Los Angeles Chargers vs Washington Commanders Prediction & Picks - NFL

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Los Angeles Chargers
10/5/25 16:25
Washington Commanders

Prediction:

 

Los Angeles Chargers ML

-155
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 by Matt Lowrimore | in NFL Picks

One of the intriguing games on the Week 5 NFL Sunday slate will see the Los Angeles Chargers take on the Washington Commanders. Let’s take a look at the match statistics and predictions for this game between the Chargers and the Commanders.

Washington enters this game with a record of 2-2, having most recently lost to the Atlanta Falcons in Week 4 by a score of 34-27. The Commanders’ offense had a total of 294 yards, while its defense allowed 435 yards. Backup quarterback Marcus Mariota threw for 156 yards, two touchdowns, and one interception, while running back Chris Rodriguez Jr. led the team in rushing with 59 yards.

As for Los Angeles, they enter this game with a record of 3-1, having most recently lost to the New York Giants in Week 4 by a score of 21-18. The Chargers’ offense had a total of 338 yards, while its defense allowed 250 yards. Quarterback Justin Herbert threw for 203 yards, one touchdown, and two interceptions, while running back Omarion Hampton led the team in rushing with 128 yards and one touchdown.

Los Angeles Chargers vs Washington Commanders Form

Table

Teams Pts P W L
9 Los Angeles Chargers
0.647 17 11 6
26 Washington Commanders
0.294 17 5 12

Los Angeles Chargers and Washington Commanders Latest Matches

Los Angeles Chargers
Los Angeles Chargers Latest matches
W L W W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 28, 2025 - NFL

New York Giants
21 :  18
Los Angeles Chargers

Sep 21, 2025 - NFL

Los Angeles Chargers
23 :  20
Denver Broncos

Sep 15, 2025 - NFL

Las Vegas Raiders
9 :  20
Los Angeles Chargers

Sep 5, 2025 - NFL

Los Angeles Chargers
27 :  21
Kansas City Chiefs

Jan 11, 2025 - NFL

Houston Texans
32 :  12
Los Angeles Chargers

Jan 5, 2025 - NFL

Las Vegas Raiders
20 :  34
Los Angeles Chargers
W L L W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Sep 21, 2025 - NFL

Los Angeles Chargers
23 :  20
Denver Broncos

Sep 5, 2025 - NFL

Los Angeles Chargers
27 :  21
Kansas City Chiefs

Dec 19, 2024 - NFL

Los Angeles Chargers
34 :  27
Denver Broncos

Dec 15, 2024 - NFL

Los Angeles Chargers
17 :  40
Tampa Bay Buccaneers

Nov 25, 2024 - NFL

Los Angeles Chargers
23 :  30
Baltimore Ravens

Nov 17, 2024 - NFL

Los Angeles Chargers
34 :  27
Cincinnati Bengals
L W W L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 28, 2025 - NFL

New York Giants
21 :  18
Los Angeles Chargers

Sep 15, 2025 - NFL

Las Vegas Raiders
9 :  20
Los Angeles Chargers

Jan 11, 2025 - NFL

Houston Texans
32 :  12
Los Angeles Chargers

Jan 5, 2025 - NFL

Las Vegas Raiders
20 :  34
Los Angeles Chargers

Dec 28, 2024 - NFL

New England Patriots
7 :  40
Los Angeles Chargers

Dec 8, 2024 - NFL

Kansas City Chiefs
19 :  17
Los Angeles Chargers
Washington Commanders
Washington Commanders Latest matches
W L W L W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 28, 2025 - NFL

Atlanta Falcons
34 :  27
Washington Commanders

Sep 21, 2025 - NFL

Washington Commanders
41 :  24
Las Vegas Raiders

Sep 11, 2025 - NFL

Green Bay Packers
27 :  18
Washington Commanders

Sep 7, 2025 - NFL

Washington Commanders
21 :  6
New York Giants

Jan 26, 2025 - NFL

Philadelphia Eagles
55 :  23
Washington Commanders

Jan 18, 2025 - NFL

Detroit Lions
31 :  45
Washington Commanders
L W W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Sep 21, 2025 - NFL

Washington Commanders
41 :  24
Las Vegas Raiders

Sep 7, 2025 - NFL

Washington Commanders
21 :  6
New York Giants

Dec 29, 2024 - NFL

Washington Commanders
30 :  24
Atlanta Falcons

Dec 22, 2024 - NFL

Washington Commanders
36 :  33
Philadelphia Eagles

Dec 1, 2024 - NFL

Washington Commanders
42 :  19
Tennessee Titans

Nov 24, 2024 - NFL

Washington Commanders
26 :  34
Dallas Cowboys
W W W L L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Sep 28, 2025 - NFL

Atlanta Falcons
34 :  27
Washington Commanders

Sep 11, 2025 - NFL

Green Bay Packers
27 :  18
Washington Commanders

Jan 26, 2025 - NFL

Philadelphia Eagles
55 :  23
Washington Commanders

Jan 18, 2025 - NFL

Detroit Lions
31 :  45
Washington Commanders

Jan 12, 2025 - NFL

Tampa Bay Buccaneers
20 :  23
Washington Commanders

Jan 5, 2025 - NFL

Dallas Cowboys
19 :  23
Washington Commanders

Los Angeles Chargers - Washington Commanders Key Points

  1. The Chargers are 3-1 ATS this season
  2. The Commanders are 2-2 ATS this season
  3. The Chargers are averaging 22.0 points per game this season
  4. The Commanders are averaging 26.8 points per game this season

Our Los Angeles Chargers vs Washington Commanders Prediction

While the Chargers failed to keep their unbeaten start to the season alive in Week 4, they look to be the better betting option against the Commanders. Especially considering that Washington’s Jayden Daniels is still questionable for this game.

Washington backup quarterback Marcus Mariota lacks the same skill set as Daniels, which was highlighted in the Week 4 loss against the Atlanta Falcons. Further, Los Angeles still has one of the toughest defenses in the NFL and has one of the top quarterbacks in the league with Justin Herbert. 

Given the uncertainty surrounding Daniels, our Los Angeles Chargers vs Washington Commanders prediction is: Los Angeles Chargers ML.

Prediction:

 

Los Angeles Chargers ML

-155
$200 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Los Angeles Chargers vs Washington Commanders Picks