San Francisco Giants vs Chicago Cubs Prediction & Picks - MLB

USA - MLB

San Francisco Giants
8/27/25 21:45
Chicago Cubs

Prediction:

 

The Giants will win

+104
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 by Lou Aguila | in MLB Picks

The San Francisco Giants, listed as +104 underdogs, will go for their fourth win in a row against the Chicago Cubs in Wednesday’s Game 2 at Oracle Park.

The Giants carried over the momentum from their back-to-back wins over the Milwaukee Brewers into Tuesday’s series opener against the Cubs. Future Hall of Famer Justin Verlander threw for six innings, surrendering two earned runs and seven hits to earn his first career win since joining the Giants. Third baseman Matt Chapman delivered a two-run blast in the 6th inning to cap a 4-0 run by the Giants in the fifth and sixth innings. The win improved the Giants’ regular-season record to 64-68, third in the NL West behind World Series contenders LA Dodgers (75-57) and the San Diego Padres (74-58).

As for the Cubs, the loss increased the Brewers’ lead on them to 6.5 games with roughly a month left in the regular season. The Cubs, who dominated the Los Angeles Angels in the previous series, are 2-6 in their last eight meetings with the Giants. It would be interesting to see how Chicago will bounce back from this setback in Game 2.

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San Francisco Giants vs Chicago Cubs Form

Table

Teams Pts P W L
6 Chicago Cubs
0.568 162 92 70
16 San Francisco Giants
0.5 162 81 81

San Francisco Giants and Chicago Cubs Latest Matches

San Francisco Giants
San Francisco Giants Latest matches
L L L W W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Aug 26, 2025 - MLB

San Francisco Giants
5 :  2
Chicago Cubs

Aug 24, 2025 - MLB

Milwaukee Brewers
3 :  4
San Francisco Giants

Aug 23, 2025 - MLB

Milwaukee Brewers
1 :  7
San Francisco Giants

Aug 22, 2025 - MLB

Milwaukee Brewers
5 :  4
San Francisco Giants

Aug 21, 2025 - MLB

San Diego Padres
8 :  4
San Francisco Giants

Aug 20, 2025 - MLB

San Diego Padres
8 :  1
San Francisco Giants
L L L L W W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Aug 26, 2025 - MLB

San Francisco Giants
5 :  2
Chicago Cubs

Aug 17, 2025 - MLB

San Francisco Giants
7 :  1
Tampa Bay Rays

Aug 16, 2025 - MLB

San Francisco Giants
1 :  2
Tampa Bay Rays

Aug 15, 2025 - MLB

San Francisco Giants
6 :  7
Tampa Bay Rays

Aug 13, 2025 - MLB

San Francisco Giants
1 :  11
San Diego Padres

Aug 12, 2025 - MLB

San Francisco Giants
1 :  5
San Diego Padres
L L L L W W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Aug 24, 2025 - MLB

Milwaukee Brewers
3 :  4
San Francisco Giants

Aug 23, 2025 - MLB

Milwaukee Brewers
1 :  7
San Francisco Giants

Aug 22, 2025 - MLB

Milwaukee Brewers
5 :  4
San Francisco Giants

Aug 21, 2025 - MLB

San Diego Padres
8 :  4
San Francisco Giants

Aug 20, 2025 - MLB

San Diego Padres
8 :  1
San Francisco Giants

Aug 19, 2025 - MLB

San Diego Padres
5 :  1
San Francisco Giants
Chicago Cubs
Chicago Cubs Latest matches
W L W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Aug 26, 2025 - MLB

San Francisco Giants
5 :  2
Chicago Cubs

Aug 24, 2025 - MLB

Los Angeles Angels
3 :  4
Chicago Cubs

Aug 23, 2025 - MLB

Los Angeles Angels
1 :  12
Chicago Cubs

Aug 22, 2025 - MLB

Los Angeles Angels
2 :  3
Chicago Cubs

Aug 21, 2025 - MLB

Chicago Cubs
1 :  4
Milwaukee Brewers

Aug 20, 2025 - MLB

Chicago Cubs
4 :  3
Milwaukee Brewers
W L W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Aug 21, 2025 - MLB

