak at the US Open.
- Musetti lost both times he matched up with Sinner.
- Sinner has registered 16 victories in 17 hardcourt outings this season.
- Musetti lost both times he faced a top 10 player on a hard court this year.
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Our Jannik Sinner vs Lorenzo Musetti Prediction
Our prediction for Jannik Sinner v Lorenzo Musetti is for Sinner to win in straight sets. Sinner has been the best player at the US Open since last year’s campaign. As the defending champion, he has breezed past his opponents, winning 11 consecutive fixtures, eight by straight sets.
The Italian is the overwhelming favourite to win not only this tie with Musetti but the entire tournament. It is also worth noting that Sinner has won in straight sets both times he has been matched up against his compatriot.
Get a retirement guarantee for the Jannik Sinner vs. Lorenzo Musetti game!
When you place a bet on the match between Jannik Sinner and Lorenzo Musetti you can get a retirement guarantee with bet365. This means that your bet will be paid out as a winner if your opponent retires.
It does not matter whether you bet on Jannik Sinner or Lorenzo Musetti , if your opponent has to retire from the match with an injury, you will get paid as a winner!
All tips are fully researched and given in good faith, but profits cannot be guaranteed.

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