Louisville Cardinals vs SMU Mustangs Prediction & Picks - NCAA
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by Matt Lowrimore | in NCAA Picks
Week 3 of the College Football season will continue on Saturday with a matchup between the SMU Mustangs and the Louisville Cardinals. Let’s take a look at the match statistics and predictions for this game between the Mustangs and the Cardinals.
SMU enters this game with a record of 2-0 and is ranked #16 in the top-25 poll. Further, the Mustangs are 1-0 in the ACC. SMU is coming off a win in Week 2 against UC Davis, beating them 56-10. It was a completely dominant performance, as they gained 547 yards on offense while allowing just 147 yards. SMU has already shown they can win on the road when they beat Florida State in a tight Week 1 matchup, suggesting they will have similar success against Louisville, who has already shown some cracks.
As for Louisville, they enter this game with a record of 1-1 and are ranked #23 in the top-25 poll. Further, the Cardinals will be playing their first ACC game of the season. Louisville is coming off a win against Villanova in Week 2, as they beat them by a score of 59-10. This followed a gutsy effort against Ole Miss to open the season, in which they lost 41-38.
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Louisville Cardinals vs SMU Mustangs Form
Table
Louisville Cardinals and SMU Mustangs Latest Matches
3/6 (50%)
3/6 (50%)
Sep 11, 2026 - NCAA
Sep 6, 2026 - NCAA
Dec 23, 2025 - NCAA Division I, FBS, Playoffs
Nov 29, 2025 - NCAA
Nov 22, 2025 - NCAA
Nov 14, 2025 - NCAA
4/6 (67%)
2/6 (33%)
Sep 11, 2026 - NCAA
Dec 23, 2025 - NCAA Division I, FBS, Playoffs
Nov 29, 2025 - NCAA
Nov 14, 2025 - NCAA
Nov 8, 2025 - NCAA
Oct 25, 2025 - NCAA
3/6 (50%)
3/6 (50%)
Sep 6, 2026 - NCAA
Nov 22, 2025 - NCAA
Nov 1, 2025 - NCAA
Oct 17, 2025 - NCAA
Sep 27, 2025 - NCAA
Sep 28, 2024 - NCAA
5/6 (83%)
1/6 (17%)
Sep 12, 2026 - NCAA
Sep 7, 2026 - NCAA
Jan 2, 2026 - NCAA Division I, FBS, Playoffs
Nov 29, 2025 - NCAA
Nov 22, 2025 - NCAA
Nov 8, 2025 - NCAA
6/6 (100%)
0/6 (0%)
Sep 12, 2026 - NCAA
Jan 2, 2026 - NCAA Division I, FBS, Playoffs
Nov 22, 2025 - NCAA
Nov 1, 2025 - NCAA
Oct 11, 2025 - NCAA
Oct 4, 2025 - NCAA
3/6 (50%)
3/6 (50%)
Sep 7, 2026 - NCAA
Nov 29, 2025 - NCAA
Nov 8, 2025 - NCAA
Oct 25, 2025 - NCAA
Oct 18, 2025 - NCAA
Sep 20, 2025 - NCAA
Louisville Cardinals against SMU Mustangs : Head to Head (H2H)
0 %
100 %
Nov 22, 2025 - NCAA
Louisville Cardinals - SMU Mustangs Key Points
- The Over is 1-1 for SMU this season
- SMU is 2-0 ATS this season
- The Over is 2-0 for Louisville this season
- Louisville is 2-0 ATS this season
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Our Louisville Cardinals vs SMU Mustangs Prediction
Louisville is the small favorite in this game; however, SMU looks to be the best betting option. Both teams have been efficient offensively, as Louisville is averaging 48.5 points per game, while SMU is averaging 41.5 points per game.
Where the difference lies is defensively, as the Mustangs are allowing 17 points per game, while the Cardinals are allowing 27 points per game. Both of these teams have also covered the spread in their first two games; however, with SMU looking like the better defensive team overall early in the season, our SMU Mustangs vs. Louisville Cardinals prediction is: SMU Mustangs +1.5.
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.
