USC Trojans vs Oregon Ducks Prediction & Picks - NCAA

USA - NCAA

USC Trojans
11/22/25 15:30
Oregon Ducks

Prediction:

 

USC Trojans +10.5 Alternate Spread

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 by Matt Lowrimore in NCAA Picks

Another one of the games on the Week 13 College Football slate will see the 15th-ranked USC Trojans take on the 7th-ranked Oregon Ducks in the Big Ten. Let’s take a look at the match statistics and predictions for this game between the Trojans and the Ducks.

USC enters this game with a record of 8-2 and 6-1 in the Big Ten. The Trojans most recently beat the Iowa Hawkeyes in Week 12 by a score of 26-21. USC’s offense had a total of 360 yards, while its defense allowed 320 yards. Quarterback Jayden Maiava threw for 254 yards and one touchdown, while running back King Miller led the team in rushing with 83 yards.

As for Oregon, they enter this game with a record of 9-1 and 6-1 in the Big Ten. The Ducks most recently beat the Minnesota Golden Gophers in Week 12 by a score of 42-13. Oregon’s offense had a total of 510 yards, while its defense allowed 200 yards. Quarterback Dante Moore threw for 306 yards and two touchdowns, while running back Noah Whittington led the team in rushing with 72 yards and one touchdown.

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USC Trojans vs Oregon Ducks Form

Table

Teams % P W D L
3
USC Trojans
USC Trojans
0.857 7 6 0 1
5
Oregon Ducks
Oregon Ducks
0.857 7 6 0 1

USC Trojans and Oregon Ducks Latest Matches

USC Trojans
USC Trojans Latest matches
L W L W W W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Nov 15, 2025 - NCAA

Iowa Hawkeyes
21 :  26
USC Trojans

Nov 7, 2025 - NCAA

Northwestern Wildcats
17 :  38
USC Trojans

Nov 1, 2025 - NCAA

USC Trojans
21 :  17
Nebraska Cornhuskers

Oct 18, 2025 - NCAA

USC Trojans
24 :  34
Notre Dame Fighting Irish

Oct 11, 2025 - NCAA

Michigan Wolverines
13 :  31
USC Trojans

Sep 27, 2025 - NCAA

USC Trojans
32 :  34
Illinois Fighting Illini
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Nov 15, 2025 - NCAA

Iowa Hawkeyes
21 :  26
USC Trojans

Nov 7, 2025 - NCAA

Northwestern Wildcats
17 :  38
USC Trojans

Oct 11, 2025 - NCAA

Michigan Wolverines
13 :  31
USC Trojans

Sep 20, 2025 - NCAA

Michigan State Spartans
31 :  45
USC Trojans

Sep 6, 2025 - NCAA

Georgia Southern Eagles
20 :  59
USC Trojans

Aug 30, 2025 - NCAA

Missouri State Bears
13 :  73
USC Trojans
L W W L L W
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Nov 1, 2025 - NCAA

USC Trojans
21 :  17
Nebraska Cornhuskers

Oct 18, 2025 - NCAA

USC Trojans
24 :  34
Notre Dame Fighting Irish

Sep 27, 2025 - NCAA

USC Trojans
32 :  34
Illinois Fighting Illini

Sep 13, 2025 - NCAA

USC Trojans
33 :  17
Purdue Boilermakers

Nov 23, 2024 - NCAA

USC Trojans
19 :  13
UCLA Bruins

Sep 21, 2024 - NCAA

USC Trojans
24 :  27
Michigan Wolverines
Oregon Ducks
Oregon Ducks Latest matches
W L W W W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Nov 14, 2025 - NCAA

Minnesota Golden Gophers
13 :  42
Oregon Ducks

Nov 8, 2025 - NCAA

Oregon Ducks
18 :  16
Iowa Hawkeyes

Oct 25, 2025 - NCAA

Wisconsin Badgers
7 :  21
Oregon Ducks

Oct 18, 2025 - NCAA

Oregon Ducks
56 :  10
Rutgers Scarlet Knights

Oct 11, 2025 - NCAA

Indiana Hoosiers
30 :  20
Oregon Ducks

Sep 27, 2025 - NCAA

Oregon Ducks
30 :  24
Penn State Nittany Lions
W W W L W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Nov 14, 2025 - NCAA

Minnesota Golden Gophers
13 :  42
Oregon Ducks

Oct 25, 2025 - NCAA

Wisconsin Badgers
7 :  21
Oregon Ducks

Oct 11, 2025 - NCAA

Indiana Hoosiers
30 :  20
Oregon Ducks

Sep 20, 2025 - NCAA

Oregon State Beavers
7 :  41
Oregon Ducks

Sep 6, 2025 - NCAA

Oklahoma State Cowboys
3 :  69
Oregon Ducks

Aug 30, 2025 - NCAA

Montana State Bobcats
13 :  59
Oregon Ducks
W W W W W W
Victories

5/5 (100%)

Draw

0/5 (0%)

Defeats

0/5 (0%)

Nov 8, 2025 - NCAA

Oregon Ducks
18 :  16
Iowa Hawkeyes

Oct 18, 2025 - NCAA

Oregon Ducks
56 :  10
Rutgers Scarlet Knights

Sep 27, 2025 - NCAA

Oregon Ducks
30 :  24
Penn State Nittany Lions

Sep 13, 2025 - NCAA

Oregon Ducks
34 :  14
Northwestern Wildcats

Sep 28, 2024 - NCAA

Oregon Ducks
34 :  13
UCLA Bruins

USC Trojans - Oregon Ducks Key Points

  1. USC is 2-5 ATS vs the Big Ten
  2. USC is averaging 32.2 points per game vs the Big Ten
  3. Oregon is 3-4 ATS vs the Big Ten
  4. Oregon is averaging 31.5 points per game vs the Big Ten
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Our USC Trojans vs Oregon Ducks Prediction

Oregon is nearly a double-digit favorite in this game; however, USC could be the best betting option. The Trojans have not fared well against the spread in conference games this season, going just 2-5 in seven games. That being said, USC has mostly been a favorite and has not been a near double-digit underdog much this season. USC is averaging 32.2 points per game against Big Ten opponents as well, meaning they have the chance to put up another big number.

Oregon, on the other hand, has also not been good against the spread in conference games, going 3-4. The Ducks are averaging 31.5 points per game against Big Ten opponents, which suggests that this game could be closer than what the spread suggests. Given that USC has been able to score consistently, our USC Trojans vs Oregon Ducks prediction is: USC Trojans +10.5 Alternate Spread.

Prediction:

 

USC Trojans +10.5 Alternate Spread

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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

USC Trojans vs Oregon Ducks Picks