San Francisco 49ers vs Denver Broncos Prediction & Picks - NFL

Prediction published on 10/2/26, 4:25 PM  by Bill Christy | Modified on 10/2/26 at 4:30 PM in NFL Picks

The San Francisco 49ers are undefeated despite the laundry list of injuries they have already been dealing with in the early part of the season. Sunday, they face another team that has been playing solid football, the Denver Broncos.

Denver is coming off an impressive 30-26 come-from-behind win over the Los Angeles Rams last week. Talanoa Hufanga picked off Matthew Stafford to take a lead before Stafford came right back and drove the Rams down for a touchdown and a 26-23 lead with just 3:30 left in the game. Bo Nix then led a game-winning drive in which he capped it off with a touchdown run of his own to win the game. Their only loss was to Kansas City, who is still undefeated.

The 49ers are finding ways to win despite injuries to key players each week. They dominated the Rams in week one and have since taken care of business against the Dolphins and Cardinals. Brock Purdy has put himself in the early race for MVP as he is completing 72% of his passes for nearly 800 yards, 9 touchdowns, and just 1 interception. His QBR is an astounding 133.1, and he is playing like a high-level veteran. On the other side, the 49ers defense is 3rd in the league in points allowed per game (16.7).