Washington Commanders vs Los Angeles Chargers Prediction & Picks - NFL

USA - NFL

Washington Commanders
10/5/25 16:25
Los Angeles Chargers

Prediction:

 

Los Angeles Chargers ML

-155
$200 offered for betting!

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 by Matt Lowrimore in NFL Picks

One of the intriguing games on the Week 5 NFL Sunday slate will see the Los Angeles Chargers take on the Washington Commanders. Let’s take a look at the match statistics and predictions for this game between the Chargers and the Commanders.

Washington enters this game with a record of 2-2, having most recently lost to the Atlanta Falcons in Week 4 by a score of 34-27. The Commanders’ offense had a total of 294 yards, while its defense allowed 435 yards. Backup quarterback Marcus Mariota threw for 156 yards, two touchdowns, and one interception, while running back Chris Rodriguez Jr. led the team in rushing with 59 yards.

As for Los Angeles, they enter this game with a record of 3-1, having most recently lost to the New York Giants in Week 4 by a score of 21-18. The Chargers’ offense had a total of 338 yards, while its defense allowed 250 yards. Quarterback Justin Herbert threw for 203 yards, one touchdown, and two interceptions, while running back Omarion Hampton led the team in rushing with 128 yards and one touchdown.

Washington Commanders vs Los Angeles Chargers Form

Table

Teams % P W D L
6
Los Angeles Chargers
Los Angeles Chargers
0.75 4 3 0 1
17
Washington Commanders
Washington Commanders
0.5 4 2 0 2

Washington Commanders and Los Angeles Chargers Latest Matches

Washington Commanders
Washington Commanders Latest matches
W L W L W L
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Sep 28, 2025 - NFL

Washington Commanders
27 :  34
Atlanta Falcons

Sep 21, 2025 - NFL

Las Vegas Raiders
24 :  41
Washington Commanders

Sep 11, 2025 - NFL

Washington Commanders
18 :  27
Green Bay Packers

Sep 7, 2025 - NFL

New York Giants
6 :  21
Washington Commanders

Jan 26, 2025 - NFL

Washington Commanders
23 :  55
Philadelphia Eagles

Jan 18, 2025 - NFL

Washington Commanders
45 :  31
Detroit Lions
L W W W W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Sep 21, 2025 - NFL

Las Vegas Raiders
24 :  41
Washington Commanders

Sep 7, 2025 - NFL

New York Giants
6 :  21
Washington Commanders

Dec 29, 2024 - NFL

Atlanta Falcons
24 :  30
Washington Commanders

Dec 22, 2024 - NFL

Philadelphia Eagles
33 :  36
Washington Commanders

Dec 1, 2024 - NFL

Tennessee Titans
19 :  42
Washington Commanders

Nov 24, 2024 - NFL

Dallas Cowboys
34 :  26
Washington Commanders
W W W L L L
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Sep 28, 2025 - NFL

Washington Commanders
27 :  34
Atlanta Falcons

Sep 11, 2025 - NFL

Washington Commanders
18 :  27
Green Bay Packers

Jan 26, 2025 - NFL

Washington Commanders
23 :  55
Philadelphia Eagles

Jan 18, 2025 - NFL

Washington Commanders
45 :  31
Detroit Lions

Jan 12, 2025 - NFL

Washington Commanders
23 :  20
Tampa Bay Buccaneers

Jan 5, 2025 - NFL

Washington Commanders
23 :  19
Dallas Cowboys
Los Angeles Chargers
Los Angeles Chargers Latest matches
W L W W W L
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Sep 28, 2025 - NFL

Los Angeles Chargers
18 :  21
New York Giants

Sep 21, 2025 - NFL

Denver Broncos
20 :  23
Los Angeles Chargers

Sep 15, 2025 - NFL

Los Angeles Chargers
20 :  9
Las Vegas Raiders

Sep 5, 2025 - NFL

Kansas City Chiefs
21 :  27
Los Angeles Chargers

Jan 11, 2025 - NFL

Los Angeles Chargers
12 :  32
Houston Texans

Jan 5, 2025 - NFL

Los Angeles Chargers
34 :  20
Las Vegas Raiders
W L L W W W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Sep 21, 2025 - NFL

Denver Broncos
20 :  23
Los Angeles Chargers

Sep 5, 2025 - NFL

Kansas City Chiefs
21 :  27
Los Angeles Chargers

Dec 19, 2024 - NFL

Denver Broncos
27 :  34
Los Angeles Chargers

Dec 15, 2024 - NFL

Tampa Bay Buccaneers
40 :  17
Los Angeles Chargers

Nov 25, 2024 - NFL

Baltimore Ravens
30 :  23
Los Angeles Chargers

Nov 17, 2024 - NFL

Cincinnati Bengals
27 :  34
Los Angeles Chargers
L W W L W L
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Sep 28, 2025 - NFL

Los Angeles Chargers
18 :  21
New York Giants

Sep 15, 2025 - NFL

Los Angeles Chargers
20 :  9
Las Vegas Raiders

Jan 11, 2025 - NFL

Los Angeles Chargers
12 :  32
Houston Texans

Jan 5, 2025 - NFL

Los Angeles Chargers
34 :  20
Las Vegas Raiders

Dec 28, 2024 - NFL

Los Angeles Chargers
40 :  7
New England Patriots

Dec 8, 2024 - NFL

Los Angeles Chargers
17 :  19
Kansas City Chiefs

Washington Commanders - Los Angeles Chargers Key Points

  1. The Chargers are 3-1 ATS this season
  2. The Commanders are 2-2 ATS this season
  3. The Chargers are averaging 22.0 points per game this season
  4. The Commanders are averaging 26.8 points per game this season

Our Washington Commanders vs Los Angeles Chargers Prediction

While the Chargers failed to keep their unbeaten start to the season alive in Week 4, they look to be the better betting option against the Commanders. Especially considering that Washington’s Jayden Daniels is still questionable for this game.

Washington backup quarterback Marcus Mariota lacks the same skill set as Daniels, which was highlighted in the Week 4 loss against the Atlanta Falcons. Further, Los Angeles still has one of the toughest defenses in the NFL and has one of the top quarterbacks in the league with Justin Herbert. 

Given the uncertainty surrounding Daniels, our Los Angeles Chargers vs Washington Commanders prediction is: Los Angeles Chargers ML.

Prediction:

 

Los Angeles Chargers ML

-155
$200 offered for betting!

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Washington Commanders vs Los Angeles Chargers Picks