San Francisco 49ers vs Las Vegas Raiders Prediction & Picks - NFL
USA - NFL
New customers only | Commercial content | 21+ age limit | T&Cs apply
by Travis Pulver in NFL Picks
For the first time since leaving Oakland following the 2019 season when the team moved to Las Vegas, the Raiders (4-4, 3-1 Away) are back in the Bay Area Sunday to take on the San Francisco 49ers (6-1, 4-0 Home) at Levi’s Stadium in Santa Clara, CA. Kickoff is scheduled for 4:25 p.m. EST with coverage provided by Fox.
San Francisco will come into the game well-rested off a bye week. They will still be without wide receivers Mike Evans and Deebo Samuel, though. Despite the injuries, the 49ers have been clicking on offense, averaging 371.4 yards (No. 6) and 28.1 points per game (No. 5). Their defense has been performing at a high level as well, allowing 19.9 points per game (No. 6).
Las Vegas got off to a hot start this season with three wins out of the gate, which they followed up with four consecutive losses. They were able to get back on the right side of the scoreboard last week in a barnburner against the New York Jets (38-33). On offense, the Raiders are averaging 27.7 points a game (No. 6) but are giving up 28.8 points per game this season (No. 31).
Limited Offer. Currently at DraftKings
Our editorial team's top-confidence pick, every day.
Members only · free sign-up
San Francisco 49ers vs Las Vegas Raiders Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
1
|
0.857 | 7 | 6 | 1 |
|
17
|
0.5 | 8 | 4 | 4 |
San Francisco 49ers and Las Vegas Raiders Latest Matches
5/6 (83%)
1/6 (17%)
Oct 25, 2026 - NFL
Oct 19, 2026 - NFL
Oct 11, 2026 - NFL
Oct 4, 2026 - NFL
Sep 27, 2026 - NFL
Sep 20, 2026 - NFL
5/6 (83%)
1/6 (17%)
Oct 19, 2026 - NFL
Oct 4, 2026 - NFL
Sep 27, 2026 - NFL
Sep 20, 2026 - NFL
Jan 3, 2026 - NFL
Dec 28, 2025 - NFL
4/6 (67%)
2/6 (33%)
Oct 25, 2026 - NFL
Oct 11, 2026 - NFL
Sep 10, 2026 - NFL
Jan 17, 2026 - NFL
Jan 11, 2026 - NFL
Dec 22, 2025 - NFL
2/6 (33%)
4/6 (67%)
Nov 1, 2026 - NFL
Oct 25, 2026 - NFL
Oct 18, 2026 - NFL
Oct 11, 2026 - NFL
Oct 4, 2026 - NFL
Sep 27, 2026 - NFL
2/6 (33%)
4/6 (67%)
Oct 25, 2026 - NFL
Oct 18, 2026 - NFL
Oct 4, 2026 - NFL
Sep 13, 2026 - NFL
Jan 4, 2026 - NFL
Dec 28, 2025 - NFL
3/6 (50%)
3/6 (50%)
Nov 1, 2026 - NFL
Oct 11, 2026 - NFL
Sep 27, 2026 - NFL
Sep 20, 2026 - NFL
Dec 21, 2025 - NFL
Dec 14, 2025 - NFL
San Francisco 49ers against Las Vegas Raiders : Head to Head (H2H)
100 %
0 %
Jan 1, 2023 - NFL
San Francisco 49ers - Las Vegas Raiders Key Points
- In four career games against the 49ers, Kirk Cousins has completed 66.67% of his passes, averaging just under 300 yards per game and 8 touchdowns.
- Brock Purdy went 22-of-35 for 284 yards and two touchdowns in his one previous start vs. the Raiders (January 1, 2023).
- Betting Public: 52% of spread tickets and 54% of the handle are on the 49ers.
- Betting Public: 70% of total tickets and 77% of the stake are on the OVER.
Limited Offer. Currently at DraftKings
Our San Francisco 49ers vs Las Vegas Raiders Prediction
When your team has a high-scoring offense but is struggling on the defensive side of the ball, you are going to be in for a lot of high-scoring games—like the Raiders. After starting the season with a pair of UNDERS, the OVER has paid for Las Vegas the last six games. I don't expect their offense to be as prolific against a tough 49ers defense, but with the 49ers probably scoring 30+ points against the Raiders' poor defense, they’ll make up the difference and push the final score OVER this total.
Our Raiders vs. 49ers Pick: OVER 51.5
A Welcome Bonus for San Francisco 49ers vs Las Vegas Raiders!

Looking to place a bet on San Francisco 49ers vs Las Vegas Raiders? For this NFL match, DraftKings will treat you to an exclusive offer: $200 in bonus bets, no promo code needed! Take advantage while you still can!
All tips are fully researched and given in good faith, but profits cannot be guaranteed.