SMU Mustangs vs Louisville Cardinals Prediction & Picks - NCAA
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by Matt Lowrimore | in NCAA Picks
One of the more intriguing games on the Week 13 College Football slate will see the Louisville Cardinals take on the SMU Mustangs in the ACC. Let’s take a look at the match statistics and predictions for this game between the Cardinals and the Mustangs.
Louisville enters this game with a record of 7-3 and 4-3 in the ACC. The Cardinals most recently lost to the Clemson Tigers in Week 12 by a score of 20-19. Louisville’s offense had a total of 385 yards, while its defense allowed 308 yards. Quarterback Miller Moss threw for 212 yards, while running back Keyjuan Brown led the team in rushing with 135 yards.
As for SMU, they enter this game with a record of 7-3 and 5-1 in the ACC. The Mustangs most recently beat the Boston College Eagles in Week 11 by a score of 45-13. SMU’s offense had a total of 574 yards, while its defense allowed 390 yards. Quarterback Kevin Jennings threw for 326 yards, three touchdowns, and one interception, while running back T.J. Harden led the team in rushing with 130 yards.
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SMU Mustangs vs Louisville Cardinals Form
Table
SMU Mustangs and Louisville Cardinals Latest Matches
5/6 (83%)
1/6 (17%)
Nov 8, 2025 - NCAA
Nov 1, 2025 - NCAA
Oct 25, 2025 - NCAA
Oct 18, 2025 - NCAA
Oct 11, 2025 - NCAA
Oct 4, 2025 - NCAA
4/6 (67%)
2/6 (33%)
Nov 1, 2025 - NCAA
Oct 11, 2025 - NCAA
Oct 4, 2025 - NCAA
Sep 6, 2025 - NCAA
Aug 30, 2025 - NCAA
Sep 6, 2024 - NCAA
3/6 (50%)
3/6 (50%)
Nov 8, 2025 - NCAA
Oct 25, 2025 - NCAA
Oct 18, 2025 - NCAA
Sep 20, 2025 - NCAA
Sep 13, 2025 - NCAA
Dec 21, 2024 - NCAA
3/6 (50%)
3/6 (50%)
Nov 14, 2025 - NCAA
Nov 8, 2025 - NCAA
Nov 1, 2025 - NCAA
Oct 25, 2025 - NCAA
Oct 17, 2025 - NCAA
Oct 4, 2025 - NCAA
3/6 (50%)
3/6 (50%)
Nov 14, 2025 - NCAA
Nov 8, 2025 - NCAA
Oct 25, 2025 - NCAA
Oct 4, 2025 - NCAA
Sep 20, 2025 - NCAA
Sep 5, 2025 - NCAA
3/4 (75%)
1/4 (25%)
Nov 1, 2025 - NCAA
Oct 17, 2025 - NCAA
Sep 27, 2025 - NCAA
Sep 28, 2024 - NCAA
SMU Mustangs - Louisville Cardinals Key Points
- Louisville is 3-4 ATS vs the ACC
- Louisville is averaging 28.4 points per game vs the ACC
- SMU is 4-2 ATS vs the ACC
- SMU is averaging 30.5 points per game vs the ACC
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Our SMU Mustangs vs Louisville Cardinals Prediction
SMU is a small favorite in this game, but still looks to be the best betting option. The Mustangs have just one conference loss this season, a one-point loss to Wake Forest. That being said, they still have the opportunity to control their destiny in the ACC, and if they can win out, they will have a chance to play in the ACC Championship.
Louisville, on the other hand, once looked like a team that could play in the ACC Championship, but has since lost their last two games in a row. Losses to California and Clemson have seriously derailed their season, so with SMU playing much better at this point in time, our Louisville Cardinals vs SMU Mustangs prediction is: SMU Mustangs ML.All tips are fully researched and given in good faith, but profits cannot be guaranteed.
