Indianapolis Colts vs Dallas Cowboys Prediction & Picks - NFL
USA - NFL
Prediction:
The Cowboys -5.5 points + OVER 51.5 points (2-leg parlay)
New customers only | Commercial content | 21+ age limit | T&Cs apply
by Lou Aguila | in NFL Picks
A +252 payout is up for grabs on Sunday as the Dallas Cowboys and the Indianapolis Colts duke it out in what many expect to be another high-scoring ballgame.
Current Form:
The Dallas Cowboys have gone 1-3 in their last 4 games, including a heartbreaking 30-33 overtime loss to the Arizona Cardinals last week. Poor defense remains a major issue for the Cowboys. Dallas ranks 26th in the NFL in points allowed per game (26.6) and worst in the league in total yards allowed per game (385.4).
Meanwhile, the Indianapolis Colts have lost their last four games. The latest blow came in the form of a 7-42 beatdown by the Jacksonville Jaguars. Indianapolis ranks third-to-last in points allowed per game (27.8) and 25th in rushing yards allowed per game (131.8).
The Matchup: Dallas is 4-1 vs. Indianapolis in their last 5 meetings. The last time they faced each other, the Cowboys blew out the Colts 54-19 in a high-scoring ballgame on December 4, 2022.
Limited Offer. Currently at DraftKings
Our editorial team's top-confidence pick, every day.
Members only · free sign-up
Indianapolis Colts vs Dallas Cowboys Form
Table
| Teams | Pts | P | W | L |
|---|---|---|---|---|
|
23
|
0.375 | 8 | 3 | 5 |
|
28
|
0.25 | 8 | 2 | 6 |
Indianapolis Colts and Dallas Cowboys Latest Matches
2/6 (33%)
4/6 (67%)
Nov 1, 2026 - NFL
Oct 25, 2026 - NFL
Oct 18, 2026 - NFL
Oct 11, 2026 - NFL
Oct 4, 2026 - NFL
Sep 27, 2026 - NFL
1/6 (17%)
5/6 (83%)
Oct 18, 2026 - NFL
Sep 27, 2026 - NFL
Sep 13, 2026 - NFL
Dec 28, 2025 - NFL
Dec 22, 2025 - NFL
Nov 30, 2025 - NFL
1/6 (17%)
5/6 (83%)
Nov 1, 2026 - NFL
Oct 25, 2026 - NFL
Oct 11, 2026 - NFL
Oct 4, 2026 - NFL
Sep 20, 2026 - NFL
Jan 4, 2026 - NFL
2/6 (33%)
4/6 (67%)
Nov 1, 2026 - NFL
Oct 26, 2026 - NFL
Oct 18, 2026 - NFL
Oct 8, 2026 - NFL
Oct 4, 2026 - NFL
Sep 27, 2026 - NFL
1/6 (17%)
5/6 (83%)
Nov 1, 2026 - NFL
Oct 8, 2026 - NFL
Sep 27, 2026 - NFL
Sep 20, 2026 - NFL
Dec 21, 2025 - NFL
Dec 14, 2025 - NFL
3/6 (50%)
3/6 (50%)
Oct 26, 2026 - NFL
Oct 18, 2026 - NFL
Oct 4, 2026 - NFL
Sep 13, 2026 - NFL
Jan 4, 2026 - NFL
Dec 25, 2025 - NFL
Indianapolis Colts against Dallas Cowboys : Head to Head (H2H)
0 %
100 %
Dec 4, 2022 - NFL
Indianapolis Colts - Dallas Cowboys Key Points
- The total has gone OVER in 8 of the Cowboys’ last 10 games.
- The Cowboys average 27.4 points per game.
- The Colts average 20.1 points per game.
- The total has gone OVER in 3 of the Colts’ last 4 games.
Limited Offer. Currently at DraftKings
Our Indianapolis Colts vs Dallas Cowboys Prediction
Key Stats: These are the two worst defensive teams in the NFL this season. Dallas often finds itself involved in high-scoring contests, including a 34-30 win over Houston in Week 4 and the recent 30-33 loss to the Cardinals. Colts are decent offensively at home, scoring 20.1 points per game.
Betting Analysis: Pick the Over at 51.5 points. Dallas’ high-octane offense will set the tempo and make this into an entertaining, high-scoring contest. Indiana should bounce back from their 7-point output against Jacksonville by taking advantage of the Cowboys’ porous pass defense.
Parlay Option: A high-value, two-leg parlay could be in play for this matchup. Combining Over 51.5 points with the Cowboys covering 5.5 points raises the payout to a tantalizing +252.
Fearless Forecast: Dallas Cowboys win 36-23
Our betting prediction for the Dallas Cowboys vs. the Indianapolis Colts: Cowboys -5.5 points + Over 51.5 points (2-leg parlay)
Prediction:
The Cowboys -5.5 points + OVER 51.5 points (2-leg parlay)
A Welcome Bonus for Indianapolis Colts vs Dallas Cowboys!

Looking to place a bet on Indianapolis Colts vs Dallas Cowboys? For this NFL match, DraftKings will treat you to an exclusive offer: $200 in bonus bets, no promo code needed! Take advantage while you still can!
All tips are fully researched and given in good faith, but profits cannot be guaranteed.