Los Angeles Rams vs New York Giants Prediction & Picks - NFL

USA - NFL

Los Angeles Rams
9/21/26 20:15
New York Giants

Prediction:

 

New York Giants +7.5 Alternate Spread

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 by Matt Lowrimore | in NFL Picks

Week 2 of the NFL will conclude on Monday night with an NFC matchup between the Los Angeles Rams and the New York Giants. Let’s take a look at the match statistics and predictions for this game between the Rams and the Giants.

New York enters this game with a record of 1-0. The Giants are coming off an impressive win against the Dallas Cowboys in Week 1, beating them by a score of 28-20. Note that this was the first game for head coach John Harbaugh with the Giants. In this game, the Giants were able to gain nearly 400 yards of offense, while holding the Cowboys to under 250 yards. Given their new look, the Giants look likely to once again be competitive in this game, even against the Rams, who are expected to be Super Bowl contenders. 

As for Los Angeles, they enter this game with a record of 0-1. The Rams had one of the most disappointing opening games in Week 1, as they lost to the San Francisco 49ers by a score of 27-7 in Australia. Most notably, the Rams’ offense did not even gain 300 yards and only scored a single touchdown. This alone creates doubt about their ability going forward, especially with some injuries already starting to plague them.

Los Angeles Rams vs New York Giants Form

Table

Teams Pts P W L
8 New York Giants
1 1 1 0
32 Los Angeles Rams
0 1 0 1

Los Angeles Rams and New York Giants Latest Matches

Los Angeles Rams
Los Angeles Rams Latest matches
L W W W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 10, 2026 - NFL

Los Angeles Rams
7 :  27
San Francisco 49ers

Jan 25, 2026 - NFL

Seattle Seahawks
31 :  27
Los Angeles Rams

Jan 18, 2026 - NFL

Chicago Bears
17 :  20
Los Angeles Rams

Jan 10, 2026 - NFL

Carolina Panthers
31 :  34
Los Angeles Rams

Jan 4, 2026 - NFL

Los Angeles Rams
37 :  20
Arizona Cardinals

Dec 29, 2025 - NFL

Atlanta Falcons
27 :  24
Los Angeles Rams
W W W W W L
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 10, 2026 - NFL

Los Angeles Rams
7 :  27
San Francisco 49ers

Jan 4, 2026 - NFL

Los Angeles Rams
37 :  20
Arizona Cardinals

Dec 14, 2025 - NFL

Los Angeles Rams
41 :  34
Detroit Lions

Nov 23, 2025 - NFL

Los Angeles Rams
34 :  7
Tampa Bay Buccaneers

Nov 16, 2025 - NFL

Los Angeles Rams
21 :  19
Seattle Seahawks

Nov 2, 2025 - NFL

Los Angeles Rams
34 :  10
New Orleans Saints
W L L W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Jan 25, 2026 - NFL

Seattle Seahawks
31 :  27
Los Angeles Rams

Jan 18, 2026 - NFL

Chicago Bears
17 :  20
Los Angeles Rams

Jan 10, 2026 - NFL

Carolina Panthers
31 :  34
Los Angeles Rams

Dec 29, 2025 - NFL

Atlanta Falcons
27 :  24
Los Angeles Rams

Dec 18, 2025 - NFL

Seattle Seahawks
38 :  37
Los Angeles Rams

Dec 7, 2025 - NFL

Arizona Cardinals
17 :  45
Los Angeles Rams
New York Giants
New York Giants Latest matches
L L L W W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 13, 2026 - NFL

New York Giants
28 :  20
Dallas Cowboys

Jan 4, 2026 - NFL

New York Giants
34 :  17
Dallas Cowboys

Dec 28, 2025 - NFL

Las Vegas Raiders
10 :  34
New York Giants

Dec 21, 2025 - NFL

New York Giants
13 :  16
Minnesota Vikings

Dec 14, 2025 - NFL

New York Giants
21 :  29
Washington Commanders

Dec 1, 2025 - NFL

New England Patriots
33 :  15
New York Giants
L L L L W W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Sep 13, 2026 - NFL

New York Giants
28 :  20
Dallas Cowboys

Jan 4, 2026 - NFL

New York Giants
34 :  17
Dallas Cowboys

Dec 21, 2025 - NFL

New York Giants
13 :  16
Minnesota Vikings

Dec 14, 2025 - NFL

New York Giants
21 :  29
Washington Commanders

Nov 16, 2025 - NFL

New York Giants
20 :  27
Green Bay Packers

Nov 2, 2025 - NFL

New York Giants
24 :  34
San Francisco 49ers
L L L L L W
Victories

1/6 (17%)

Defeats

5/6 (83%)

Dec 28, 2025 - NFL

Las Vegas Raiders
10 :  34
New York Giants

Dec 1, 2025 - NFL

New England Patriots
33 :  15
New York Giants

Nov 23, 2025 - NFL

Detroit Lions
34 :  27
New York Giants

Nov 9, 2025 - NFL

Chicago Bears
24 :  20
New York Giants

Oct 26, 2025 - NFL

Philadelphia Eagles
38 :  20
New York Giants

Oct 19, 2025 - NFL

Denver Broncos
33 :  32
New York Giants

Los Angeles Rams against New York Giants : Head to Head (H2H)

Los Angeles Rams

100 %

New York Giants

0 %

Dec 31, 2023 - NFL

New York Giants
25 :  26
Los Angeles Rams
Los Angeles Rams vs New York Giants Picks

Los Angeles Rams - New York Giants Key Points

  1. New York scored 28 points in Week 1
  2. New York is 1-0 ATS this season
  3. Los Angeles is 0-1 ATS this season
  4. Los Angeles scored 7 points in Week 1

Our Los Angeles Rams vs New York Giants Prediction

The Rams may be a touchdown favorite in this game; however, the Giants look to be the best betting option. New York has a chance to be an under-the-radar team this season, and if Week 1 is any indication, they are likely going to have a chance to win this game outright. 

The Rams, on the other hand, just put Myles Garrett on the injured reserve list. They will likely have Aaron Donald back for this game, but one of their top wide receivers, Puka Nacua, is listed as questionable.

There is a good chance that the Rams will play at a much higher level compared to Week 1, but given how the Giants looked against the Cowboys, our Los Angeles Rams vs. New York Giants prediction is: New York Giants +7.5 Alternate Spread.

Prediction:

 

New York Giants +7.5 Alternate Spread

-124
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.