Chicago Cubs vs San Francisco Giants Prediction & Picks - MLB

USA - MLB

Chicago Cubs
8/28/25 15:45
San Francisco Giants

Prediction:

 

Chicago ML

-126
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 by Travis Pulver in MLB Picks

The Chicago Cubs will try to get back on the right side of the scoreboard today when they face the Giants in the second game of a three-game series at Oracle Park in San Francisco. First Pitch for this NL battle is scheduled for 9:45 pm EST. Chicago came into the series fresh off a sweep of the Angels in LA and having won six of their last seven games. But the lineup struggled against Justin Verlander, scattering seven hits over Verlander's six innings and scoring just two runs en route to a 5-2 loss.

Colin Rea will start for the Cubs today. Rea has gone 10-5 in 22 starts (26 appearances) with a 3.96 ERA, 1.29 WHIP, and .261 OBA. He went 5-2 in eight starts (11 appearances) on the road with a 3.81 ERA and .274 OBA. In a May 6 start vs. the Giants at home, he pitched five innings, giving up eight hits, five runs (four earned), and two walks while striking out four. As for the Giants, young Carson Whisenhunt will get the start, his fifth of the season. He went 1-1 with a 4.91 ERA, 1.42 WHIP, and a .243 OBA. Two of his starts have been at home; he's gone 0-1 with a 7.00 ERA and .270 OBA.

Chicago Cubs vs San Francisco Giants Form

Table

Teams % P W L
4
Chicago Cubs
Chicago Cubs
0.576 132 76 56
18
San Francisco Giants
San Francisco Giants
0.485 132 64 68

Chicago Cubs and San Francisco Giants Latest Matches

Chicago Cubs
Chicago Cubs Latest matches
W L W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Aug 26, 2025 - MLB

Chicago Cubs
2 :  5
San Francisco Giants

Aug 24, 2025 - MLB

Chicago Cubs
4 :  3
Los Angeles Angels

Aug 23, 2025 - MLB

Chicago Cubs
12 :  1
Los Angeles Angels

Aug 22, 2025 - MLB

Chicago Cubs
3 :  2
Los Angeles Angels

Aug 21, 2025 - MLB

Milwaukee Brewers
4 :  1
Chicago Cubs

Aug 20, 2025 - MLB

Milwaukee Brewers
3 :  4
Chicago Cubs
W L W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Aug 21, 2025 - MLB

Milwaukee Brewers
4 :  1
Chicago Cubs

Aug 20, 2025 - MLB

Milwaukee Brewers
3 :  4
Chicago Cubs

Aug 19, 2025 - MLB

Milwaukee Brewers
1 :  4
Chicago Cubs

Aug 19, 2025 - MLB

Milwaukee Brewers
4 :  6
Chicago Cubs

Aug 18, 2025 - MLB

Milwaukee Brewers
7 :  0
Chicago Cubs

Aug 17, 2025 - MLB

Pittsburgh Pirates
3 :  4
Chicago Cubs
W L W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Aug 26, 2025 - MLB

Chicago Cubs
2 :  5
San Francisco Giants

Aug 24, 2025 - MLB

Chicago Cubs
4 :  3
Los Angeles Angels

Aug 23, 2025 - MLB

Chicago Cubs
12 :  1
Los Angeles Angels

Aug 22, 2025 - MLB

Chicago Cubs
3 :  2
Los Angeles Angels

Aug 14, 2025 - MLB

Chicago Cubs
1 :  2
Toronto Blue Jays

Aug 13, 2025 - MLB

Chicago Cubs
4 :  1
Toronto Blue Jays
San Francisco Giants
San Francisco Giants Latest matches
L L W L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Aug 26, 2025 - MLB

Chicago Cubs
2 :  5
San Francisco Giants

Aug 24, 2025 - MLB

San Francisco Giants
4 :  3
Milwaukee Brewers

Aug 23, 2025 - MLB

San Francisco Giants
7 :  1
Milwaukee Brewers

Aug 22, 2025 - MLB

San Francisco Giants
4 :  5
Milwaukee Brewers

Aug 21, 2025 - MLB

San Francisco Giants
4 :  8
San Diego Padres

Aug 20, 2025 - MLB

San Francisco Giants
1 :  8
San Diego Padres
L L L W L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Aug 26, 2025 - MLB

Chicago Cubs
2 :  5
San Francisco Giants

Aug 17, 2025 - MLB

Tampa Bay Rays
1 :  7
San Francisco Giants

Aug 16, 2025 - MLB

Tampa Bay Rays
2 :  1
San Francisco Giants

Aug 15, 2025 - MLB

Tampa Bay Rays
7 :  6
San Francisco Giants

Aug 13, 2025 - MLB

San Diego Padres
11 :  1
San Francisco Giants

Aug 12, 2025 - MLB

San Diego Padres
5 :  1
San Francisco Giants
L L L L W W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Aug 24, 2025 - MLB

San Francisco Giants
4 :  3
Milwaukee Brewers

Aug 23, 2025 - MLB

San Francisco Giants
7 :  1
Milwaukee Brewers

Aug 22, 2025 - MLB

San Francisco Giants
4 :  5
Milwaukee Brewers

Aug 21, 2025 - MLB

San Francisco Giants
4 :  8
San Diego Padres

Aug 20, 2025 - MLB

San Francisco Giants
1 :  8
San Diego Padres

Aug 19, 2025 - MLB

San Francisco Giants
1 :  5
San Diego Padres

Chicago Cubs against San Francisco Giants : Head to Head (H2H)

Chicago Cubs

17 %

San Francisco Giants

83 %

Aug 26, 2025 - MLB

Chicago Cubs
2 :  5
San Francisco Giants

May 7, 2025 - MLB

San Francisco Giants
3 :  1
Chicago Cubs

May 6, 2025 - MLB

San Francisco Giants
14 :  5
Chicago Cubs

May 5, 2025 - MLB

San Francisco Giants
2 :  9
Chicago Cubs

Mar 9, 2025 - MLB Spring Training

San Francisco Giants
8 :  6
Chicago Cubs

Feb 26, 2025 - MLB Spring Training

Chicago Cubs
4 :  4
San Francisco Giants

Chicago Cubs - San Francisco Giants Key Points

  1. San Francisco leads the all-time series 1162-1074-25.
  2. The Giants will likely have a short leash for Whisenhunt; in his four starts, he has gone five, 5 1/3, and four innings (2x).
  3. The Cubs have gone 19-17 since the break with a +4-run differential; the Giants have gone 12-23 (league worst) with a -24 run differential.
  4. Betting Public: 79% of moneyline tickets and 78% of the handle are on the Cubs.

Our Chicago Cubs vs San Francisco Giants Prediction

Chicago has been a solid road team this season and has a habit of bouncing back after losses (39-16 following a loss). They haven't been great at the plate lately (.238 BA over the last week). But they'll benefit from facing a shaky youngster in Whisenhunt. Carlos Rea can handle San Francisco's shaky lineup.

Our Cubs vs. Giants Pick: Chicago ML

Prediction:

 

Chicago ML

-126
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Chicago Cubs vs San Francisco Giants Picks