Chicago White Sox vs Kansas City Royals Prediction & Picks - MLB

Prediction published on 8/27/25, 3:52 PM  by Lou Aguila | Modified on 9/1/25 at 1:03 AM in MLB Picks

The Kansas City Royals have won seven of their last 10 meetings with the Chicago White Sox.

Will the Royals, listed as -132 favorites, maintain their mastery over the worst team in the American League in Wednesday’s series finale?

The Royals evened the series at 1-1 after clawing back from a 0-4 hole to edge the White Sox 5-4 in Game 2. Kansas City trailed the White Sox by four runs after seven innings, but Maikel Garcia and Michael Massey ignited a late rally by coming through with two-run singles each to tie the game at 4-4. Kyle Isbel broke the deadlock with an RBI single at the top of the 9th, while Carlos Estevez earned his 35th save of the season after securing the final three outs of the match. Kansas City improved its record to 68-65, three games within the 71-62 Seattle Mariners, who hold the third and final wild card spot in the American League.

The White Sox own the worst record in the American League at 48-84, though the infamy of having the worst record in the MLB goes to the Colorado Rockies, who hold a 38-94 record. After winning 3 of their last five games, Chicago has bumped up its run production to 7.1 runs per game in the last five games. They have also pitched an impeccable 2.28 ERA and 0.97 WHIP in the said stretch.