Kansas City Chiefs vs Denver Broncos Prediction & Picks - NFL
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by Matt Lowrimore | in NFL Picks
Week 1 of the NFL will conclude on Monday Night with a matchup between the Kansas City Chiefs and the Denver Broncos. Let’s take a look at the match statistics and predictions for this AFC West game between the Chiefs and the Broncos.
Denver enters this game having finished with a record of 14-3 in 2025-2026 and in 1st place in the AFC West Division. The Broncos beat the Buffalo Bills in the AFC Divisional Round before losing to the New England Patriots in the AFC Championship game. Most notably, Denver returns Bo Nix under center after he suffered a late injury last season, and one of the best defenses in the league, which could give the Chiefs’ offense trouble to open the season.
As for Kansas City, they enter this game having finished with a record of 6-11 in 2025-2026. The Chiefs missed the playoffs for the first time in a long time, largely due to the fact that their quarterback, Patrick Mahomes, was injured and missed significant time.
That said, Mahomes appears to be healthy now and is expected to be back for this matchup, which greatly increases the Chiefs’ chances of opening their season with a win.
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Kansas City Chiefs vs Denver Broncos Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
3
|
0 | 0 | 0 | 0 |
|
3
|
0 | 0 | 0 | 0 |
Kansas City Chiefs and Denver Broncos Latest Matches
0/6 (0%)
6/6 (100%)
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3/6 (50%)
3/6 (50%)
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6/6 (100%)
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4/6 (67%)
2/6 (33%)
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4/6 (67%)
2/6 (33%)
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6/6 (100%)
0/6 (0%)
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Kansas City Chiefs against Denver Broncos : Head to Head (H2H)
33 %
67 %
Dec 25, 2025 - NFL
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Kansas City Chiefs - Denver Broncos Key Points
- Denver was 2-0 SU against Kansas City in 2025-2026
- Denver was 2-0 ATS against Kansas City in 2025-2026
- Denver allowed 18.3 points per game in 2025-2026
- Kansas City averaged 21.3 points per game in 2025-2026
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Our Kansas City Chiefs vs Denver Broncos Prediction
Kansas City is the small favorite in this game; however, Denver looks to be the best betting option. For one, the Broncos beat the Chiefs in both regular-season meetings in 2025-2026. Granted, Chiefs’ quarterback Patrick Mahomes was out for most of the season.
That said, the Broncos’ defense was still among the best in the league last season. Denver allowed just 18.3 points per game, so even though Mahomes is likely going to be back for this game, there is a chance that he will not be 100%.
For that reason, our Kansas City Chiefs vs. Denver Broncos prediction is: Denver Broncos +3.5 Alternate Spread.
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.
