Anderlecht vs Lyon Prediction & Betting Tips - Europa League
Europe - Europa League
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by Sridhar Bhamidi | in Europa League Predictions
Anderlecht will hope to make the most of their home advantage as they begin their league phase of the 2026-27 UEFA Europa League (UEL) against Lyon on matchday one. This match at the Lotto Park on Wednesday between the ‘Purple & White’ and ’Les Gones’ could be a tight encounter, with under 2.5 goals remaining our match prediction.
The hosts have come through the qualifiers, starting from the second qualifying round. The visitors dropped down into the Europa League after losing in the UEFA Champions League playoffs against Fenerbahce.
Anderlecht edged out KV Mechelen 1-0 away from home last Friday for a fourth win in their last six matches (D1, L1). Two of those wins have come in the UEL qualifiers, where they thrashed Kairat Almaty 3-0 in each leg.
Strong home form is Anderlecht’s strength, as they remain unbeaten at home in all competitions (W5, D1), while keeping three clean sheets along the way.
Lyon come here on the back of a 0-0 away draw against Paris FC in Ligue 1. That was part of a four-game sequence where they could win just once (D2, L1) and lost to Fenerbahce in the Champions League. That defeat saw them drop down to the Europa League, but just one win from the last four trips (D2, L1) suggests things may not be straightforward for them.
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Anderlecht v Lyon Best Betting Odds
| Bookmaker | 1 | X | 2 | Bonus up to |
|---|---|---|---|---|
|
3.4 | 3.7 | 2.06 |
|
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3.57 | 3.78 | 2.06 |
|
|
3.5 | 3.7 | 2.01 |
|
|
3.5 | 3.7 | 2.01 |
|
|
3.52 | 3.72 | 2 |
|
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What is the prediction for the football match between Anderlecht and Lyon?
Our prediction for the Anderlecht vs Lyon match is: under 2.5 goals.
Probabilities according to our algorithm* of possible 1X2 football predictions and best odds for the match on 16/09/2026 between Anderlecht and Lyon in Europa League :
- The Sportytrader ⭐ algorithm estimates a probability of 50.43% for a win of Anderlecht against Lyon with odds of 3.65 at Betsson.
- The probability according to Sportytrader ⭐ for a draw between Anderlecht vs Lyon is 24.24% with odds of 3.78 at 1xbet.
- Our prediction model gives a 25.32% chance ⭐ for a win of Lyon vs Anderlecht with odds of 2.08 at Tonybet.
Anderlecht vs Lyon Form
Anderlecht and Lyon Last Matches
4/6 (67%)
1/6 (17%)
1/6 (17%)
Average stats (Last 6 matchs)
11 Sept 2026 - Jupiler Pro League
6 Sept 2026 - Jupiler Pro League
3 Sept 2026 - Jupiler Pro League
30 Aug 2026 - Jupiler Pro League
27 Aug 2026 - Europa League
20 Aug 2026 - Europa League
5/6 (83%)
1/6 (17%)
0/6 (0%)
Average stats (Last 6 matchs)
6 Sept 2026 - Jupiler Pro League
3 Sept 2026 - Jupiler Pro League
27 Aug 2026 - Europa League
13 Aug 2026 - Europa League
9 Aug 2026 - Jupiler Pro League
30 Jul 2026 - Europa League
3/6 (50%)
1/6 (17%)
2/6 (33%)
Average stats (Last 6 matchs)
11 Sept 2026 - Jupiler Pro League
30 Aug 2026 - Jupiler Pro League
20 Aug 2026 - Europa League
16 Aug 2026 - Jupiler Pro League
6 Aug 2026 - Europa League
23 Jul 2026 - Europa League
2/6 (33%)
3/6 (50%)
1/6 (17%)
Average stats (Last 6 matchs)
12 Sept 2026 - Ligue 1
4 Sept 2026 - Ligue 1
29 Aug 2026 - Ligue 1
26 Aug 2026 - Champions League
22 Aug 2026 - Ligue 1
18 Aug 2026 - Champions League
3/6 (50%)
1/6 (17%)
2/6 (33%)
Average stats (Last 6 matchs)
4 Sept 2026 - Ligue 1
29 Aug 2026 - Ligue 1
26 Aug 2026 - Champions League
11 Aug 2026 - Champions League
18 Jul 2026 - Clubs Friendlies
15 Jul 2026 - Clubs Friendlies
2/6 (33%)
2/6 (33%)
2/6 (33%)
Average stats (Last 6 matchs)
12 Sept 2026 - Ligue 1
22 Aug 2026 - Ligue 1
18 Aug 2026 - Champions League
4 Aug 2026 - Champions League
29 Jul 2026 - Clubs Friendlies
24 Jul 2026 - Clubs Friendlies
Anderlecht vs Lyon last Lineups
Formation : 4 - 4 - 2
Formation : 4 - 3 - 2 - 1
Substitutes
J. Heekeren
DefenderA. Omobamidele
MidfielderE. Llansana
T. Aasgaard
A. Romeo
T. Degreef
J. Nga Kana to
ForwardN. Ojea Cobiella
M. Cvetkovic
R. Descamps
DefenderC. Mata
R. Kluivert
N. Tagliafico
MidfielderN. Nartey
K. Boudache
K. Merah
T. Tessmann
K. Nakamura
Anderlecht - Lyon Key Points
- Anderlecht kept a clean sheet in five of their last six matches.
- Lyon scored exactly once in five of their last eight matches in Europe.
- Four of Lyon’s last six matches have featured under 2.5 goals.
- Anderlecht’s last three games featured less than two goals each time.
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Our Anderlecht vs Lyon Prediction
Lyon dropped to the Europa League after losing in the playoffs of the Champions League. While that gives them enough motivation to do well in this competition, Anderlecht won’t be ceding their home advantage easily. They have come through the qualifiers this year and have five wins from their last six home games in Europe, while keeping three clean sheets along the way.
Three of Lyon’s last four away matches in Europe ended with fewer than three goals, and that could repeat here. That’s why our Anderlecht vs Lyon prediction is under 2.5 goals.
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.
