Seattle Seahawks vs San Francisco 49ers Prediction & Picks - NFL
USA - NFL
New customers only | Commercial content | 21+ age limit | T&Cs apply
by Carlos Zabala | in NFL Picks
The 49ers have a perfect 4-0 record so far in the 2016-2027 NFL season, which included a victory in Melbourne, Australia, against the Rams. At the start of October, they defeated the Broncos 24-14 and now face a road game at Lumen Field against the reigning NFL champions, the Seahawks. They faced each other twice in January of this year during the previous season, with Seattle winning only the first game: 13-3 and 41-6 in the playoffs.
The reigning NFL champions have a 3-1 record after defeating the Chargers 30-23; it was a game in which, despite winning, the Seahawks themselves were their own worst enemies. Seattle committed a franchise-record 150 penalty yards and 14 flags. Sam Darnold had a solid night, completing 13 of 22 passes for 2 touchdowns and 1 interception.
This lack of discipline in Seattle's defense has narrowed the gap in the pregame odds for Sunday's 49ers-Seahawks game; this is also due to how well Brock Purdy's pocket has looked, as he has yet to be sacked this season. His quickness when time runs out is also a credit to him.
Limited Offer. Currently at FanDuel
Seattle Seahawks vs San Francisco 49ers Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
3
|
1 | 4 | 4 | 0 |
|
8
|
0.75 | 4 | 3 | 1 |
Seattle Seahawks and San Francisco 49ers Latest Matches
5/6 (83%)
1/6 (17%)
Oct 4, 2026 - NFL
Sep 27, 2026 - NFL
Sep 20, 2026 - NFL
Sep 9, 2026 - NFL
Feb 8, 2026 - NFL
Jan 25, 2026 - NFL
6/6 (100%)
0/6 (0%)
Oct 4, 2026 - NFL
Sep 9, 2026 - NFL
Jan 25, 2026 - NFL
Jan 17, 2026 - NFL
Dec 18, 2025 - NFL
Dec 14, 2025 - NFL
5/6 (83%)
1/6 (17%)
Sep 27, 2026 - NFL
Sep 20, 2026 - NFL
Feb 8, 2026 - NFL
Jan 3, 2026 - NFL
Dec 28, 2025 - NFL
Dec 7, 2025 - NFL
5/6 (83%)
1/6 (17%)
Oct 4, 2026 - NFL
Sep 27, 2026 - NFL
Sep 20, 2026 - NFL
Sep 10, 2026 - NFL
Jan 17, 2026 - NFL
Jan 11, 2026 - NFL
5/6 (83%)
1/6 (17%)
Oct 4, 2026 - NFL
Sep 27, 2026 - NFL
Sep 20, 2026 - NFL
Jan 3, 2026 - NFL
Dec 28, 2025 - NFL
Dec 14, 2025 - NFL
5/6 (83%)
1/6 (17%)
Sep 10, 2026 - NFL
Jan 17, 2026 - NFL
Jan 11, 2026 - NFL
Dec 22, 2025 - NFL
Nov 30, 2025 - NFL
Nov 16, 2025 - NFL
Seattle Seahawks against San Francisco 49ers : Head to Head (H2H)
50 %
50 %
Jan 17, 2026 - NFL
Jan 3, 2026 - NFL
Sep 7, 2025 - NFL
Nov 17, 2024 - NFL
Oct 10, 2024 - NFL
Nov 23, 2023 - NFL
Seattle Seahawks - San Francisco 49ers Key Points
- Christian McCaffrey of the 49ers has 218 yards this season
- The 49ers have the best 3rd down conversion rate in the NFL at 57.5%
- Both the Seahawks and 49ers are among the top five defenses in the NFL that allow the fewest points per game
- The 49ers have won 7 of their last 10 meetings against the Seahawks
Limited Offer. Currently at FanDuel
Our Seattle Seahawks vs San Francisco 49ers Prediction
The Seahawks are the reigning champions, but despite winning three games, they haven't looked as convincing as they did last year. They've struggled on third downs, converting only 31.1% so far, and they're coming off a near-blow of a 21-point lead in their last game.
Purdy has already reached 1,007 yards this year, completing 79 of 113 passes, supported by a group of veteran receivers over 30 years old who have proven to have great chemistry with the 26-year-old quarterback.
Our prediction for Seahawks vs 49ers is: 49ers ML.
Welcome Bonus for the Seattle Seahawks vs San Francisco 49ers match!
FanDuel is offering some great promos for the beginning of football season, including their welcome offer of $250, which can be activated for this Seattle Seahawks vs San Francisco 49ers match! Simply sign up and place a first bet of at least $5. You can do this during your first 5 days with FanDuel, earning a total of $250 in bet reset tokens!
Remember, the offer is only open to new sign-ups!
All tips are fully researched and given in good faith, but profits cannot be guaranteed.
