Buffalo Bills vs Cleveland Browns Prediction & Picks - NFL

Prediction published on 12/21/25, 9:19 AM  by Lou Aguila in NFL Picks

The Buffalo Bills will try to stay in the hunt for the AFC East title as they go for their fourth straight win against the Cleveland Browns on Sunday at Huntington Bank Field.

The Bills, 5-1-1 ATS in their last 7 games against Cleveland, will have to overcome -10.5 point handicap in this game.

Current Form:

Bills are still in the hunt for the AFC East title after winning their last three games to improve their record to 10-4, one game behind the 11-3 New England Patriots. Last week, Buffalo registered a massive win over the Patriots, 35-31, behind an explosive offense fueled by quarterback Josh Allen and running back James Cook III. Allen passed for 193 yards with three touchdowns, and Cook III ran 109 yards and scored two TDs, including the game-winning 65-yard TD rush in the fourth quarter.

The Browns have lost their last three games, including a humiliating 3-31 loss to the Chicago Bears last week. At 3-11, Cleveland is at the bottom of the conference and division standings, missing the postseason this year after a wild-card stint in the 2024-25 NFL playoffs. With Joe Flacco traded to the Bengals, Shedeur Sanders has assumed the starting quarterback role. However, it has been a bumpy start for the young signal caller as he has posted 946 yards with five touchdowns, six interceptions and a quarterback rating of 17.0.