Detroit Lions vs New Orleans Saints Prediction & Picks - NFL

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Detroit Lions
9/13/26 13:00
New Orleans Saints

Prediction:

 

New Orleans +7

-110
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 by Bill Christy | in NFL Picks

The 2025-2026 season was disappointing for both the Detroit Lions and the New Orleans Saints. The Saints finished with a 6-11 mark and while the expectations were low, the 6 wins was still a disappointment. For the Lions, they had high hopes but failed to live up to the hype. They finished 9-8 and missed out on the postseason. On Sunday afternoon, these two teams will kickoff their 2025-2026 seasons as the Lions will play hosts.

This season, the hype in Detroit is back to a fever pitch and many expect them to make a large improvement in the win column this season. They have arguably the most versatile and explosive running backs in the league in Jahmyr Gibbs. He will get an even larger load this season as they lost David Montgomery to Houston in the offseason. However, Gibbs on the ground and Amon-Ra St. Brown through the air is enough weapons for any offense.

The Saints are not expected to be a true contender this season. However, they did bring in Travis Etienne from Jacksonville to make up for the aging and injury-ridden Alvin Kamara. Tyler Shough is set to be the starter and should provide some juice and youth to the offense. He will have one of the top receivers in the league to throw to in Chris Olave. Brandon Staley made some additions to the defense and they should be improved from last season

Detroit Lions vs New Orleans Saints Form

Table

Teams Pts P W L
3 New Orleans Saints
0 0 0 0
3 Detroit Lions
0 0 0 0

Detroit Lions and New Orleans Saints Latest Matches

Detroit Lions
Detroit Lions Latest matches
L W L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Jan 4, 2026 - NFL

Chicago Bears
16 :  19
Detroit Lions

Dec 25, 2025 - NFL

Minnesota Vikings
23 :  10
Detroit Lions

Dec 21, 2025 - NFL

Detroit Lions
24 :  29
Pittsburgh Steelers

Dec 14, 2025 - NFL

Los Angeles Rams
41 :  34
Detroit Lions

Dec 4, 2025 - NFL

Detroit Lions
44 :  30
Dallas Cowboys

Nov 27, 2025 - NFL

Detroit Lions
24 :  31
Green Bay Packers
W L W L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Dec 21, 2025 - NFL

Detroit Lions
24 :  29
Pittsburgh Steelers

Dec 4, 2025 - NFL

Detroit Lions
44 :  30
Dallas Cowboys

Nov 27, 2025 - NFL

Detroit Lions
24 :  31
Green Bay Packers

Nov 23, 2025 - NFL

Detroit Lions
34 :  27
New York Giants

Nov 2, 2025 - NFL

Detroit Lions
24 :  27
Minnesota Vikings

Oct 20, 2025 - NFL

Detroit Lions
24 :  9
Tampa Bay Buccaneers
L W L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Jan 4, 2026 - NFL

Chicago Bears
16 :  19
Detroit Lions

Dec 25, 2025 - NFL

Minnesota Vikings
23 :  10
Detroit Lions

Dec 14, 2025 - NFL

Los Angeles Rams
41 :  34
Detroit Lions

Nov 16, 2025 - NFL

Philadelphia Eagles
16 :  9
Detroit Lions

Nov 9, 2025 - NFL

Washington Commanders
22 :  44
Detroit Lions

Oct 12, 2025 - NFL

Kansas City Chiefs
30 :  17
Detroit Lions
New Orleans Saints
New Orleans Saints Latest matches
L W W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Jan 4, 2026 - NFL

Atlanta Falcons
19 :  17
New Orleans Saints

Dec 28, 2025 - NFL

Tennessee Titans
26 :  34
New Orleans Saints

Dec 21, 2025 - NFL

New Orleans Saints
29 :  6
New York Jets

Dec 14, 2025 - NFL

New Orleans Saints
20 :  17
Carolina Panthers

Dec 7, 2025 - NFL

Tampa Bay Buccaneers
20 :  24
New Orleans Saints

Nov 30, 2025 - NFL

Miami Dolphins
21 :  17
New Orleans Saints
W L L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Dec 21, 2025 - NFL

New Orleans Saints
29 :  6
New York Jets

Dec 14, 2025 - NFL

New Orleans Saints
20 :  17
Carolina Panthers

Nov 23, 2025 - NFL

New Orleans Saints
10 :  24
Atlanta Falcons

Oct 26, 2025 - NFL

New Orleans Saints
3 :  23
Tampa Bay Buccaneers

Oct 12, 2025 - NFL

New Orleans Saints
19 :  25
New England Patriots

Oct 5, 2025 - NFL

New Orleans Saints
26 :  14
New York Giants
L W L W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jan 4, 2026 - NFL

Atlanta Falcons
19 :  17
New Orleans Saints

Dec 28, 2025 - NFL

Tennessee Titans
26 :  34
New Orleans Saints

Dec 7, 2025 - NFL

Tampa Bay Buccaneers
20 :  24
New Orleans Saints

Nov 30, 2025 - NFL

Miami Dolphins
21 :  17
New Orleans Saints

Nov 9, 2025 - NFL

Carolina Panthers
7 :  17
New Orleans Saints

Nov 2, 2025 - NFL

Los Angeles Rams
34 :  10
New Orleans Saints

Detroit Lions against New Orleans Saints : Head to Head (H2H)

Detroit Lions

100 %

New Orleans Saints

0 %

Dec 3, 2023 - NFL

New Orleans Saints
28 :  33
Detroit Lions
Detroit Lions vs New Orleans Saints Picks

Detroit Lions - New Orleans Saints Key Points

  1. Lions are 1-3 ATS in their last 4 games.
  2. Lions are 1-4 ATS in their last 5 at home as favorites.
  3. Saints are 4-0 ATS in their last 4 games as a road underdog.
  4. Saints are 6-0 ATS in their last 6 games overall.

Our Detroit Lions vs New Orleans Saints Prediction

The Saints were one of the best teams against the spread towards the end of last season. We like them to continue that type of play to start the season here in Detroit. While the Lions are one of the best offenses in the league, we believe the defense will struggle against this revitalized Saints offense in the opener. The Lions should pull out the win but we expect the Saints to cover the number.

Our prediction for Detroit Lions vs New Orleans Saints: New Orleans +7

Prediction:

 

New Orleans +7

-110
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.