Philadelphia 76ers vs Cleveland Cavaliers Prediction & Betting Tips - NBA

USA - NBA

Philadelphia 76ers
22/10/2026 19:00
Cleveland Cavaliers

Prediction :

 

Philadelphia 76ers wins

 
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 by Geoffrey Ejiga | in NBA Predictions

Cleveland arrive in Philadelphia for their opener, and our 76ers vs Cavaliers match prediction in this NBA clash is a home win. The 76ers already have a game behind them, having won 106-100 at the Knicks in their opener. While Cleveland begins their regular season at Wells Fargo Center.

The Cavaliers won only two of their final nine road games last season. The seven defeats included three in Toronto and two each in Detroit and New York. Cleveland also went 1-2 in the preseason, conceding 124 and 132 points in the two defeats. Those numbers suggest a visiting side still finding its rhythm.

However, the head-to-head record does lean toward the Cavaliers, who won six of the last seven meetings. The latest ended 115-101 in Cleveland's favor. That record matters less now that Philadelphia have signed both Lebron James and Jaylen Brown, in a fresh season where the 76ers have already started with a win.

We still keep in mind that Philadelphia's last eight home games of last season produced only three wins, so a close finish is likely.

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Philadelphia 76ers v Cleveland Cavaliers Best Betting Odds

Bookmaker 1 2 Bonus
1xbet
1.64 2.34
22bet
1.62 2.30
Bet365
1.65 2.30
Roobet
1.67 2.22
BC Game
1.67 2.22
Check all Philadelphia 76ers vs Cleveland Cavaliers odds

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Who will win the Philadelphia 76ers vs Cleveland Cavaliers Basketball game?

Our prediction for the Philadelphia 76ers vs Cleveland Cavaliers match is: Philadelphia 76ers win.

The best winner predictions and betting odds for the Philadelphia 76ers vs Cleveland Cavaliers game on 22/10/2026 of the current NBA season:

  • Philadelphia 76ers has a 51.33% chance to pick up the win against Cleveland Cavaliers according to Shangrila ⭐ with the odds of 1.72.
  • There is a probability of 48.67% ⭐ for Cleveland Cavaliers to win vs Philadelphia 76ers with odds of 2.34 at 1xbet.

Philadelphia 76ers vs Cleveland Cavaliers Form

Philadelphia 76ers and Cleveland Cavaliers's standings in the NBA

Teams % P W L Series
1 Philadelphia 76ers
1 1 1 0 1
15 Cleveland Cavaliers
0 0 0 0

Philadelphia 76ers and Cleveland Cavaliers Last Matches

Philadelphia 76ers
Philadelphia 76ers Last matches
W W L L L W
Wins

3/6 (50%)

Losses

3/6 (50%)

20 Oct 2026 - NBA

New York Knicks
100 :  106
Philadelphia 76ers

18 Jul 2026 - NBA Summer League

Milwaukee Bucks
96 :  94
Philadelphia 76ers

15 Jul 2026 - NBA Summer League

Philadelphia 76ers
92 :  99
Orlando Magic

14 Jul 2026 - NBA Summer League

Houston Rockets
90 :  64
Philadelphia 76ers

11 Jul 2026 - NBA Summer League

Philadelphia 76ers
100 :  93
Indiana Pacers

9 Jul 2026 - NBA Summer League

Philadelphia 76ers
101 :  93
Detroit Pistons
W L L W W L
Wins

3/6 (50%)

Losses

3/6 (50%)

15 Jul 2026 - NBA Summer League

Philadelphia 76ers
92 :  99
Orlando Magic

11 Jul 2026 - NBA Summer League

Philadelphia 76ers
100 :  93
Indiana Pacers

9 Jul 2026 - NBA Summer League

Philadelphia 76ers
101 :  93
Detroit Pistons

10 May 2026 - NBA

Philadelphia 76ers
114 :  144
New York Knicks

8 May 2026 - NBA

Philadelphia 76ers
94 :  108
New York Knicks

30 Apr 2026 - NBA

Philadelphia 76ers
106 :  93
Boston Celtics
W L L L L W
Wins

2/6 (33%)

Losses

4/6 (67%)

20 Oct 2026 - NBA

New York Knicks
100 :  106
Philadelphia 76ers

18 Jul 2026 - NBA Summer League

Milwaukee Bucks
96 :  94
Philadelphia 76ers

14 Jul 2026 - NBA Summer League

Houston Rockets
90 :  64
Philadelphia 76ers

6 May 2026 - NBA

New York Knicks
108 :  102
Philadelphia 76ers

4 May 2026 - NBA

New York Knicks
137 :  98
Philadelphia 76ers

2 May 2026 - NBA

Boston Celtics
100 :  109
Philadelphia 76ers
Cleveland Cavaliers
Cleveland Cavaliers Last matches
L L L W W W
Wins

