Dallas Cowboys vs Los Angeles Chargers Prediction & Picks - NFL

USA - NFL

Dallas Cowboys
12/21/25 13:00
Los Angeles Chargers

Prediction:

 

Los Angeles Chargers +3.5 Alternate Spread

-160
$200 offered for betting!

New customers only | Commercial content | 21+ age limit | T&Cs apply

 by Matt Lowrimore | in NFL Picks

Week 16 of the NFL continues on Sunday with a matchup that will see the Los Angeles Chargers take on the Dallas Cowboys. Let’s take a look at the match statistics and predictions for this game between the Chargers and the Cowboys.

Los Angeles enters this game with a record of 10-4, having most recently beaten the Kansas City Chiefs in Week 15 by a score of 16-13. The Chargers’ offense had a total of 295 yards, while its defense allowed 239 yards. Quarterback Justin Herbert threw for 210 yards, one touchdown, and one interception, while running back Omarion Hampton led the team in rushing with 61 yards.

As for Dallas, they enter this game with a record of 6-7-1, having most recently lost to the Minnesota Vikings in Week 15 by a score of 34-26. The Cowboys’ offense had a total of 423 yards, while its defense allowed 327 yards. Quarterback Dak Prescott threw for 294 yards, while running back Javonte Williams led the team in rushing with 91 yards and one touchdown.

Dallas Cowboys vs Los Angeles Chargers Form

Table

Teams Pts P W L
9 Los Angeles Chargers
0.647 17 11 6
21 Dallas Cowboys
0.412 17 7 9

Dallas Cowboys and Los Angeles Chargers Latest Matches

Dallas Cowboys
Dallas Cowboys Latest matches
L W W W L L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Dec 14, 2025 - NFL

Dallas Cowboys
26 :  34
Minnesota Vikings

Dec 4, 2025 - NFL

Detroit Lions
44 :  30
Dallas Cowboys

Nov 27, 2025 - NFL

Dallas Cowboys
31 :  28
Kansas City Chiefs

Nov 23, 2025 - NFL

Dallas Cowboys
24 :  21
Philadelphia Eagles

Nov 17, 2025 - NFL

Las Vegas Raiders
16 :  33
Dallas Cowboys

Nov 3, 2025 - NFL

Dallas Cowboys
17 :  27
Arizona Cardinals
D W L W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Dec 14, 2025 - NFL

Dallas Cowboys
26 :  34
Minnesota Vikings

Nov 27, 2025 - NFL

Dallas Cowboys
31 :  28
Kansas City Chiefs

Nov 23, 2025 - NFL

Dallas Cowboys
24 :  21
Philadelphia Eagles

Nov 3, 2025 - NFL

Dallas Cowboys
17 :  27
Arizona Cardinals

Oct 19, 2025 - NFL

Dallas Cowboys
44 :  22
Washington Commanders

Sep 28, 2025 - NFL

Dallas Cowboys
40 :  40
Green Bay Packers
L W L L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Dec 4, 2025 - NFL

Detroit Lions
44 :  30
Dallas Cowboys

Nov 17, 2025 - NFL

Las Vegas Raiders
16 :  33
Dallas Cowboys

Oct 26, 2025 - NFL

Denver Broncos
44 :  24
Dallas Cowboys

Oct 12, 2025 - NFL

Carolina Panthers
30 :  27
Dallas Cowboys

Oct 5, 2025 - NFL

New York Jets
22 :  37
Dallas Cowboys

Sep 21, 2025 - NFL

Chicago Bears
31 :  14
Dallas Cowboys
Los Angeles Chargers
Los Angeles Chargers Latest matches
W W L W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Dec 14, 2025 - NFL

Kansas City Chiefs
13 :  16
Los Angeles Chargers

Dec 8, 2025 - NFL

Los Angeles Chargers
22 :  19
Philadelphia Eagles

Nov 30, 2025 - NFL

Los Angeles Chargers
31 :  14
Las Vegas Raiders

Nov 16, 2025 - NFL

Jacksonville Jaguars
35 :  6
Los Angeles Chargers

Nov 9, 2025 - NFL

Los Angeles Chargers
25 :  10
Pittsburgh Steelers

Nov 2, 2025 - NFL

Tennessee Titans
20 :  27
Los Angeles Chargers
L L W W W W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Dec 8, 2025 - NFL

Los Angeles Chargers
22 :  19
Philadelphia Eagles

Nov 30, 2025 - NFL

Los Angeles Chargers
31 :  14
Las Vegas Raiders

Nov 9, 2025 - NFL

Los Angeles Chargers
25 :  10
Pittsburgh Steelers

Oct 23, 2025 - NFL

Los Angeles Chargers
37 :  10
Minnesota Vikings

Oct 19, 2025 - NFL

Los Angeles Chargers
24 :  38
Indianapolis Colts

Oct 5, 2025 - NFL

Los Angeles Chargers
10 :  27
Washington Commanders
W L W W L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Dec 14, 2025 - NFL

Kansas City Chiefs
13 :  16
Los Angeles Chargers

Nov 16, 2025 - NFL

Jacksonville Jaguars
35 :  6
Los Angeles Chargers

Nov 2, 2025 - NFL

Tennessee Titans
20 :  27
Los Angeles Chargers

Oct 12, 2025 - NFL

Miami Dolphins
27 :  29
Los Angeles Chargers

Sep 28, 2025 - NFL

New York Giants
21 :  18
Los Angeles Chargers

Sep 15, 2025 - NFL

Las Vegas Raiders
9 :  20
Los Angeles Chargers

Dallas Cowboys against Los Angeles Chargers : Head to Head (H2H)

Dallas Cowboys

100 %

Los Angeles Chargers

0 %

Oct 16, 2023 - NFL

Los Angeles Chargers
17 :  20
Dallas Cowboys

Dallas Cowboys - Los Angeles Chargers Key Points

  1. Dallas is 0-2 SU in their last two games
  2. Dallas is 4-2-1 SU at home
  3. Los Angeles is 3-0 SU in their last three games
  4. Los Angeles is 4-2 SU on the road

Our Dallas Cowboys vs Los Angeles Chargers Prediction

Dallas is the slight favorite here; however, the Chargers look to be the best betting option. For one, the Chargers have won three games in a row, while also having posted a 4-2 record on the road thus far.

The Cowboys, on the other hand, have lost their last two games in a row and, as a result, have seen their playoff chances plummet. 

Simply put, the Chargers are the better team in just about every area, so considering they are still fighting for the chance to win the AFC West division, our Dallas Cowboys vs Los Angeles Chargers prediction is: Los Angeles Chargers +3.5 Alternate Spread.

Prediction:

 

Los Angeles Chargers +3.5 Alternate Spread

-160
$200 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Dallas Cowboys vs Los Angeles Chargers Picks