Los Angeles Chargers vs Denver Broncos Prediction & Picks - NFL
USA - NFL
New customers only | Commercial content | 21+ age limit | T&Cs apply
by Lou Aguila | in NFL Picks
The Denver Broncos have a clear path to cover -3.0 points against the Los Angeles Chargers, who will miss several key players in this Week 5 matchup.
Current Form:
The Denver Broncos are 2-2 through the first four weeks of the 2026-27 NFL season. After absorbing a 10-31 beatdown at the hands of the Kansas City Chiefs, the Broncos claimed wins over the Jacksonville Jaguars 20-13 and the Los Angeles Rams 30-26. The Broncos failed to make it three wins in a row, succumbing to the red-hot San Francisco 49ers in Week 4.
Meanwhile, the Los Angeles Chargers have lost their first four games of the season. The Chargers had not scored more than 16 points in their first three games before scoring 23 in a loss to the Seattle Seahawks, 23-30.
The Matchup: The Broncos snapped their three-game losing streak against the Chargers with a 19-3 rout last January.
Limited Offer. Currently at DraftKings
Los Angeles Chargers vs Denver Broncos Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
13
|
0.5 | 4 | 2 | 2 |
|
30
|
0 | 4 | 0 | 4 |
Los Angeles Chargers and Denver Broncos Latest Matches
0/6 (0%)
6/6 (100%)
Oct 4, 2026 - NFL
Sep 27, 2026 - NFL
Sep 20, 2026 - NFL
Sep 13, 2026 - NFL
Jan 11, 2026 - NFL
Jan 4, 2026 - NFL
3/6 (50%)
3/6 (50%)
Sep 20, 2026 - NFL
Sep 13, 2026 - NFL
Dec 27, 2025 - NFL
Dec 8, 2025 - NFL
Nov 30, 2025 - NFL
Nov 9, 2025 - NFL
2/6 (33%)
4/6 (67%)
Oct 4, 2026 - NFL
Sep 27, 2026 - NFL
Jan 11, 2026 - NFL
Jan 4, 2026 - NFL
Dec 21, 2025 - NFL
Dec 14, 2025 - NFL
3/6 (50%)
3/6 (50%)
Oct 4, 2026 - NFL
Sep 27, 2026 - NFL
Sep 20, 2026 - NFL
Sep 14, 2026 - NFL
Jan 25, 2026 - NFL
Jan 17, 2026 - NFL
4/6 (67%)
2/6 (33%)
Sep 27, 2026 - NFL
Sep 20, 2026 - NFL
Jan 25, 2026 - NFL
Jan 17, 2026 - NFL
Jan 4, 2026 - NFL
Dec 21, 2025 - NFL
4/6 (67%)
2/6 (33%)
Oct 4, 2026 - NFL
Sep 14, 2026 - NFL
Dec 25, 2025 - NFL
Dec 7, 2025 - NFL
Nov 30, 2025 - NFL
Nov 2, 2025 - NFL
Los Angeles Chargers against Denver Broncos : Head to Head (H2H)
50 %
50 %
Jan 4, 2026 - NFL
Sep 21, 2025 - NFL
Dec 19, 2024 - NFL
Oct 13, 2024 - NFL
Dec 31, 2023 - NFL
Dec 10, 2023 - NFL
Los Angeles Chargers - Denver Broncos Key Points
- The Broncos average 18.5 points per game this season.
- The Broncos average 23.5 points allowed per game this season.
- The Chargers average 16.8 points per game this season.
- The Chargers average 26.5 points allowed per game this season.
Limited Offer. Currently at DraftKings
Our Los Angeles Chargers vs Denver Broncos Prediction
The Difference Maker: The Chargers’ offensive line is decimated coming into this divisional matchup with the Broncos. Los Angeles will miss the services of offensive tackle Joe Alt (neck) and left tackle Rashawn Slater (high-ankle sprain). This could leave quarterback Justin Herbert vulnerable to the Broncos’ aggressive pass-rushing unit led by Nik Bonitto and Zach Allen. Moreover, the Chargers will play without starting wideout Quentin Johnston (Chest), leaving quarterback Justin Herbert without his primary targets downfield.
What to Expect: The Broncos breeze through to a comfortable win over the Chargers. Denver should dominate the line of scrimmage with the Chargers missing key pieces of their offensive line. The Chargers were already struggling to score points this season, but with Justin Herbert missing several targets and line protectors, creating scoring plays will prove brutally hard for the Chargers QB.
Fearless Forecast: The Broncos 35, the Chargers 19
Our betting prediction for the Denver Broncos vs. the LA Chargers: The Broncos -3.0 points
A Welcome Bonus for Los Angeles Chargers vs Denver Broncos!

Looking to place a bet on Los Angeles Chargers vs Denver Broncos? For this NFL match, DraftKings will treat you to an exclusive offer: $150 in bonus bets, no promo code needed! Take advantage while you still can!
All tips are fully researched and given in good faith, but profits cannot be guaranteed.