Arizona Cardinals vs Detroit Lions Prediction & Picks - NFL

USA - NFL

Arizona Cardinals
10/11/26 16:25
Detroit Lions

Prediction:

 

Lions -5.5

-105
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 by Carlos Zabala | in NFL Picks

The Lions, with a 2-2 record, travel to State Farm Stadium to face the 1-3 Cardinals. This will be Detroit's first divisional opponent of the year, coming off a 32-26 loss to the Panthers. Arizona, meanwhile, has lost three games after winning their season opener; they fell 36-24 to the Giants on October 4.

In the loss to Carolina, Gauff threw for 412 yards and connected with LaPorta for a touchdown. They had a very strong offensive performance that dipped slightly in the fourth game. Even so, Gauff has yet to be intercepted this year, and Amon-Ra St. Brown and Jahmyr Gibbs are among the NFL's top 10 in rushing and receiving yards.

The Cardinals, in addition to their frustrating loss to the Giants, lost Paris Johnson Jr. to injury. Arizona's offense seems to function only in very short bursts, especially when QB Jacoby Brissett connects with Michael Wilson. Even so, and despite playing at home, the Cardinals remain heavy underdogs in the betting odds, and the Cardinals haven't beaten the Lions since 2011.

Arizona Cardinals vs Detroit Lions Form

Table

Teams Pts P W L
18 Detroit Lions
0.5 4 2 2
26 Arizona Cardinals
0.25 4 1 3

Arizona Cardinals and Detroit Lions Latest Matches

Arizona Cardinals
Arizona Cardinals Latest matches
L L W L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Oct 4, 2026 - NFL

New York Giants
36 :  24
Arizona Cardinals

Sep 27, 2026 - NFL

San Francisco 49ers
36 :  30
Arizona Cardinals

Sep 20, 2026 - NFL

Arizona Cardinals
7 :  31
Seattle Seahawks

Sep 13, 2026 - NFL

Los Angeles Chargers
14 :  26
Arizona Cardinals

Jan 4, 2026 - NFL

Los Angeles Rams
37 :  20
Arizona Cardinals

Dec 28, 2025 - NFL

Cincinnati Bengals
37 :  14
Arizona Cardinals
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

Sep 20, 2026 - NFL

Arizona Cardinals
7 :  31
Seattle Seahawks

Dec 21, 2025 - NFL

Arizona Cardinals
19 :  26
Atlanta Falcons

Dec 7, 2025 - NFL

Arizona Cardinals
17 :  45
Los Angeles Rams

Nov 23, 2025 - NFL

Arizona Cardinals
24 :  27
Jacksonville Jaguars

Nov 16, 2025 - NFL

Arizona Cardinals
22 :  41
San Francisco 49ers

Oct 19, 2025 - NFL

Arizona Cardinals
23 :  27
Green Bay Packers
L L L W L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Oct 4, 2026 - NFL

New York Giants
36 :  24
Arizona Cardinals

Sep 27, 2026 - NFL

San Francisco 49ers
36 :  30
Arizona Cardinals

Sep 13, 2026 - NFL

Los Angeles Chargers
14 :  26
Arizona Cardinals

Jan 4, 2026 - NFL

Los Angeles Rams
37 :  20
Arizona Cardinals

Dec 28, 2025 - NFL

Cincinnati Bengals
37 :  14
Arizona Cardinals

Dec 14, 2025 - NFL

Houston Texans
40 :  20
Arizona Cardinals
Detroit Lions
Detroit Lions Latest matches
L W W L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Oct 4, 2026 - NFL

Carolina Panthers
32 :  26
Detroit Lions

Sep 27, 2026 - NFL

Detroit Lions
31 :  24
New York Jets

Sep 17, 2026 - NFL

Buffalo Bills
41 :  31
Detroit Lions

Sep 13, 2026 - NFL

Detroit Lions
31 :  30
New Orleans Saints

Jan 4, 2026 - NFL

Chicago Bears
16 :  19
Detroit Lions

Dec 25, 2025 - NFL

Minnesota Vikings
23 :  10
Detroit Lions
W L W L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 27, 2026 - NFL

Detroit Lions
31 :  24
New York Jets

Sep 13, 2026 - NFL

Detroit Lions
31 :  30
New Orleans Saints

Dec 21, 2025 - NFL

Detroit Lions
24 :  29
Pittsburgh Steelers

Dec 4, 2025 - NFL

Detroit Lions
44 :  30
Dallas Cowboys

Nov 27, 2025 - NFL

Detroit Lions
24 :  31
Green Bay Packers

Nov 23, 2025 - NFL

Detroit Lions
34 :  27
New York Giants
L L L W L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Oct 4, 2026 - NFL

Carolina Panthers
32 :  26
Detroit Lions

Sep 17, 2026 - NFL

Buffalo Bills
41 :  31
Detroit Lions

Jan 4, 2026 - NFL

Chicago Bears
16 :  19
Detroit Lions

Dec 25, 2025 - NFL

Minnesota Vikings
23 :  10
Detroit Lions

Dec 14, 2025 - NFL

Los Angeles Rams
41 :  34
Detroit Lions

Nov 16, 2025 - NFL

Philadelphia Eagles
16 :  9
Detroit Lions

Arizona Cardinals against Detroit Lions : Head to Head (H2H)

Arizona Cardinals

0 %

Detroit Lions

100 %

Sep 22, 2024 - NFL

Arizona Cardinals
13 :  20
Detroit Lions
Arizona Cardinals vs Detroit Lions Picks

Arizona Cardinals - Detroit Lions Key Points

  1. Lions are the worst in the NL in yards per game
  2. Cardinals have an 0-2 record against divisional opponents this season
  3. Jacoby Brissett has been intercepted four times this season
  4. Lions are third in passing yards this season with 287.2

Our Arizona Cardinals vs Detroit Lions Prediction

In comparison, Lions QB Jared Goff has 1,214 yards this season, throwing for nine touchdowns with no interceptions, while Brissett has already been intercepted four times and thrown for only six touchdowns.

In 2024, it was the last time the Lions visited the Cardinals, where they achieved a 20-13 away victory, in a game where Jared Goff himself completed 18 of 23 passes.

Our prediction for Cardinals vs Lions is: Lions -5.5.

Prediction:

 

Lions -5.5

-105
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.