Cleveland Guardians vs Chicago White Sox Prediction & Picks - MLB

USA - MLB

Cleveland Guardians
10/10/26 17:00
Chicago White Sox

Prediction:

 

Under 7.5 Total Runs

-134
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 by Matt Lowrimore | in MLB Picks

The MLB playoffs continue on Saturday with one game to determine the second team in the ALCS. This will be Game 5 in the ALDS between the Cleveland Guardians and the Chicago White Sox. Let’s take a look at the match statistics and predictions for this game between the Guardians and the White Sox.

Chicago enters this game having already blown a 2-0 lead in this series. The good news is that they won both Game 1 and Game 2 on the road, the venue for this winner-take-all Game 5. Most notably, both of the games previously played in Cleveland were dominated by White Sox pitching. If they are going to avoid a collapse, Chicago must have a similar performance here.

As for Cleveland, they appear to have all the momentum and have the luxury of being back at home. The Guardians’ offense also looks to have come alive in Game 3 and Game 4, as they scored nine runs in both games, while scoring just three runs total in Games 1 and 2.

Cleveland Guardians vs Chicago White Sox Form

Cleveland Guardians and Chicago White Sox Latest Matches

Cleveland Guardians
Cleveland Guardians Latest matches
W L L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Oct 8, 2026 - MLB

Chicago White Sox
5 :  9
Cleveland Guardians

Oct 7, 2026 - MLB

Chicago White Sox
3 :  9
Cleveland Guardians

Oct 5, 2026 - MLB

Cleveland Guardians
3 :  4
Chicago White Sox

Oct 3, 2026 - MLB

Cleveland Guardians
0 :  3
Chicago White Sox

Sep 27, 2026 - MLB

Kansas City Royals
3 :  2
Cleveland Guardians

Sep 26, 2026 - MLB

Kansas City Royals
5 :  11
Cleveland Guardians
W W W W L L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Oct 5, 2026 - MLB

Cleveland Guardians
3 :  4
Chicago White Sox

Oct 3, 2026 - MLB

Cleveland Guardians
0 :  3
Chicago White Sox

Sep 20, 2026 - MLB

Cleveland Guardians
1 :  0
Athletics

Sep 19, 2026 - MLB

Cleveland Guardians
12 :  6
Athletics

Sep 18, 2026 - MLB

Cleveland Guardians
5 :  3
Athletics

Sep 16, 2026 - MLB

Cleveland Guardians
6 :  3
Chicago White Sox
W W W L W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Oct 8, 2026 - MLB

Chicago White Sox
5 :  9
Cleveland Guardians

Oct 7, 2026 - MLB

Chicago White Sox
3 :  9
Cleveland Guardians

Sep 27, 2026 - MLB

Kansas City Royals
3 :  2
Cleveland Guardians

Sep 26, 2026 - MLB

Kansas City Royals
5 :  11
Cleveland Guardians

Sep 25, 2026 - MLB

Kansas City Royals
9 :  12
Cleveland Guardians

Sep 24, 2026 - MLB

Boston Red Sox
0 :  1
Cleveland Guardians
Chicago White Sox
Chicago White Sox Latest matches
W W W W L L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Oct 8, 2026 - MLB

Chicago White Sox
5 :  9
Cleveland Guardians

Oct 7, 2026 - MLB

Chicago White Sox
3 :  9
Cleveland Guardians

Oct 5, 2026 - MLB

Cleveland Guardians
3 :  4
Chicago White Sox

Oct 3, 2026 - MLB

Cleveland Guardians
0 :  3
Chicago White Sox

Sep 30, 2026 - MLB

Houston Astros
3 :  7
Chicago White Sox

Sep 29, 2026 - MLB

Houston Astros
3 :  6
Chicago White Sox
W W L W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Oct 8, 2026 - MLB

Chicago White Sox
5 :  9
Cleveland Guardians

Oct 7, 2026 - MLB

Chicago White Sox
3 :  9
Cleveland Guardians

Sep 27, 2026 - MLB

Chicago White Sox
4 :  2
Colorado Rockies

Sep 26, 2026 - MLB

Chicago White Sox
6 :  9
Colorado Rockies

Sep 25, 2026 - MLB

Chicago White Sox
6 :  1
Colorado Rockies

Sep 20, 2026 - MLB

Chicago White Sox
8 :  1
Detroit Tigers
L W W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Oct 5, 2026 - MLB

Cleveland Guardians
3 :  4
Chicago White Sox

Oct 3, 2026 - MLB

Cleveland Guardians
0 :  3
Chicago White Sox

Sep 30, 2026 - MLB

Houston Astros
3 :  7
Chicago White Sox

Sep 29, 2026 - MLB

Houston Astros
3 :  6
Chicago White Sox

Sep 24, 2026 - MLB

Kansas City Royals
1 :  9
Chicago White Sox

Sep 23, 2026 - MLB

Kansas City Royals
5 :  4
Chicago White Sox

Cleveland Guardians against Chicago White Sox : Head to Head (H2H)

Cleveland Guardians

67 %

Chicago White Sox

33 %

Oct 8, 2026 - MLB

Chicago White Sox
5 :  9
Cleveland Guardians

Oct 7, 2026 - MLB

Chicago White Sox
3 :  9
Cleveland Guardians

Oct 5, 2026 - MLB

Cleveland Guardians
3 :  4
Chicago White Sox

Oct 3, 2026 - MLB

Cleveland Guardians
0 :  3
Chicago White Sox

Sep 16, 2026 - MLB

Cleveland Guardians
6 :  3
Chicago White Sox

Sep 15, 2026 - MLB

Cleveland Guardians
7 :  6
Chicago White Sox
Cleveland Guardians vs Chicago White Sox Picks

Cleveland Guardians - Chicago White Sox Key Points

  1. Chicago is averaging 3.5 runs per game on the road in this series
  2. The Under is 2-2 in this series
  3. Cleveland is averaging 1.5 runs per game at home this series
  4. The Under is 2-0 in Cleveland in this series

Our Cleveland Guardians vs Chicago White Sox Prediction

Cleveland is the clear favorite in this game; however, the under looks to be the best betting option. For one, this game is likely to have much more tension compared to earlier in the series, as it is now a winner-take-all to advance to the ALCS against the Tampa Bay Rays. Further, both of the previous games played in Cleveland in this series were low-scoring, and as such, the under is 2-0 in those games.

In Game 1 and Game 2, an average of 5 total runs were scored per game; therefore, given what is at stake, our Cleveland Guardians vs. Chicago White Sox prediction is: Under 7.5 Total Runs.

Prediction:

 

Under 7.5 Total Runs

-134
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.