Oklahoma Sooners vs Missouri Tigers Prediction & Picks - NCAA

USA - NCAA

Oklahoma Sooners
11/22/25 12:00
Missouri Tigers

Prediction:

 

Missouri Tigers +7.5

-112
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 by Matt Lowrimore | in NCAA Picks

The Week 13 College Football slate features a ton of interesting games, including one that will see the 22nd-ranked Missouri Tigers take on the 8th-ranked Oklahoma Sooners in the SEC. Let’s take a look at the match statistics and predictions for this game between the Tigers and the Sooners.

Missouri enters this game with a record of 7-3 and 3-3 in the SEC. The Tigers most recently beat the Mississippi State Bulldogs in Week 12 by a score of 49-27. Missouri’s offense had a total of 438 yards, while its defense allowed 345 yards. Quarterback Matt Zollers threw for 112 yards, two touchdowns, and one interception, while running back Ahmad Hardy led the team in rushing with 300 yards and three touchdowns.

As for Oklahoma, they enter this game with a record of 8-2 and 4-2 in the SEC. The Sooners most recently beat the Alabama Crimson Tide in Week 12 by a score of 23-21. Oklahoma’s offense had a total of 212 yards, while its defense allowed 406 yards. Quarterback John Mateer threw for 138 yards, while running back Xavier Robinson led the team in rushing with 34 yards.

Oklahoma Sooners vs Missouri Tigers Form

Table

Oklahoma Sooners and Missouri Tigers Latest Matches

Oklahoma Sooners
Oklahoma Sooners Latest matches
W L W L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Nov 15, 2025 - NCAA

Alabama Crimson Tide
21 :  23
Oklahoma Sooners

Nov 1, 2025 - NCAA

Tennessee Volunteers
27 :  33
Oklahoma Sooners

Oct 25, 2025 - NCAA

Oklahoma Sooners
26 :  34
Ole Miss Rebels

Oct 18, 2025 - NCAA

South Carolina Gamecocks
7 :  26
Oklahoma Sooners

Oct 11, 2025 - NCAA

Texas Longhorns
23 :  6
Oklahoma Sooners

Oct 4, 2025 - NCAA

Oklahoma Sooners
44 :  0
Kent State Golden Flashes
L W W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Oct 25, 2025 - NCAA

Oklahoma Sooners
26 :  34
Ole Miss Rebels

Oct 4, 2025 - NCAA

Oklahoma Sooners
44 :  0
Kent State Golden Flashes

Sep 20, 2025 - NCAA

Oklahoma Sooners
24 :  17
Auburn Tigers

Sep 6, 2025 - NCAA

Oklahoma Sooners
24 :  13
Michigan Wolverines

Aug 30, 2025 - NCAA

Oklahoma Sooners
35 :  3
Illinois State Redbirds

Oct 19, 2024 - NCAA

Oklahoma Sooners
9 :  35
South Carolina Gamecocks
W L W W W
Victories

4/5 (80%)

Defeats

1/5 (20%)

Nov 15, 2025 - NCAA

Alabama Crimson Tide
21 :  23
Oklahoma Sooners

Nov 1, 2025 - NCAA

Tennessee Volunteers
27 :  33
Oklahoma Sooners

Oct 18, 2025 - NCAA

South Carolina Gamecocks
7 :  26
Oklahoma Sooners

Oct 11, 2025 - NCAA

Texas Longhorns
23 :  6
Oklahoma Sooners

Sep 13, 2025 - NCAA

Temple Owls
3 :  42
Oklahoma Sooners
Missouri Tigers
Missouri Tigers Latest matches
W L W L L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Nov 15, 2025 - NCAA

Missouri Tigers
49 :  27
Mississippi State Bulldogs

Nov 8, 2025 - NCAA

Missouri Tigers
17 :  38
Texas AM Aggies

Oct 25, 2025 - NCAA

Vanderbilt Commodores
17 :  10
Missouri Tigers

Oct 18, 2025 - NCAA

Auburn Tigers
17 :  23
Missouri Tigers

Oct 11, 2025 - NCAA

Missouri Tigers
24 :  27
Alabama Crimson Tide

Sep 27, 2025 - NCAA

Missouri Tigers
42 :  6
UMASS Minutemen
W W W L L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Nov 15, 2025 - NCAA

Missouri Tigers
49 :  27
Mississippi State Bulldogs

Nov 8, 2025 - NCAA

Missouri Tigers
17 :  38
Texas AM Aggies

Oct 11, 2025 - NCAA

Missouri Tigers
24 :  27
Alabama Crimson Tide

Sep 27, 2025 - NCAA

Missouri Tigers
42 :  6
UMASS Minutemen

Sep 20, 2025 - NCAA

Missouri Tigers
29 :  20
South Carolina Gamecocks

Sep 13, 2025 - NCAA

Missouri Tigers
52 :  10
Louisiana Ragin Cajuns
L W L
Victories

1/3 (33%)

Defeats

2/3 (67%)

Oct 25, 2025 - NCAA

Vanderbilt Commodores
17 :  10
Missouri Tigers

Oct 18, 2025 - NCAA

Auburn Tigers
17 :  23
Missouri Tigers

Oct 5, 2024 - NCAA

Texas AM Aggies
41 :  10
Missouri Tigers

Oklahoma Sooners - Missouri Tigers Key Points

  1. Missouri is 3-3 ATS vs the SEC
  2. Missouri is averaging 25.3 points per game vs the SEC
  3. Oklahoma is 4-2 ATS vs the SEC
  4. Oklahoma is averaging 23.0 points per game vs the SEC

Our Oklahoma Sooners vs Missouri Tigers Prediction

Oklahoma is just over a touchdown favorite, and even though they just beat Alabama, their offense has not been the most consistent, especially against conference opponents. The Sooners are averaging just 23.0 points per game against SEC opponents in six conference games.

As for Missouri, their starting quarterback, Beau Pribula, is still dealing with an injury; however, there is some hope that he will be back under center against the Sooners. Overall, the Tigers are averaging 25.3 points per game against SEC opponents.

Even though Oklahoma’s defense has been a big reason for their success, their offense is a bit too inconsistent to trust. For that reason, our Missouri Tigers vs Oklahoma Sooners prediction is: Missouri Tigers +7.5.

Prediction:

 

Missouri Tigers +7.5

-112
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Oklahoma Sooners vs Missouri Tigers Picks