Las Vegas Raiders vs Indianapolis Colts Prediction & Picks - NFL

Prediction published on 10/5/25, 9:54 AM  by Erik Gibbs in NFL Picks

The Las Vegas Raiders will travel to Lucas Oil Stadium on Sunday to take on the Indianapolis Colts in a key AFC matchup between two teams trending in opposite directions. The Raiders enter Week 5 with a disappointing 1-3 record, having dropped three consecutive games after a heartbreaking 25-24 loss to the Chicago Bears. That defeat came in dramatic fashion, as kicker Daniel Carlson’s 54-yard field goal attempt to win the game was blocked in the final moments.

Despite showing flashes of offensive potential, Las Vegas continues to struggle in critical moments, failing to sustain drives or capitalize in the red zone. Through four games, inconsistency has plagued both sides of the ball, as the Raiders’ offensive line has allowed too much pressure while the defense has failed to create enough stops.

The Indianapolis Colts, meanwhile, have been one of the pleasant surprises of the season. Despite a 27-20 road loss to the Los Angeles Rams last week, Indianapolis remains in first place in the AFC South with a 3-1 record.

Quarterback Daniel Jones has been the catalyst for the Colts’ offensive resurgence, helping the team average an impressive 30.75 points per game. His dual-threat ability has opened up running lanes and created balance in the offense, which is averaging over 136 rushing yards per contest.

The Colts’ offensive line has also provided solid protection, allowing Jones to distribute the ball effectively to a deep group of receivers. Even with the Week 4 loss, this Indianapolis team looks cohesive, physical, and confident heading into their home matchup with Las Vegas.