New York Giants vs Arizona Cardinals Prediction & Picks - NFL

USA - NFL

New York Giants
10/4/26 13:00
Arizona Cardinals

Prediction:

 

Under 44.5 points

-112
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 by Lou Aguila in NFL Picks

The New York Giants and the Arizona Cardinals will go head-to-head in a match between two teams in the bottom half of the NFL in points per game.

Current Form:

The New York Giants are off to a promising start after winning 2 of their first 3 games this season. The Giants opened their season with a 28-20 win over the Dallas Cowboys, lost to the Los Angeles Rams 6-28 on Week 2 and grinded out a 12-7 win over the Tennessee Titans on Week 3.

After stunning the LA Chargers 26-14 on Week 1, the Arizona Cardinals suffered back-to-back defeats to the Seattle Seahawks 7-31 and the San Francisco 49ers 30-36.

The Matchup: The Cardinals are 5-3 in their head-to-head series against the Giants. The last time these two clashed, the Giants came away with a 31-28 win on September 17, 2023.

New York Giants vs Arizona Cardinals Form

Table

Teams Pts P W L
14 New York Giants
0.667 3 2 1
27 Arizona Cardinals
0.333 3 1 2

New York Giants and Arizona Cardinals Latest Matches

New York Giants
New York Giants Latest matches
L W W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 27, 2026 - NFL

New York Giants
12 :  7
Tennessee Titans

Sep 21, 2026 - NFL

Los Angeles Rams
28 :  6
New York Giants

Sep 13, 2026 - NFL

New York Giants
28 :  20
Dallas Cowboys

Jan 4, 2026 - NFL

New York Giants
34 :  17
Dallas Cowboys

Dec 28, 2025 - NFL

Las Vegas Raiders
10 :  34
New York Giants

Dec 21, 2025 - NFL

New York Giants
13 :  16
Minnesota Vikings
L L L W W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 27, 2026 - NFL

New York Giants
12 :  7
Tennessee Titans

Sep 13, 2026 - NFL

New York Giants
28 :  20
Dallas Cowboys

Jan 4, 2026 - NFL

New York Giants
34 :  17
Dallas Cowboys

Dec 21, 2025 - NFL

New York Giants
13 :  16
Minnesota Vikings

Dec 14, 2025 - NFL

New York Giants
21 :  29
Washington Commanders

Nov 16, 2025 - NFL

New York Giants
20 :  27
Green Bay Packers
L L L L W L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Sep 21, 2026 - NFL

Los Angeles Rams
28 :  6
New York Giants

Dec 28, 2025 - NFL

Las Vegas Raiders
10 :  34
New York Giants

Dec 1, 2025 - NFL

New England Patriots
33 :  15
New York Giants

Nov 23, 2025 - NFL

Detroit Lions
34 :  27
New York Giants

Nov 9, 2025 - NFL

Chicago Bears
24 :  20
New York Giants

Oct 26, 2025 - NFL

Philadelphia Eagles
38 :  20
New York Giants
Arizona Cardinals
Arizona Cardinals Latest matches
L L L W L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Sep 27, 2026 - NFL

San Francisco 49ers
36 :  30
Arizona Cardinals

Sep 20, 2026 - NFL

Arizona Cardinals
7 :  31
Seattle Seahawks

Sep 13, 2026 - NFL

Los Angeles Chargers
14 :  26
Arizona Cardinals

Jan 4, 2026 - NFL

Los Angeles Rams
37 :  20
Arizona Cardinals

Dec 28, 2025 - NFL

Cincinnati Bengals
37 :  14
Arizona Cardinals

Dec 21, 2025 - NFL

Arizona Cardinals
19 :  26
Atlanta Falcons
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

Sep 20, 2026 - NFL

Arizona Cardinals
7 :  31
Seattle Seahawks

Dec 21, 2025 - NFL

Arizona Cardinals
19 :  26
Atlanta Falcons

Dec 7, 2025 - NFL

Arizona Cardinals
17 :  45
Los Angeles Rams

Nov 23, 2025 - NFL

Arizona Cardinals
24 :  27
Jacksonville Jaguars

Nov 16, 2025 - NFL

Arizona Cardinals
22 :  41
San Francisco 49ers

Oct 19, 2025 - NFL

Arizona Cardinals
23 :  27
Green Bay Packers
L L L L W L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Sep 27, 2026 - NFL

San Francisco 49ers
36 :  30
Arizona Cardinals

Sep 13, 2026 - NFL

Los Angeles Chargers
14 :  26
Arizona Cardinals

Jan 4, 2026 - NFL

Los Angeles Rams
37 :  20
Arizona Cardinals

Dec 28, 2025 - NFL

Cincinnati Bengals
37 :  14
Arizona Cardinals

Dec 14, 2025 - NFL

Houston Texans
40 :  20
Arizona Cardinals

Nov 30, 2025 - NFL

Tampa Bay Buccaneers
20 :  17
Arizona Cardinals

New York Giants against Arizona Cardinals : Head to Head (H2H)

New York Giants

100 %

Arizona Cardinals

0 %

Sep 17, 2023 - NFL

Arizona Cardinals
28 :  31
New York Giants
New York Giants vs Arizona Cardinals Picks

New York Giants - Arizona Cardinals Key Points

  1. The Cardinals average 21.0 points per game this season.
  2. The Cardinals average 303.0 total yards per game this season.
  3. The Giants average 271.3 total yards per game this season.
  4. The Giants average 15.3 points per game this season.

Our New York Giants vs Arizona Cardinals Prediction

Key Stats: These two teams land in the bottom half of the league in points per game. The Cardinals and Giants have averaged 36.3 combined points per game through the first 3 weeks of the season.

What to Expect: The Cardinals edge the Giants in a low-scoring ballgame. Arizona will try to exploit the absence of Giants starting quarterback Jaxson Dart, who suffered a knee injury in a loss to the Rams. The Giants got the win last week with Jamies Winston as their starting quarterback, but New York only scored 12 points in that game as the they opted for conservative tactics rather than engaging in a high-risk shootout against Tennessee.

The Cardinals have also been running high-percentage plays for their quarterback Jacoby Brissett. Arizona’s reliance on short passes and ground game reduces the percentage of making errors but it almost prevents them from creating explosive plays.

Fearless Forecast: Cardinals 17, Giants 13

Our betting prediction for the Arizona Cardinals vs. the New York Giants: Under 44.5 points

Prediction:

 

Under 44.5 points

-112
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.