Kansas City Chiefs vs Indianapolis Colts Prediction & Picks - NFL

Prediction published on 9/18/26, 8:20 PM  by Matt Lowrimore | Modified on 9/18/26 at 8:20 PM in NFL Picks

The Week 2 Sunday NFL slate will conclude with an AFC matchup between the Kansas City Chiefs and the Indianapolis Colts. Let’s take a look at the match statistics for this game between the Chiefs and the Colts.

Indianapolis enters this game with a record of 0-1. The Colts were crushed by the Baltimore Ravens in Week 1, as they lost by a score of 41-23. The biggest issue for the Colts in this game was their defense, as they allowed 506 yards and, more specifically, 202 rushing yards. Further, the Colts allowed four rushing touchdowns, three of which were by Ravens’ running back Derrick Henry.

As for Kansas City, they enter this game with a record of 1-0. The Chiefs dominated the Denver Broncos in Week 1, beating them by a score of 31-10. This was the Chiefs' debut for Kenneth Walker III, and he did not disappoint with 173 rushing yards and two total touchdowns. This was also the return for quarterback Patrick Mahomes, who started slowly but ended up carving up the Broncos’ defense, a trend that looks likely to continue against the Colts.