Oregon Ducks vs USC Trojans Prediction & Picks - NCAA

USA - NCAA

Oregon Ducks
11/22/25 15:30
USC Trojans

Prediction:

 

USC Trojans +10.5 Alternate Spread

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 by Matt Lowrimore | in NCAA Picks

Another one of the games on the Week 13 College Football slate will see the 15th-ranked USC Trojans take on the 7th-ranked Oregon Ducks in the Big Ten. Let’s take a look at the match statistics and predictions for this game between the Trojans and the Ducks.

USC enters this game with a record of 8-2 and 6-1 in the Big Ten. The Trojans most recently beat the Iowa Hawkeyes in Week 12 by a score of 26-21. USC’s offense had a total of 360 yards, while its defense allowed 320 yards. Quarterback Jayden Maiava threw for 254 yards and one touchdown, while running back King Miller led the team in rushing with 83 yards.

As for Oregon, they enter this game with a record of 9-1 and 6-1 in the Big Ten. The Ducks most recently beat the Minnesota Golden Gophers in Week 12 by a score of 42-13. Oregon’s offense had a total of 510 yards, while its defense allowed 200 yards. Quarterback Dante Moore threw for 306 yards and two touchdowns, while running back Noah Whittington led the team in rushing with 72 yards and one touchdown.

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Oregon Ducks vs USC Trojans Form

Table

Oregon Ducks and USC Trojans Latest Matches

Oregon Ducks
Oregon Ducks Latest matches
W L W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Nov 14, 2025 - NCAA

Oregon Ducks
42 :  13
Minnesota Golden Gophers

Nov 8, 2025 - NCAA

Iowa Hawkeyes
16 :  18
Oregon Ducks

Oct 25, 2025 - NCAA

Oregon Ducks
21 :  7
Wisconsin Badgers

Oct 18, 2025 - NCAA

Rutgers Scarlet Knights
10 :  56
Oregon Ducks

Oct 11, 2025 - NCAA

Oregon Ducks
20 :  30
Indiana Hoosiers

Sep 27, 2025 - NCAA

Penn State Nittany Lions
24 :  30
Oregon Ducks
W W W L W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Nov 14, 2025 - NCAA

Oregon Ducks
42 :  13
Minnesota Golden Gophers

Oct 25, 2025 - NCAA

Oregon Ducks
21 :  7
Wisconsin Badgers

Oct 11, 2025 - NCAA

Oregon Ducks
20 :  30
Indiana Hoosiers

Sep 20, 2025 - NCAA

Oregon Ducks
41 :  7
Oregon State Beavers

Sep 6, 2025 - NCAA

Oregon Ducks
69 :  3
Oklahoma State Cowboys

Aug 30, 2025 - NCAA

Oregon Ducks
59 :  13
Montana State Bobcats
W W W W W
Victories

5/5 (100%)

Defeats

0/5 (0%)

Nov 8, 2025 - NCAA

Iowa Hawkeyes
16 :  18
Oregon Ducks

Oct 18, 2025 - NCAA

Rutgers Scarlet Knights
10 :  56
Oregon Ducks

Sep 27, 2025 - NCAA

Penn State Nittany Lions
24 :  30
Oregon Ducks

Sep 13, 2025 - NCAA

Northwestern Wildcats
14 :  34
Oregon Ducks

Sep 28, 2024 - NCAA

UCLA Bruins
13 :  34
Oregon Ducks
USC Trojans
USC Trojans Latest matches
L W L W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Nov 15, 2025 - NCAA

USC Trojans
26 :  21
Iowa Hawkeyes

Nov 7, 2025 - NCAA

USC Trojans
38 :  17
Northwestern Wildcats

Nov 1, 2025 - NCAA

Nebraska Cornhuskers
17 :  21
USC Trojans

Oct 18, 2025 - NCAA

Notre Dame Fighting Irish
34 :  24
USC Trojans

Oct 11, 2025 - NCAA

USC Trojans
31 :  13
Michigan Wolverines

Sep 27, 2025 - NCAA

Illinois Fighting Illini
34 :  32
USC Trojans
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Nov 15, 2025 - NCAA

USC Trojans
26 :  21
Iowa Hawkeyes

Nov 7, 2025 - NCAA

USC Trojans
38 :  17
Northwestern Wildcats

Oct 11, 2025 - NCAA

USC Trojans
31 :  13
Michigan Wolverines

Sep 20, 2025 - NCAA

USC Trojans
45 :  31
Michigan State Spartans

Sep 6, 2025 - NCAA

USC Trojans
59 :  20
Georgia Southern Eagles

Aug 30, 2025 - NCAA

USC Trojans
73 :  13
Missouri State Bears
L W L L W
Victories

2/5 (40%)

Defeats

3/5 (60%)

Nov 1, 2025 - NCAA

Nebraska Cornhuskers
17 :  21
USC Trojans

Oct 18, 2025 - NCAA

Notre Dame Fighting Irish
34 :  24
USC Trojans

Sep 27, 2025 - NCAA

Illinois Fighting Illini
34 :  32
USC Trojans

Sep 13, 2025 - NCAA

Purdue Boilermakers
17 :  33
USC Trojans

Sep 21, 2024 - NCAA

Michigan Wolverines
27 :  24
USC Trojans

Oregon Ducks - USC Trojans Key Points

  1. USC is 2-5 ATS vs the Big Ten
  2. USC is averaging 32.2 points per game vs the Big Ten
  3. Oregon is 3-4 ATS vs the Big Ten
  4. Oregon is averaging 31.5 points per game vs the Big Ten
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Our Oregon Ducks vs USC Trojans Prediction

Oregon is nearly a double-digit favorite in this game; however, USC could be the best betting option. The Trojans have not fared well against the spread in conference games this season, going just 2-5 in seven games. That being said, USC has mostly been a favorite and has not been a near double-digit underdog much this season. USC is averaging 32.2 points per game against Big Ten opponents as well, meaning they have the chance to put up another big number.

Oregon, on the other hand, has also not been good against the spread in conference games, going 3-4. The Ducks are averaging 31.5 points per game against Big Ten opponents, which suggests that this game could be closer than what the spread suggests. Given that USC has been able to score consistently, our USC Trojans vs Oregon Ducks prediction is: USC Trojans +10.5 Alternate Spread.

Prediction:

 

USC Trojans +10.5 Alternate Spread

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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Oregon Ducks vs USC Trojans Picks