Washington Commanders vs Indianapolis Colts Prediction & Picks - NFL

USA - NFL

Washington Commanders
10/4/26 09:30
Indianapolis Colts

Prediction:

 

Washington Commanders +4.5

-115
$150 offered for betting!

New customers only | Commercial content | 21+ age limit | T&Cs apply

 by Matt Lowrimore | in NFL Picks

Week 4 of the NFL continues on Sunday with a full slate of games, one of which will see the Washington Commanders take on the Indianapolis Colts in London, England. Let’s take a look at the match statistics and predictions for this game between the Commanders and the Colts.

Washington enters this game with a record of 1-2. The Commanders pulled a big upset in Week 3, as they beat the Seattle Seahawks by a score of 33-31. In this game, Washington mustered just 258 yards of total offense, while allowing 437 yards. The biggest news coming into this week is that Commanders quarterback Jayden Daniels has been ruled out. This means that Marcus Mariota will once again be the starter. Note that Mariota was under center in the Week 3 win and played well enough without making any mistakes, suggesting he will be able to do the same against an inconsistent Colts’ defense.

As for Indianapolis, they also enter this game with a record of 1-2. The Colts picked up their first win in Week 3 as well, as they beat the Houston Texans by a score of 19-17. Despite winning the game, the Indianapolis offense was unimpressive and could have issues against Washington.

Washington Commanders vs Indianapolis Colts Form

Table

Teams Pts P W L
18 Washington Commanders
0.333 3 1 2
25 Indianapolis Colts
0.333 3 1 2

Washington Commanders and Indianapolis Colts Latest Matches

Washington Commanders
Washington Commanders Latest matches
L L W L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 27, 2026 - NFL

Washington Commanders
33 :  31
Seattle Seahawks

Sep 20, 2026 - NFL

Dallas Cowboys
37 :  20
Washington Commanders

Sep 13, 2026 - NFL

Philadelphia Eagles
24 :  22
Washington Commanders

Jan 4, 2026 - NFL

Philadelphia Eagles
17 :  24
Washington Commanders

Dec 25, 2025 - NFL

Washington Commanders
23 :  30
Dallas Cowboys

Dec 20, 2025 - NFL

Washington Commanders
18 :  29
Philadelphia Eagles
L L L L L W
Victories

1/6 (17%)

Defeats

5/6 (83%)

Sep 27, 2026 - NFL

Washington Commanders
33 :  31
Seattle Seahawks

Dec 25, 2025 - NFL

Washington Commanders
23 :  30
Dallas Cowboys

Dec 20, 2025 - NFL

Washington Commanders
18 :  29
Philadelphia Eagles

Nov 30, 2025 - NFL

Washington Commanders
26 :  27
Denver Broncos

Nov 9, 2025 - NFL

Washington Commanders
22 :  44
Detroit Lions

Nov 2, 2025 - NFL

Washington Commanders
14 :  38
Seattle Seahawks
L L W W L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 20, 2026 - NFL

Dallas Cowboys
37 :  20
Washington Commanders

Sep 13, 2026 - NFL

Philadelphia Eagles
24 :  22
Washington Commanders

Jan 4, 2026 - NFL

Philadelphia Eagles
17 :  24
Washington Commanders

Dec 14, 2025 - NFL

New York Giants
21 :  29
Washington Commanders

Dec 7, 2025 - NFL

Minnesota Vikings
31 :  0
Washington Commanders

Nov 16, 2025 - NFL

Miami Dolphins
16 :  13
Washington Commanders
Indianapolis Colts
Indianapolis Colts Latest matches
L L L L L W
Victories

1/6 (17%)

Defeats

5/6 (83%)

Sep 27, 2026 - NFL

Indianapolis Colts
19 :  17
Houston Texans

Sep 20, 2026 - NFL

Kansas City Chiefs
33 :  30
Indianapolis Colts

Sep 13, 2026 - NFL

Indianapolis Colts
23 :  41
Baltimore Ravens

Jan 4, 2026 - NFL

Houston Texans
38 :  30
Indianapolis Colts

Dec 28, 2025 - NFL

Indianapolis Colts
17 :  23
Jacksonville Jaguars

Dec 22, 2025 - NFL

Indianapolis Colts
27 :  48
San Francisco 49ers
W L L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 27, 2026 - NFL

Indianapolis Colts
19 :  17
Houston Texans

Sep 13, 2026 - NFL

Indianapolis Colts
23 :  41
Baltimore Ravens

Dec 28, 2025 - NFL

Indianapolis Colts
17 :  23
Jacksonville Jaguars

Dec 22, 2025 - NFL

Indianapolis Colts
27 :  48
San Francisco 49ers

Nov 30, 2025 - NFL

Indianapolis Colts
16 :  20
Houston Texans

Nov 9, 2025 - NFL

Indianapolis Colts
31 :  25
Atlanta Falcons
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

Sep 20, 2026 - NFL

Kansas City Chiefs
33 :  30
Indianapolis Colts

Jan 4, 2026 - NFL

Houston Texans
38 :  30
Indianapolis Colts

Dec 14, 2025 - NFL

Seattle Seahawks
18 :  16
Indianapolis Colts

Dec 7, 2025 - NFL

Jacksonville Jaguars
36 :  19
Indianapolis Colts

Nov 23, 2025 - NFL

Kansas City Chiefs
23 :  20
Indianapolis Colts

Nov 2, 2025 - NFL

Pittsburgh Steelers
27 :  20
Indianapolis Colts

Washington Commanders against Indianapolis Colts : Head to Head (H2H)

Washington Commanders

100 %

Indianapolis Colts

0 %

Oct 30, 2022 - NFL

Indianapolis Colts
16 :  17
Washington Commanders
Washington Commanders vs Indianapolis Colts Picks

Washington Commanders - Indianapolis Colts Key Points

  1. Washington is 2-1 ATS this season
  2. Washington is averaging 25.0 points per game this season
  3. Indianapolis is averaging 24.0 points per game this season
  4. Indianapolis is 2-1 ATS this season

Our Washington Commanders vs Indianapolis Colts Prediction

The Colts are the clear favorite in this game; however, the Commanders look to be the best betting option. This goes back to how inconsistent the Colts’ offense has already been this season. Indianapolis is averaging 24.0 points per game, but has had two games where they scored less than this average. As for their defense, the Colts are allowing 30.3 points per game, which includes allowing 41 points to the Baltimore Ravens and 33 points to the Kansas City Chiefs.

Washington, on the other hand, is averaging 25.0 points per game this season. On defense, the Commanders are allowing an average of 30.7 points per game. That said, Washington was more than impressive in Week 3; therefore, our Washington Commanders vs. Indianapolis Colts prediction is: Washington Commanders +4.5.

Prediction:

 

Washington Commanders +4.5

-115
$150 offered for betting!

A Welcome Bonus for Washington Commanders vs Indianapolis Colts!

DraftKings Welcome Bonus 150

Looking to place a bet on Washington Commanders vs Indianapolis Colts? For this NFL match, DraftKings will treat you to an exclusive offer: $150 in bonus bets, no promo code needed! Take advantage while you still can!

$150 in bonus bets for Washington Commanders vs Indianapolis Colts!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.