San Francisco 49ers vs Las Vegas Raiders Prediction & Picks - NFL

USA - NFL

San Francisco 49ers
11/8/26 16:25
Las Vegas Raiders

Prediction:

 

OVER 51.5

−120
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 by Travis Pulver in NFL Picks

For the first time since leaving Oakland following the 2019 season when the team moved to Las Vegas, the Raiders (4-4, 3-1 Away) are back in the Bay Area Sunday to take on the San Francisco 49ers (6-1, 4-0 Home) at Levi’s Stadium in Santa Clara, CA. Kickoff is scheduled for 4:25 p.m. EST with coverage provided by Fox.

San Francisco will come into the game well-rested off a bye week. They will still be without wide receivers Mike Evans and Deebo Samuel, though. Despite the injuries, the 49ers have been clicking on offense, averaging 371.4 yards (No. 6) and 28.1 points per game (No. 5). Their defense has been performing at a high level as well, allowing 19.9 points per game (No. 6).

Las Vegas got off to a hot start this season with three wins out of the gate, which they followed up with four consecutive losses. They were able to get back on the right side of the scoreboard last week in a barnburner against the New York Jets (38-33). On offense, the Raiders are averaging 27.7 points a game (No. 6) but are giving up 28.8 points per game this season (No. 31).

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San Francisco 49ers vs Las Vegas Raiders Form

Table

Teams Pts P W L
1 San Francisco 49ers
0.857 7 6 1
17 Las Vegas Raiders
0.5 8 4 4

San Francisco 49ers and Las Vegas Raiders Latest Matches

San Francisco 49ers
San Francisco 49ers Latest matches
W W W W W L
Victories

5/6 (83%)

Defeats

1/6 (17%)

Oct 25, 2026 - NFL

Atlanta Falcons
29 :  20
San Francisco 49ers

Oct 19, 2026 - NFL

San Francisco 49ers
23 :  17
Washington Commanders

Oct 11, 2026 - NFL

Seattle Seahawks
29 :  32
San Francisco 49ers

Oct 4, 2026 - NFL

San Francisco 49ers
24 :  14
Denver Broncos

Sep 27, 2026 - NFL

San Francisco 49ers
36 :  30
Arizona Cardinals

Sep 20, 2026 - NFL

San Francisco 49ers
35 :  13
Miami Dolphins
W L W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Oct 19, 2026 - NFL

San Francisco 49ers
23 :  17
Washington Commanders

Oct 4, 2026 - NFL

San Francisco 49ers
24 :  14
Denver Broncos

Sep 27, 2026 - NFL

San Francisco 49ers
36 :  30
Arizona Cardinals

Sep 20, 2026 - NFL

San Francisco 49ers
35 :  13
Miami Dolphins

Jan 3, 2026 - NFL

San Francisco 49ers
3 :  13
Seattle Seahawks

Dec 28, 2025 - NFL

San Francisco 49ers
42 :  38
Chicago Bears
W W L W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Oct 25, 2026 - NFL

Atlanta Falcons
29 :  20
San Francisco 49ers

Oct 11, 2026 - NFL

Seattle Seahawks
29 :  32
San Francisco 49ers

Sep 10, 2026 - NFL

Los Angeles Rams
7 :  27
San Francisco 49ers

Jan 17, 2026 - NFL

Seattle Seahawks
41 :  6
San Francisco 49ers

Jan 11, 2026 - NFL

Philadelphia Eagles
19 :  23
San Francisco 49ers

Dec 22, 2025 - NFL

Indianapolis Colts
27 :  48
San Francisco 49ers
Las Vegas Raiders
Las Vegas Raiders Latest matches
W L L L L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Nov 1, 2026 - NFL

New York Jets
33 :  38
Las Vegas Raiders

Oct 25, 2026 - NFL

Las Vegas Raiders
21 :  35
Los Angeles Rams

Oct 18, 2026 - NFL

Las Vegas Raiders
30 :  33
Buffalo Bills

Oct 11, 2026 - NFL

New England Patriots
45 :  17
Las Vegas Raiders

Oct 4, 2026 - NFL

Las Vegas Raiders
27 :  30
Kansas City Chiefs

Sep 27, 2026 - NFL

New Orleans Saints
27 :  35
Las Vegas Raiders
L W W L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Oct 25, 2026 - NFL

Las Vegas Raiders
21 :  35
Los Angeles Rams

Oct 18, 2026 - NFL

Las Vegas Raiders
30 :  33
Buffalo Bills

Oct 4, 2026 - NFL

Las Vegas Raiders
27 :  30
Kansas City Chiefs

Sep 13, 2026 - NFL

Las Vegas Raiders
27 :  13
Miami Dolphins

Jan 4, 2026 - NFL

Las Vegas Raiders
14 :  12
Kansas City Chiefs

Dec 28, 2025 - NFL

Las Vegas Raiders
10 :  34
New York Giants
L L W W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Nov 1, 2026 - NFL

New York Jets
33 :  38
Las Vegas Raiders

Oct 11, 2026 - NFL

New England Patriots
45 :  17
Las Vegas Raiders

Sep 27, 2026 - NFL

New Orleans Saints
27 :  35
Las Vegas Raiders

Sep 20, 2026 - NFL

Los Angeles Chargers
14 :  26
Las Vegas Raiders

Dec 21, 2025 - NFL

Houston Texans
23 :  21
Las Vegas Raiders

Dec 14, 2025 - NFL

Philadelphia Eagles
31 :  0
Las Vegas Raiders

San Francisco 49ers against Las Vegas Raiders : Head to Head (H2H)

San Francisco 49ers

100 %

Las Vegas Raiders

0 %

Jan 1, 2023 - NFL

Las Vegas Raiders
34 :  37
San Francisco 49ers
San Francisco 49ers vs Las Vegas Raiders Picks

San Francisco 49ers - Las Vegas Raiders Key Points

  1. In four career games against the 49ers, Kirk Cousins has completed 66.67% of his passes, averaging just under 300 yards per game and 8 touchdowns.
  2. Brock Purdy went 22-of-35 for 284 yards and two touchdowns in his one previous start vs. the Raiders (January 1, 2023).
  3. Betting Public: 52% of spread tickets and 54% of the handle are on the 49ers.
  4. Betting Public: 70% of total tickets and 77% of the stake are on the OVER.

Our San Francisco 49ers vs Las Vegas Raiders Prediction

When your team has a high-scoring offense but is struggling on the defensive side of the ball, you are going to be in for a lot of high-scoring games—like the Raiders. After starting the season with a pair of UNDERS, the OVER has paid for Las Vegas the last six games.  I don't expect their offense to be as prolific against a tough 49ers defense, but with the 49ers probably scoring 30+ points against the Raiders' poor defense, they’ll make up the difference and push the final score OVER this total.

Our Raiders vs. 49ers Pick: OVER 51.5

Prediction:

 

OVER 51.5

−120
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.