Vanderbilt Commodores vs Kentucky Wildcats Prediction & Picks - NCAA

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Vanderbilt Commodores
11/22/25 15:30
Kentucky Wildcats

Prediction:

 

Kentucky +9.5

-105
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 by Travis Pulver | in NCAA Picks

The No. 14 Vanderbilt Commodores will try to keep their CFP hopes alive when they host the Kentucky Wildcats Saturday afternoon at FirstBank Stadium in Nashville, TN. Kickoff for this important SEC clash is scheduled for 3:30 p.m. EST on ESPN.

After a disappointing loss to Texas a couple of weeks ago, the Commodores bounced back last week with a solid 45-38 win over Auburn. Diego Pavia was up to his usual tricks, throwing for 377 yards and three touchdowns while adding another 112 yards and a score on the ground. He’ll have his work cut out for him against a Kentucky defense that has been playing better lately than their stats would indicate. For the Wildcats, it’s really been a tale of two seasons as they started conference play with four losses but have bounced back with three straight wins (including two SEC victories). The secret? Kentucky has been playing solid defense and running the ball really well. It will not be easy against Vany’s 24th-ranked run defense, but if they can establish the run, they’ll have a real shot at an upset

The stakes are certainly higher for Vanderbilt in this game, but Kentucky needs a win to become bowl-eligible.

Vanderbilt Commodores vs Kentucky Wildcats Form

Table

Vanderbilt Commodores and Kentucky Wildcats Latest Matches

Vanderbilt Commodores
Vanderbilt Commodores Latest matches
W L W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Nov 8, 2025 - NCAA

Vanderbilt Commodores
45 :  38
Auburn Tigers

Nov 1, 2025 - NCAA

Texas Longhorns
34 :  31
Vanderbilt Commodores

Oct 25, 2025 - NCAA

Vanderbilt Commodores
17 :  10
Missouri Tigers

Oct 18, 2025 - NCAA

Vanderbilt Commodores
31 :  24
LSU Tigers

Oct 4, 2025 - NCAA

Alabama Crimson Tide
30 :  14
Vanderbilt Commodores

Sep 27, 2025 - NCAA

Vanderbilt Commodores
55 :  35
Utah State Aggies
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Nov 8, 2025 - NCAA

Vanderbilt Commodores
45 :  38
Auburn Tigers

Oct 25, 2025 - NCAA

Vanderbilt Commodores
17 :  10
Missouri Tigers

Oct 18, 2025 - NCAA

Vanderbilt Commodores
31 :  24
LSU Tigers

Sep 27, 2025 - NCAA

Vanderbilt Commodores
55 :  35
Utah State Aggies

Sep 20, 2025 - NCAA

Vanderbilt Commodores
70 :  21
Georgia State Panthers

Aug 30, 2025 - NCAA

Vanderbilt Commodores
45 :  3
Charleston Southern Buccaneers
L W W L L
Victories

2/5 (40%)

Defeats

3/5 (60%)

Nov 1, 2025 - NCAA

Texas Longhorns
34 :  31
Vanderbilt Commodores

Oct 4, 2025 - NCAA

Alabama Crimson Tide
30 :  14
Vanderbilt Commodores

Sep 13, 2025 - NCAA

South Carolina Gamecocks
7 :  31
Vanderbilt Commodores

Sep 6, 2025 - NCAA

Virginia Tech Hokies
20 :  44
Vanderbilt Commodores

Sep 21, 2024 - NCAA

Missouri Tigers
30 :  27
Vanderbilt Commodores
Kentucky Wildcats
Kentucky Wildcats Latest matches
L L L W W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Nov 15, 2025 - NCAA

Kentucky Wildcats
42 :  10
Tennessee Tech Golden Eagles

Nov 8, 2025 - NCAA

Kentucky Wildcats
38 :  7
Florida Gators

Nov 1, 2025 - NCAA

Auburn Tigers
3 :  10
Kentucky Wildcats

Oct 25, 2025 - NCAA

Kentucky Wildcats
34 :  56
Tennessee Volunteers

Oct 18, 2025 - NCAA

Kentucky Wildcats
13 :  16
Texas Longhorns

Oct 4, 2025 - NCAA

Georgia Bulldogs
35 :  14
Kentucky Wildcats
L W L L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Nov 15, 2025 - NCAA

Kentucky Wildcats
42 :  10
Tennessee Tech Golden Eagles

Nov 8, 2025 - NCAA

Kentucky Wildcats
38 :  7
Florida Gators

Oct 25, 2025 - NCAA

Kentucky Wildcats
34 :  56
Tennessee Volunteers

Oct 18, 2025 - NCAA

Kentucky Wildcats
13 :  16
Texas Longhorns

Sep 13, 2025 - NCAA

Kentucky Wildcats
48 :  23
Eastern Michigan Eagles

Sep 6, 2025 - NCAA

Kentucky Wildcats
23 :  30
Ole Miss Rebels
W L L W
Victories

2/4 (50%)

Defeats

2/4 (50%)

Nov 1, 2025 - NCAA

Auburn Tigers
3 :  10
Kentucky Wildcats

Oct 4, 2025 - NCAA

Georgia Bulldogs
35 :  14
Kentucky Wildcats

Sep 27, 2025 - NCAA

South Carolina Gamecocks
35 :  13
Kentucky Wildcats

Sep 28, 2024 - NCAA

Ole Miss Rebels
17 :  20
Kentucky Wildcats

Vanderbilt Commodores - Kentucky Wildcats Key Points

  1. Kentucky leads the all-time series vs. Vanderbilt, 48-44-4, but Vanderbilt has won two of the last three.
  2. Vanderbilt is 7-2-1 ATS this season while Kentucky is 5-5.
  3. The OVER is 7-3 for both teams this season.
  4. Betting Public: 35% of spread tickets and 40% of the handle are on Kentucky.

Our Vanderbilt Commodores vs Kentucky Wildcats Prediction

Matchups like this can be confusing: do you go with the team that has played better all season long or the hot hand? Vanderbilt is definitely the better of the two teams this season, but the Wildcats are on a roll with three wins in a row. Kentucky’s run game has been getting the job done, and the defense has been stingy. As great as Vanderbilt has been, three of their four SEC wins were by a touchdown.

Our Kentucky vs. Tennessee Pick: Kentucky +9.5

Prediction:

 

Kentucky +9.5

-105
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Vanderbilt Commodores vs Kentucky Wildcats Picks