Arizona Cardinals vs Seattle Seahawks Prediction & Picks - NFL

USA - NFL

Arizona Cardinals
9/20/26 16:25
Seattle Seahawks

Prediction:

 

Seattle -3.5

-120
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 by Bill Christy | in NFL Picks

Two teams from the NFC West division, which could end up being the most competitive in football, will meet Sunday afternoon in Arizona. The Cardinals will host the defending champion Seattle Seahawks.

Arizona is coming off an impressive performance on the road against the Los Angeles Chargers. They were able to hold Justin Herbert to just over 200 yards passing, sacked him 3 times, and forced 2 turnovers. The connection of Jacoby Brissett and Trey McBride was off to a hot start. They connected on 9 of their 13 passes for 95 yards and a touchdown. Tyler Allgier and Jeremiyah Love combined for 102 yards on the ground and a touchdown.

Seattle began their title defense with a come-from-behind win over their opponents from last year’s Super Bowl. Sam Darnold went down with a game-ending injury, and Drew Lock entered to take over his duties. Trailing 10-0 in the 3rd quarter, Seattle was able to kick a field goal before scoring the tying touchdown early in the 4th quarter. Lock hit Jaxon Smith-Njigba for that touchdown and then led them to a game-winning drive that ended with a Jason Myers field goal. Lock will continue to start for Darnold as he continues to recover from his injury over the next couple of weeks.

Arizona Cardinals vs Seattle Seahawks Form

Table

Teams Pts P W L
11 Arizona Cardinals
1 1 1 0
15 Seattle Seahawks
1 1 1 0

Arizona Cardinals and Seattle Seahawks Latest Matches

Arizona Cardinals
Arizona Cardinals Latest matches
L L L L L W
Victories

1/6 (17%)

Defeats

5/6 (83%)

Sep 13, 2026 - NFL

Los Angeles Chargers
14 :  26
Arizona Cardinals

Jan 4, 2026 - NFL

Los Angeles Rams
37 :  20
Arizona Cardinals

Dec 28, 2025 - NFL

Cincinnati Bengals
37 :  14
Arizona Cardinals

Dec 21, 2025 - NFL

Arizona Cardinals
19 :  26
Atlanta Falcons

Dec 14, 2025 - NFL

Houston Texans
40 :  20
Arizona Cardinals

Dec 7, 2025 - NFL

Arizona Cardinals
17 :  45
Los Angeles Rams
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

Dec 21, 2025 - NFL

Arizona Cardinals
19 :  26
Atlanta Falcons

Dec 7, 2025 - NFL

Arizona Cardinals
17 :  45
Los Angeles Rams

Nov 23, 2025 - NFL

Arizona Cardinals
24 :  27
Jacksonville Jaguars

Nov 16, 2025 - NFL

Arizona Cardinals
22 :  41
San Francisco 49ers

Oct 19, 2025 - NFL

Arizona Cardinals
23 :  27
Green Bay Packers

Oct 5, 2025 - NFL

Arizona Cardinals
21 :  22
Tennessee Titans
L L L L L W
Victories

1/6 (17%)

Defeats

5/6 (83%)

Sep 13, 2026 - NFL

Los Angeles Chargers
14 :  26
Arizona Cardinals

Jan 4, 2026 - NFL

Los Angeles Rams
37 :  20
Arizona Cardinals

Dec 28, 2025 - NFL

Cincinnati Bengals
37 :  14
Arizona Cardinals

Dec 14, 2025 - NFL

Houston Texans
40 :  20
Arizona Cardinals

Nov 30, 2025 - NFL

Tampa Bay Buccaneers
20 :  17
Arizona Cardinals

Nov 9, 2025 - NFL

Seattle Seahawks
44 :  22
Arizona Cardinals
Seattle Seahawks
Seattle Seahawks Latest matches
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Sep 9, 2026 - NFL

Seattle Seahawks
13 :  10
New England Patriots

Feb 8, 2026 - NFL

New England Patriots
13 :  29
Seattle Seahawks

Jan 25, 2026 - NFL

Seattle Seahawks
31 :  27
Los Angeles Rams

Jan 17, 2026 - NFL

Seattle Seahawks
41 :  6
San Francisco 49ers

Jan 3, 2026 - NFL

San Francisco 49ers
3 :  13
Seattle Seahawks

Dec 28, 2025 - NFL

Carolina Panthers
10 :  27
Seattle Seahawks
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Sep 9, 2026 - NFL

Seattle Seahawks
13 :  10
New England Patriots

Jan 25, 2026 - NFL

Seattle Seahawks
31 :  27
Los Angeles Rams

Jan 17, 2026 - NFL

Seattle Seahawks
41 :  6
San Francisco 49ers

Dec 18, 2025 - NFL

Seattle Seahawks
38 :  37
Los Angeles Rams

Dec 14, 2025 - NFL

Seattle Seahawks
18 :  16
Indianapolis Colts

Nov 30, 2025 - NFL

Seattle Seahawks
26 :  0
Minnesota Vikings
L W W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Feb 8, 2026 - NFL

New England Patriots
13 :  29
Seattle Seahawks

Jan 3, 2026 - NFL

San Francisco 49ers
3 :  13
Seattle Seahawks

Dec 28, 2025 - NFL

Carolina Panthers
10 :  27
Seattle Seahawks

Dec 7, 2025 - NFL

Atlanta Falcons
9 :  37
Seattle Seahawks

Nov 23, 2025 - NFL

Tennessee Titans
24 :  30
Seattle Seahawks

Nov 16, 2025 - NFL

Los Angeles Rams
21 :  19
Seattle Seahawks

Arizona Cardinals against Seattle Seahawks : Head to Head (H2H)

Arizona Cardinals

0 %

Seattle Seahawks

100 %

Nov 9, 2025 - NFL

Seattle Seahawks
44 :  22
Arizona Cardinals

Sep 25, 2025 - NFL

Arizona Cardinals
20 :  23
Seattle Seahawks

Dec 8, 2024 - NFL

Arizona Cardinals
18 :  30
Seattle Seahawks

Nov 24, 2024 - NFL

Seattle Seahawks
16 :  6
Arizona Cardinals

Jan 7, 2024 - NFL

Arizona Cardinals
20 :  21
Seattle Seahawks

Nov 6, 2022 - NFL

Arizona Cardinals
21 :  31
Seattle Seahawks
Arizona Cardinals vs Seattle Seahawks Picks

Arizona Cardinals - Seattle Seahawks Key Points

  1. Cardinals are 0-4 ATS in their last 4 meetings.
  2. Seahawks are 5-0 ATS vs. a team with a winning record.
  3. Seahawks are 4-0 ATS in their last 4 vs. NFC.
  4. Seahawks are 4-0 ATS in their last 4 games as a road favorite.

Our Arizona Cardinals vs Seattle Seahawks Prediction

It was a great start for the Cardinals in week one, but now they face the defending champions coming in after an extended break following last Wednesday's game. Lock will now have a full set of practices with the first team, and their defense will be giving Brissett and company fits. We expect Seattle to continue their title defense with another road win.

Our prediction for Arizona Cardinals vs Seattle Seahawks: Seattle -3.5

Prediction:

 

Seattle -3.5

-120
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.