Pittsburgh Steelers vs Indianapolis Colts Prediction & Picks - NFL

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Pittsburgh Steelers
10/11/26 13:00
Indianapolis Colts

Prediction:

 

Steelers -3

-105
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 by Travis Pulver | in NFL Picks

The Pittsburgh Steelers (2-2, 2-0 Home) will try to stay perfect at home Sunday when they host the Indianapolis Colts (2-2, 1-1 Away) at Acrisure Stadium in the Steel City. Kickoff for this AFC battle is scheduled for 1 p.m. EST and will be broadcast on CBS.

If Pittsburgh fans thought the offense would click with Aaron Rodgers reuniting with his former Green Bay Packers head coach, Mike McCarthy, well—it hasn’t. Rodgers isn’t even completing 60% of his passes (57.5) and has thrown seven touchdowns to four interceptions. After two lackluster games to start the season, he has had two back-to-back 290+ yard efforts. But the second was because the Steelers were playing catch-up against the Browns (the Browns!). The run game has been all over the place with a low of 58 yards and a high of 138.

As for the Colts, after a Week 1 disaster vs. the Ravens (41-23) and a tough loss to the Chiefs, they’ve bounced back to win two in a row. The competition wasn’t tough (Houston, Washington), but they’ve built momentum heading into this game that could help them get off to a quick start against a Steelers team that plays its best football at home.

Pittsburgh Steelers vs Indianapolis Colts Form

Table

Teams Pts P W L
15 Pittsburgh Steelers
0.5 4 2 2
20 Indianapolis Colts
0.5 4 2 2

Pittsburgh Steelers and Indianapolis Colts Latest Matches

Pittsburgh Steelers
Pittsburgh Steelers Latest matches
W L W L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Oct 1, 2026 - NFL

Cleveland Browns
27 :  24
Pittsburgh Steelers

Sep 27, 2026 - NFL

Pittsburgh Steelers
30 :  27
Cincinnati Bengals

Sep 20, 2026 - NFL

New England Patriots
20 :  3
Pittsburgh Steelers

Sep 13, 2026 - NFL

Pittsburgh Steelers
20 :  13
Atlanta Falcons

Jan 12, 2026 - NFL

Pittsburgh Steelers
6 :  30
Houston Texans

Jan 4, 2026 - NFL

Pittsburgh Steelers
26 :  24
Baltimore Ravens
L W W L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 27, 2026 - NFL

Pittsburgh Steelers
30 :  27
Cincinnati Bengals

Sep 13, 2026 - NFL

Pittsburgh Steelers
20 :  13
Atlanta Falcons

Jan 12, 2026 - NFL

Pittsburgh Steelers
6 :  30
Houston Texans

Jan 4, 2026 - NFL

Pittsburgh Steelers
26 :  24
Baltimore Ravens

Dec 15, 2025 - NFL

Pittsburgh Steelers
28 :  15
Miami Dolphins

Nov 30, 2025 - NFL

Pittsburgh Steelers
7 :  26
Buffalo Bills
L W W L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Oct 1, 2026 - NFL

Cleveland Browns
27 :  24
Pittsburgh Steelers

Sep 20, 2026 - NFL

New England Patriots
20 :  3
Pittsburgh Steelers

Dec 28, 2025 - NFL

Cleveland Browns
13 :  6
Pittsburgh Steelers

Dec 21, 2025 - NFL

Detroit Lions
24 :  29
Pittsburgh Steelers

Dec 7, 2025 - NFL

Baltimore Ravens
22 :  27
Pittsburgh Steelers

Nov 23, 2025 - NFL

Chicago Bears
31 :  28
Pittsburgh Steelers
Indianapolis Colts
Indianapolis Colts Latest matches
L L L L W W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Oct 4, 2026 - NFL

Washington Commanders
13 :  30
Indianapolis Colts

Sep 27, 2026 - NFL

Indianapolis Colts
19 :  17
Houston Texans

Sep 20, 2026 - NFL

Kansas City Chiefs
33 :  30
Indianapolis Colts

Sep 13, 2026 - NFL

Indianapolis Colts
23 :  41
Baltimore Ravens

Jan 4, 2026 - NFL

Houston Texans
38 :  30
Indianapolis Colts

Dec 28, 2025 - NFL

Indianapolis Colts
17 :  23
Jacksonville Jaguars
W L L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 27, 2026 - NFL

Indianapolis Colts
19 :  17
Houston Texans

Sep 13, 2026 - NFL

Indianapolis Colts
23 :  41
Baltimore Ravens

Dec 28, 2025 - NFL

Indianapolis Colts
17 :  23
Jacksonville Jaguars

Dec 22, 2025 - NFL

Indianapolis Colts
27 :  48
San Francisco 49ers

Nov 30, 2025 - NFL

Indianapolis Colts
16 :  20
Houston Texans

Nov 9, 2025 - NFL

Indianapolis Colts
31 :  25
Atlanta Falcons
L L L L L W
Victories

1/6 (17%)

Defeats

5/6 (83%)

Oct 4, 2026 - NFL

Washington Commanders
13 :  30
Indianapolis Colts

Sep 20, 2026 - NFL

Kansas City Chiefs
33 :  30
Indianapolis Colts

Jan 4, 2026 - NFL

Houston Texans
38 :  30
Indianapolis Colts

Dec 14, 2025 - NFL

Seattle Seahawks
18 :  16
Indianapolis Colts

Dec 7, 2025 - NFL

Jacksonville Jaguars
36 :  19
Indianapolis Colts

Nov 23, 2025 - NFL

Kansas City Chiefs
23 :  20
Indianapolis Colts

Pittsburgh Steelers against Indianapolis Colts : Head to Head (H2H)

Pittsburgh Steelers

50 %

Indianapolis Colts

50 %

Nov 2, 2025 - NFL

Pittsburgh Steelers
27 :  20
Indianapolis Colts

Sep 29, 2024 - NFL

Indianapolis Colts
27 :  24
Pittsburgh Steelers

Dec 16, 2023 - NFL

Indianapolis Colts
30 :  13
Pittsburgh Steelers

Nov 28, 2022 - NFL

Indianapolis Colts
17 :  24
Pittsburgh Steelers
Pittsburgh Steelers vs Indianapolis Colts Picks

Pittsburgh Steelers - Indianapolis Colts Key Points

  1. Aaron Rodgers will not have former Colts wide receiver Michael Pittman Jr. available; Jalen Ramsey and Rico Dowdle are questionable.
  2. Daniel Jones may be down two weapons, as receivers Darius Slayton and Keenan Allen are questionable.
  3. The Colts' defense has improved over the last couple of weeks but still allows an average of 261.3 passing yards and 131 rushing yards per game.
  4. Betting Public:  35% of spread tickets and 39% of the handle are on the Steelers.

Our Pittsburgh Steelers vs Indianapolis Colts Prediction

This is a tough one. Aaron Rodgers and the Steelers offense haven't been very impressive, but neither have Daniel Jones and the Colts offense. Indy has a slight advantage with Jonathan Taylor in the backfield. But given how the Indianapolis defense has played, Jaylen Warren may remind fans of Taylor. If Rodgers can pick up his game and look like a shadow of his former self, Pittsburgh should be able to beat the Colts by more than a field goal.

Our Indianapolis vs. Pittsburgh Pick: Steelers -2.5

Prediction:

 

Steelers -3

-105
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.