Chicago Cubs
1 :  4
Milwaukee Brewers

Aug 20, 2025 - MLB

Chicago Cubs
4 :  3
Milwaukee Brewers

Aug 19, 2025 - MLB

Chicago Cubs
4 :  1
Milwaukee Brewers

Aug 19, 2025 - MLB

Chicago Cubs
6 :  4
Milwaukee Brewers

Aug 18, 2025 - MLB

Chicago Cubs
0 :  7
Milwaukee Brewers

Aug 17, 2025 - MLB

Chicago Cubs
4 :  3
Pittsburgh Pirates
W L W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Aug 26, 2025 - MLB

San Francisco Giants
5 :  2
Chicago Cubs

Aug 24, 2025 - MLB

Los Angeles Angels
3 :  4
Chicago Cubs

Aug 23, 2025 - MLB

Los Angeles Angels
1 :  12
Chicago Cubs

Aug 22, 2025 - MLB

Los Angeles Angels
2 :  3
Chicago Cubs

Aug 14, 2025 - MLB

Toronto Blue Jays
2 :  1
Chicago Cubs

Aug 13, 2025 - MLB

Toronto Blue Jays
1 :  4
Chicago Cubs

San Francisco Giants against Chicago Cubs : Head to Head (H2H)

San Francisco Giants

83 %

Chicago Cubs

17 %

Aug 26, 2025 - MLB

San Francisco Giants
5 :  2
Chicago Cubs

May 6, 2025 - MLB

Chicago Cubs
5 :  14
San Francisco Giants

Jun 27, 2024 - MLB

San Francisco Giants
3 :  5
Chicago Cubs

Jun 26, 2024 - MLB

San Francisco Giants
4 :  3
Chicago Cubs

Jun 25, 2024 - MLB

San Francisco Giants
5 :  1
Chicago Cubs

Jun 24, 2024 - MLB

San Francisco Giants
5 :  4
Chicago Cubs

San Francisco Giants - Chicago Cubs Key Points

  1. Chicago Cubs is 1-5 SU in its last 6 games when playing on the road against San Francisco.
  2. Chicago Cubs is 2-6 SU in its last 8 games against San Francisco.
  3. San Francisco is 5-1 SU in its last 6 games when playing at home against Chicago Cubs.
  4. San Francisco is 5-11 SU in its last 16 games.
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Our San Francisco Giants vs Chicago Cubs Prediction

The Giants will beat the Cubs again behind another masterful performance from their pitching staff.

San Francisco is 4-1 in its last 5 games when playing at home against the Chicago Cubs. Moreover, the Giants will be starting a lefty in Game 2. Carson Whisenhunt (1-1, 4,91 ERA) hopes he can neutralize a Cubs offense, which is producing 1.7 runs per game in the last five games against left-handed pitchers. In their last three meetings with the Cubs, San Francisco has averaged 6.3 runs per game and held Chicago to 5.0 runs per game.

The Chicago Cubs are 2-6 in their last 8 games against San Francisco and 1-4 in their last 5 games when playing on the road against the said team. Colin Rea is an excellent pitcher with a 3-2 record and a 3.55 ERA in his last five starts. However, he has lost his last two faceoffs with the Giants, yielding a total of 15 runs over 9.0 innings pitched. Although Rea can put together a strong mound appearance anytime, I just can’t trust him to put up terrific numbers against the team that has given him headaches in the past. Moreover, Rea cannot allow the Giants to take a significant lead into the late innings because their bullpen is only giving up 1.98 ERA in the last five games.

Our betting prediction for the Chicago Cubs vs. the San Francisco Giants: the Giants will win.

Prediction:

 

The Giants will win

+104
$250 offered for betting!

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San Francisco Giants vs Chicago Cubs Picks