Arizona Cardinals vs Tennessee Titans Prediction & Picks - NFL

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Arizona Cardinals
10/5/25 16:05
Tennessee Titans

Prediction:

 

Arizona Cardinals -6.5 Alternate Spread

-141
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 by Matt Lowrimore | in NFL Picks

Another one of the games on the Week 5 NFL Sunday slate will see the Arizona Cardinals take on the Tennessee Titans. Let’s take a look at the match statistics and predictions for this game between the Cardinals and the Titans.

Tennessee enters this game with a record of 0-4, having most recently lost to the Houston Texans in Week 4 by a score of 26-0. The Titans’ offense had a total of 175 yards, while its defense allowed 353 yards. Quarterback Cam Ward threw for 108 yards and one interception, while running back Tony Pollard led the team in rushing with 64 yards.

As for Arizona, they enter this game with a record of 2-2, having most recently lost to the Seattle Seahawks in Week 4 by a score of 23-20. The Cardinals’ offense had a total of 253 yards, while its defense allowed 384 yards. Quarterback Kyler Murray threw for 200 yards, two touchdowns, and two interceptions, while also leading the team in rushing with 41 yards.

Arizona Cardinals vs Tennessee Titans Form

Table

Teams Pts P W L
30 Arizona Cardinals
0.176 17 3 14
32 Tennessee Titans
0.176 17 3 14

Arizona Cardinals and Tennessee Titans Latest Matches

Arizona Cardinals
Arizona Cardinals Latest matches
L W W W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 25, 2025 - NFL

Arizona Cardinals
20 :  23
Seattle Seahawks

Sep 21, 2025 - NFL

San Francisco 49ers
16 :  15
Arizona Cardinals

Sep 14, 2025 - NFL

Arizona Cardinals
27 :  22
Carolina Panthers

Sep 7, 2025 - NFL

New Orleans Saints
13 :  20
Arizona Cardinals

Jan 5, 2025 - NFL

Arizona Cardinals
47 :  24
San Francisco 49ers

Dec 28, 2024 - NFL

Los Angeles Rams
13 :  9
Arizona Cardinals
W L W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 25, 2025 - NFL

Arizona Cardinals
20 :  23
Seattle Seahawks

Sep 14, 2025 - NFL

Arizona Cardinals
27 :  22
Carolina Panthers

Jan 5, 2025 - NFL

Arizona Cardinals
47 :  24
San Francisco 49ers

Dec 15, 2024 - NFL

Arizona Cardinals
30 :  17
New England Patriots

Dec 8, 2024 - NFL

Arizona Cardinals
18 :  30
Seattle Seahawks

Nov 10, 2024 - NFL

Arizona Cardinals
31 :  6
New York Jets
L L L L W L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Sep 21, 2025 - NFL

San Francisco 49ers
16 :  15
Arizona Cardinals

Sep 7, 2025 - NFL

New Orleans Saints
13 :  20
Arizona Cardinals

Dec 28, 2024 - NFL

Los Angeles Rams
13 :  9
Arizona Cardinals

Dec 22, 2024 - NFL

Carolina Panthers
36 :  30
Arizona Cardinals

Dec 1, 2024 - NFL

Minnesota Vikings
23 :  22
Arizona Cardinals

Nov 24, 2024 - NFL

Seattle Seahawks
16 :  6
Arizona Cardinals
Tennessee Titans
Tennessee Titans Latest matches
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

Sep 28, 2025 - NFL

Houston Texans
26 :  0
Tennessee Titans

Sep 21, 2025 - NFL

Tennessee Titans
20 :  41
Indianapolis Colts

Sep 14, 2025 - NFL

Tennessee Titans
19 :  33
Los Angeles Rams

Sep 7, 2025 - NFL

Denver Broncos
20 :  12
Tennessee Titans

Jan 5, 2025 - NFL

Tennessee Titans
14 :  23
Houston Texans

Dec 29, 2024 - NFL

Jacksonville Jaguars
20 :  13
Tennessee Titans
L L L L L L
Victories

0/6 (0%)

Defeats

6/6 (100%)

Sep 21, 2025 - NFL

Tennessee Titans
20 :  41
Indianapolis Colts

Sep 14, 2025 - NFL

Tennessee Titans
19 :  33
Los Angeles Rams

Jan 5, 2025 - NFL

Tennessee Titans
14 :  23
Houston Texans

Dec 15, 2024 - NFL

Tennessee Titans
27 :  37
Cincinnati Bengals

Dec 8, 2024 - NFL

Tennessee Titans
6 :  10
Jacksonville Jaguars

Nov 17, 2024 - NFL

Tennessee Titans
13 :  23
Minnesota Vikings
W L L L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Sep 28, 2025 - NFL

Houston Texans
26 :  0
Tennessee Titans

Sep 7, 2025 - NFL

Denver Broncos
20 :  12
Tennessee Titans

Dec 29, 2024 - NFL

Jacksonville Jaguars
20 :  13
Tennessee Titans

Dec 22, 2024 - NFL

Indianapolis Colts
38 :  30
Tennessee Titans

Dec 1, 2024 - NFL

Washington Commanders
42 :  19
Tennessee Titans

Nov 24, 2024 - NFL

Houston Texans
27 :  32
Tennessee Titans

Arizona Cardinals - Tennessee Titans Key Points

  1. The Titans are 0-4 ATS this season
  2. The Cardinals are 1-3 ATS this season
  3. The Titans are averaging 12.8 points per game this season
  4. The Cardinals are averaging 20.5 points per game this season

Our Arizona Cardinals vs Tennessee Titans Prediction

Arizona has certainly not been impressive this season, but they have won a couple of games and has been competitive for the most part. As for Tennessee, they have been dreadful this season, and do not look as if they will improve anytime soon.

The Titans are averaging just 12.8 points per game, by far the fewest in the NFL. Further, the Titans were recently shut out against the Houston Texans in Week 4. The Titans are simply not a team that can be trusted to keep their games close; therefore, our Arizona Cardinals vs Tennessee Titans prediction is: Arizona Cardinals -6.5 Alternate Spread.

Prediction:

 

Arizona Cardinals -6.5 Alternate Spread

-141
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Arizona Cardinals vs Tennessee Titans Picks