Houston Texans vs Buffalo Bills Prediction & Picks - NFL

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Houston Texans
11/20/25 20:15
Buffalo Bills

Prediction:

 

UNDER 43.5

-105
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 by Travis Pulver | in NFL Picks

The Houston Texans will try to push their record above .500 for the first time this season when they host the Buffalo Bills at NRG Stadium on Thursday Night Football. Kickoff for this AFC battle is scheduled for 8:15 p.m. EST on Prime Video.

Houston enters this game on a two-game winning streak, having won three of its last four games. Thursday will be the third start for backup Davis Mills, filling in for C.J. Stroud, who had to leave the loss to Denver a few weeks ago early because of a concussion. Before Stroud’s concussion, the defense (which happens to be the No. 1 unit in the league) led the way for the Texans, making it possible to win a few games while struggling to get the offense on track.

Josh Allen and the Bills snapped back last week following an embarrassing loss to the Dolphins the week before with a 44-32 win over Tampa Bay. Allen led the way with 317 yards passing and three touchdowns, along with a pair of interceptions. He also added three scores on the ground. But the Bucs defense did shut down James Cook, allowing just 40 rushing yards.

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Houston Texans vs Buffalo Bills Form

Table

Teams Pts P W L
6 Houston Texans
0.706 17 12 5
8 Buffalo Bills
0.706 17 12 5

Houston Texans and Buffalo Bills Latest Matches

Houston Texans
Houston Texans Latest matches
W L W L W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Nov 16, 2025 - NFL

Tennessee Titans
13 :  16
Houston Texans

Nov 9, 2025 - NFL

Houston Texans
36 :  29
Jacksonville Jaguars

Nov 2, 2025 - NFL

Houston Texans
15 :  18
Denver Broncos

Oct 26, 2025 - NFL

Houston Texans
26 :  15
San Francisco 49ers

Oct 20, 2025 - NFL

Seattle Seahawks
27 :  19
Houston Texans

Oct 5, 2025 - NFL

Baltimore Ravens
10 :  44
Houston Texans
W L W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Nov 9, 2025 - NFL

Houston Texans
36 :  29
Jacksonville Jaguars

Nov 2, 2025 - NFL

Houston Texans
15 :  18
Denver Broncos

Oct 26, 2025 - NFL

Houston Texans
26 :  15
San Francisco 49ers

Sep 28, 2025 - NFL

Houston Texans
26 :  0
Tennessee Titans

Sep 15, 2025 - NFL

Houston Texans
19 :  20
Tampa Bay Buccaneers

Jan 11, 2025 - NFL

Houston Texans
32 :  12
Los Angeles Chargers
L L L W L W
Victories

2/6 (33%)

Defeats

4/6 (67%)

Nov 16, 2025 - NFL

Tennessee Titans
13 :  16
Houston Texans

Oct 20, 2025 - NFL

Seattle Seahawks
27 :  19
Houston Texans

Oct 5, 2025 - NFL

Baltimore Ravens
10 :  44
Houston Texans

Sep 21, 2025 - NFL

Jacksonville Jaguars
17 :  10
Houston Texans

Sep 7, 2025 - NFL

Los Angeles Rams
14 :  9
Houston Texans

Jan 18, 2025 - NFL

Kansas City Chiefs
23 :  14
Houston Texans
Buffalo Bills
Buffalo Bills Latest matches
L L W W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Nov 16, 2025 - NFL

Buffalo Bills
44 :  32
Tampa Bay Buccaneers

Nov 9, 2025 - NFL

Miami Dolphins
30 :  13
Buffalo Bills

Nov 2, 2025 - NFL

Buffalo Bills
28 :  21
Kansas City Chiefs

Oct 26, 2025 - NFL

Carolina Panthers
9 :  40
Buffalo Bills

Oct 13, 2025 - NFL

Atlanta Falcons
24 :  14
Buffalo Bills

Oct 5, 2025 - NFL

Buffalo Bills
20 :  23
New England Patriots
W W W L W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Nov 16, 2025 - NFL

Buffalo Bills
44 :  32
Tampa Bay Buccaneers

Nov 2, 2025 - NFL

Buffalo Bills
28 :  21
Kansas City Chiefs

Oct 5, 2025 - NFL

Buffalo Bills
20 :  23
New England Patriots

Sep 28, 2025 - NFL

Buffalo Bills
31 :  19
New Orleans Saints

Sep 18, 2025 - NFL

Buffalo Bills
31 :  21
Miami Dolphins

Sep 7, 2025 - NFL

Buffalo Bills
41 :  40
Baltimore Ravens
L L W L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Nov 9, 2025 - NFL

Miami Dolphins
30 :  13
Buffalo Bills

Oct 26, 2025 - NFL

Carolina Panthers
9 :  40
Buffalo Bills

Oct 13, 2025 - NFL

Atlanta Falcons
24 :  14
Buffalo Bills

Sep 14, 2025 - NFL

New York Jets
10 :  30
Buffalo Bills

Jan 26, 2025 - NFL

Kansas City Chiefs
32 :  29
Buffalo Bills

Jan 5, 2025 - NFL

New England Patriots
23 :  16
Buffalo Bills

Houston Texans against Buffalo Bills : Head to Head (H2H)

Houston Texans

100 %

Buffalo Bills

0 %

Oct 6, 2024 - NFL

Houston Texans
23 :  20
Buffalo Bills

Houston Texans - Buffalo Bills Key Points

  1. Houston holds the all-time series lead vs. Buffalo, 7-5; the Texans won last year’s meeting, 23-20.
  2. Buffalo has lost the last five meetings in Houston; the last time Buffalo won a road game against the Texans was in the 2006 season.
  3. The OVER is 3-6-1 for Houston and 5-5 for Buffalo. The OVER is 1-3 for Buffalo on the road.
  4. Betting Public: 50% of TOTAL tickets and 67% of the handle are on the UNDER.
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Our Houston Texans vs Buffalo Bills Prediction

With how poorly Houston has played on offense for much of the season, it is hard to imagine them actually beating an offensive powerhouse like Buffalo—but they could. If the defense can keep Josh Allen in check and James Cook from heating up, maybe Davis Mills will have enough time to get the offense on track and score enough points to win. But whether they win or not, one outcome seems likely: a low score.

Our Bills vs. Texans Pick: UNDER 43.5

Prediction:

 

UNDER 43.5

-105
$200 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Houston Texans vs Buffalo Bills Picks