San Francisco 49ers vs Miami Dolphins Prediction & Picks - NFL

Prediction published on 9/18/26, 4:25 PM  by Matt Lowrimore | Modified on 9/18/26 at 4:30 PM in NFL Picks

A 14-game NFL slate is scheduled for Sunday, one of which will feature a matchup between the San Francisco 49ers and the Miami Dolphins. Let’s take a look at the match statistics and predictions for this game between the 49ers and the Dolphins.

Miami enters this game with a record of 0-1. The Dolphins lost to the Las Vegas Raiders in Week 1 by a score of 27-13. Miami was pretty much ineffective offensively, as they mustered just 259 yards of offense, while only scoring one touchdown. That said, the Dolphins allowed less than 300 yards, so their defense did not play awful, suggesting they may be able to keep the 49ers’ offense in check.

As for San Francisco, they enter this game with a record of 1-0. The 49ers are coming off a dominant win against the Los Angeles Rams, beating them by a score of 27-7 in Australia. The 49ers were efficient offensively, with 379 yards of offense, but their defense was even better, holding the Rams to just 7 points and forcing two turnovers. With San Francisco now playing Miami, their defense looks likely to dominate again, which could lead to another low-scoring game.