Washington Commanders vs Indianapolis Colts Prediction & Picks - NFL
USA - NFL
New customers only | Commercial content | 21+ age limit | T&Cs apply
by Matt Lowrimore | in NFL Picks
Week 4 of the NFL continues on Sunday with a full slate of games, one of which will see the Washington Commanders take on the Indianapolis Colts in London, England. Let’s take a look at the match statistics and predictions for this game between the Commanders and the Colts.
Washington enters this game with a record of 1-2. The Commanders pulled a big upset in Week 3, as they beat the Seattle Seahawks by a score of 33-31. In this game, Washington mustered just 258 yards of total offense, while allowing 437 yards. The biggest news coming into this week is that Commanders quarterback Jayden Daniels has been ruled out. This means that Marcus Mariota will once again be the starter. Note that Mariota was under center in the Week 3 win and played well enough without making any mistakes, suggesting he will be able to do the same against an inconsistent Colts’ defense.
As for Indianapolis, they also enter this game with a record of 1-2. The Colts picked up their first win in Week 3 as well, as they beat the Houston Texans by a score of 19-17. Despite winning the game, the Indianapolis offense was unimpressive and could have issues against Washington.
Limited Offer. Currently at DraftKings
Washington Commanders vs Indianapolis Colts Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
18
|
0.333 | 3 | 1 | 2 |
|
25
|
0.333 | 3 | 1 | 2 |
Washington Commanders and Indianapolis Colts Latest Matches
2/6 (33%)
4/6 (67%)
Sep 27, 2026 - NFL
Sep 20, 2026 - NFL
Sep 13, 2026 - NFL
Jan 4, 2026 - NFL
Dec 25, 2025 - NFL
Dec 20, 2025 - NFL
1/6 (17%)
5/6 (83%)
Sep 27, 2026 - NFL
Dec 25, 2025 - NFL
Dec 20, 2025 - NFL
Nov 30, 2025 - NFL
Nov 9, 2025 - NFL
Nov 2, 2025 - NFL
2/6 (33%)
4/6 (67%)
Sep 20, 2026 - NFL
Sep 13, 2026 - NFL
Jan 4, 2026 - NFL
Dec 14, 2025 - NFL
Dec 7, 2025 - NFL
Nov 16, 2025 - NFL
1/6 (17%)
5/6 (83%)
Sep 27, 2026 - NFL
Sep 20, 2026 - NFL
Sep 13, 2026 - NFL
Jan 4, 2026 - NFL
Dec 28, 2025 - NFL
Dec 22, 2025 - NFL
2/6 (33%)
4/6 (67%)
Sep 27, 2026 - NFL
Sep 13, 2026 - NFL
Dec 28, 2025 - NFL
Dec 22, 2025 - NFL
Nov 30, 2025 - NFL
Nov 9, 2025 - NFL
0/6 (0%)
6/6 (100%)
Sep 20, 2026 - NFL
Jan 4, 2026 - NFL
Dec 14, 2025 - NFL
Dec 7, 2025 - NFL
Nov 23, 2025 - NFL
Nov 2, 2025 - NFL
Washington Commanders against Indianapolis Colts : Head to Head (H2H)
100 %
0 %
Oct 30, 2022 - NFL
Washington Commanders - Indianapolis Colts Key Points
- Washington is 2-1 ATS this season
- Washington is averaging 25.0 points per game this season
- Indianapolis is averaging 24.0 points per game this season
- Indianapolis is 2-1 ATS this season
Limited Offer. Currently at DraftKings
Our Washington Commanders vs Indianapolis Colts Prediction
The Colts are the clear favorite in this game; however, the Commanders look to be the best betting option. This goes back to how inconsistent the Colts’ offense has already been this season. Indianapolis is averaging 24.0 points per game, but has had two games where they scored less than this average. As for their defense, the Colts are allowing 30.3 points per game, which includes allowing 41 points to the Baltimore Ravens and 33 points to the Kansas City Chiefs.
Washington, on the other hand, is averaging 25.0 points per game this season. On defense, the Commanders are allowing an average of 30.7 points per game. That said, Washington was more than impressive in Week 3; therefore, our Washington Commanders vs. Indianapolis Colts prediction is: Washington Commanders +4.5.
A Welcome Bonus for Washington Commanders vs Indianapolis Colts!

Looking to place a bet on Washington Commanders vs Indianapolis Colts? For this NFL match, DraftKings will treat you to an exclusive offer: $150 in bonus bets, no promo code needed! Take advantage while you still can!
All tips are fully researched and given in good faith, but profits cannot be guaranteed.