3/6 (50%)

Losses

3/6 (50%)

17 Jul 2026 - NBA Summer League

Cleveland Cavaliers
100 :  91
Chicago Bulls

15 Jul 2026 - NBA Summer League

Cleveland Cavaliers
82 :  77
New Orleans Pelicans

13 Jul 2026 - NBA Summer League

Cleveland Cavaliers
90 :  73
Miami Heat

12 Jul 2026 - NBA Summer League

Detroit Pistons
103 :  94
Cleveland Cavaliers

10 Jul 2026 - NBA Summer League

Indiana Pacers
99 :  93
Cleveland Cavaliers

25 May 2026 - NBA

Cleveland Cavaliers
93 :  130
New York Knicks
L L L W W W
Wins

3/6 (50%)

Losses

3/6 (50%)

17 Jul 2026 - NBA Summer League

Cleveland Cavaliers
100 :  91
Chicago Bulls

15 Jul 2026 - NBA Summer League

Cleveland Cavaliers
82 :  77
New Orleans Pelicans

13 Jul 2026 - NBA Summer League

Cleveland Cavaliers
90 :  73
Miami Heat

25 May 2026 - NBA

Cleveland Cavaliers
93 :  130
New York Knicks

23 May 2026 - NBA

Cleveland Cavaliers
108 :  121
New York Knicks

15 May 2026 - NBA

Cleveland Cavaliers
94 :  115
Detroit Pistons
W W L L L L
Wins

2/6 (33%)

Losses

4/6 (67%)

12 Jul 2026 - NBA Summer League

Detroit Pistons
103 :  94
Cleveland Cavaliers

10 Jul 2026 - NBA Summer League

Indiana Pacers
99 :  93
Cleveland Cavaliers

21 May 2026 - NBA

New York Knicks
109 :  93
Cleveland Cavaliers

19 May 2026 - NBA

New York Knicks
115 :  104
Cleveland Cavaliers

17 May 2026 - NBA

Detroit Pistons
94 :  125
Cleveland Cavaliers

13 May 2026 - NBA

Detroit Pistons
113 :  117
Cleveland Cavaliers

Philadelphia 76ers vs Cleveland Cavaliers Stats: Head to Head (H2H)

Philadelphia 76ers

17 %

Cleveland Cavaliers

83 %

9 Mar 2026 - NBA

Cleveland Cavaliers
115 :  101
Philadelphia 76ers

16 Jan 2026 - NBA

Philadelphia 76ers
115 :  117
Cleveland Cavaliers

14 Jan 2026 - NBA

Philadelphia 76ers
107 :  133
Cleveland Cavaliers

5 Nov 2025 - NBA

Cleveland Cavaliers
132 :  121
Philadelphia 76ers

24 Jan 2025 - NBA

Philadelphia 76ers
132 :  129
Cleveland Cavaliers

21 Dec 2024 - NBA

Cleveland Cavaliers
126 :  99
Philadelphia 76ers
Philadelphia 76ers vs Cleveland Cavaliers Prediction

Players list

Philadelphia 76ers
Philadelphia 76ers
J. Brown J. Embiid

T. Maxey

V. Edgecombe

L. James

Cleveland Cavaliers
Cleveland Cavaliers
E. Udeh

J. Robinson

M. Thomas

M. Branham

R. Minix

Substitutes

Philadelphia 76ers
Philadelphia 76ers
A. Bona R. Rupert

K. Caldwell-Pope

A. Simons

C. Love

J. Edwards

L. Philon

J. Walker

Cleveland Cavaliers
Cleveland Cavaliers

D. Goodwin

S. East II

I. Martinez

X. Lee

R. Agee

T. Spillers

Philadelphia 76ers - Cleveland Cavaliers Key Points

  1. The 76ers won their season opener 106-100 at the Knicks.
  2. The Cavaliers won only two of their final nine road games last season.
  3. The Cavaliers won six of the last seven meetings, with the latest a 115-101 win.
  4. The 76ers now field Lebron James and Jalyen Brown, alongside Joel Embiid and VJ Edgecombe.
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Our Philadelphia 76ers vs Cleveland Cavaliers Prediction

Philadelphia hosts Cleveland after a 106-100 opening win at the Knicks. The Cavaliers haven’t seen action yet, but they notably lost seven of their final nine road games last season. 

Cleveland won six of the last seven meetings, but this is a brand new 76ers' team with a competent home record. The margin may be thin, but it should be a Philly win either way. Hence, our 76ers vs Cavaliers prediction is that the Philadelphia 76ers win.

Prediction :

 

Philadelphia 76ers wins

 
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.