Dallas Cowboys vs San Francisco 49ers Prediction & Picks - NFL

USA - NFL

Dallas Cowboys
11/15/26 16:25
San Francisco 49ers

Prediction:

 

San Francisco -4.5

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 by Bill Christy | in NFL Picks

Two of the most storied franchises in NFL history will meet Sunday afternoon at Jerry’s World. The 4-5 Dallas Cowboys will host the 7-1 San Francisco 49ers.

The Cowboys are in the midst of a typical season. Over the last decade-plus, their fans and some national media proclaim that this will be the year the Dallas Cowboys get back to the promised land. And if there were any season for them to do it, it should be this year. The Eagles are a wreck, and the Commanders and Giants are mediocre at best. However, Dallas keeps finding ways to lose games and not take that next step. It is mainly on the defensive side of the ball where they have continued to struggle. They are 25th in the NFL and are allowing an average of 26.2 points per game.

The San Francisco 49ers have been the exact opposite of this Dallas team. San Francisco has continued to make deep playoff runs and win their division over recent years. This season, they have overcome a lot of injuries and are playing some of the most complete football in the entire league. They are 6th in the NFL in scoring defense and allow just 19.5 points per game. It will be tested by this strong Dallas offense, but they are likely up for that task.

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Dallas Cowboys vs San Francisco 49ers Form

Table

Teams Pts P W L
2 San Francisco 49ers
0.875 8 7 1
17 Dallas Cowboys
0.444 9 4 5

Dallas Cowboys and San Francisco 49ers Latest Matches

Dallas Cowboys
Dallas Cowboys Latest matches
W L L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Nov 8, 2026 - NFL

Indianapolis Colts
23 :  27
Dallas Cowboys

Nov 1, 2026 - NFL

Dallas Cowboys
30 :  33
Arizona Cardinals

Oct 26, 2026 - NFL

Philadelphia Eagles
21 :  38
Dallas Cowboys

Oct 18, 2026 - NFL

Green Bay Packers
23 :  13
Dallas Cowboys

Oct 8, 2026 - NFL

Dallas Cowboys
16 :  24
Tampa Bay Buccaneers

Oct 4, 2026 - NFL

Houston Texans
30 :  34
Dallas Cowboys
L L W L L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Nov 1, 2026 - NFL

Dallas Cowboys
30 :  33
Arizona Cardinals

Oct 8, 2026 - NFL

Dallas Cowboys
16 :  24
Tampa Bay Buccaneers

Sep 27, 2026 - NFL

Dallas Cowboys
31 :  34
Baltimore Ravens

Sep 20, 2026 - NFL

Dallas Cowboys
37 :  20
Washington Commanders

Dec 21, 2025 - NFL

Dallas Cowboys
17 :  34
Los Angeles Chargers

Dec 14, 2025 - NFL

Dallas Cowboys
26 :  34
Minnesota Vikings
L L W L W W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Nov 8, 2026 - NFL

Indianapolis Colts
23 :  27
Dallas Cowboys

Oct 26, 2026 - NFL

Philadelphia Eagles
21 :  38
Dallas Cowboys

Oct 18, 2026 - NFL

Green Bay Packers
23 :  13
Dallas Cowboys

Oct 4, 2026 - NFL

Houston Texans
30 :  34
Dallas Cowboys

Sep 13, 2026 - NFL

New York Giants
28 :  20
Dallas Cowboys

Jan 4, 2026 - NFL

New York Giants
34 :  17
Dallas Cowboys
San Francisco 49ers
San Francisco 49ers Latest matches
W W W W L W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Nov 8, 2026 - NFL

San Francisco 49ers
38 :  17
Las Vegas Raiders

Oct 25, 2026 - NFL

Atlanta Falcons
29 :  20
San Francisco 49ers

Oct 19, 2026 - NFL

San Francisco 49ers
23 :  17
Washington Commanders

Oct 11, 2026 - NFL

Seattle Seahawks
29 :  32
San Francisco 49ers

Oct 4, 2026 - NFL

San Francisco 49ers
24 :  14
Denver Broncos

Sep 27, 2026 - NFL

San Francisco 49ers
36 :  30
Arizona Cardinals
L W W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Nov 8, 2026 - NFL

San Francisco 49ers
38 :  17
Las Vegas Raiders

Oct 19, 2026 - NFL

San Francisco 49ers
23 :  17
Washington Commanders

Oct 4, 2026 - NFL

San Francisco 49ers
24 :  14
Denver Broncos

Sep 27, 2026 - NFL

San Francisco 49ers
36 :  30
Arizona Cardinals

Sep 20, 2026 - NFL

San Francisco 49ers
35 :  13
Miami Dolphins

Jan 3, 2026 - NFL

San Francisco 49ers
3 :  13
Seattle Seahawks
W W L W W L
Victories

4/6 (67%)

Defeats

2/6 (33%)

Oct 25, 2026 - NFL

Atlanta Falcons
29 :  20
San Francisco 49ers

Oct 11, 2026 - NFL

Seattle Seahawks
29 :  32
San Francisco 49ers

Sep 10, 2026 - NFL

Los Angeles Rams
7 :  27
San Francisco 49ers

Jan 17, 2026 - NFL

Seattle Seahawks
41 :  6
San Francisco 49ers

Jan 11, 2026 - NFL

Philadelphia Eagles
19 :  23
San Francisco 49ers

Dec 22, 2025 - NFL

Indianapolis Colts
27 :  48
San Francisco 49ers

Dallas Cowboys against San Francisco 49ers : Head to Head (H2H)

Dallas Cowboys

0 %

San Francisco 49ers

100 %

Oct 27, 2024 - NFL

San Francisco 49ers
30 :  24
Dallas Cowboys

Oct 8, 2023 - NFL

San Francisco 49ers
42 :  10
Dallas Cowboys

Jan 22, 2023 - NFL

San Francisco 49ers
19 :  12
Dallas Cowboys

Jan 16, 2022 - NFL

Dallas Cowboys
17 :  23
San Francisco 49ers
Dallas Cowboys vs San Francisco 49ers Picks

Dallas Cowboys - San Francisco 49ers Key Points

  1. 49ers are 6-1 ATS in their last 7 games as a road favorite.
  2. 49ers are 5-0 ATS in their last 5 games following a straight up loss.
  3. Cowboys are 0-4 ATS in their last 4 meetings.
  4. Cowboys are 1-4 ATS in their last 5 games.

Our Dallas Cowboys vs San Francisco 49ers Prediction

The Cowboys are a decent-sized home dog in this matchup, and for good reason. Dallas is likely to be able to put some points up on this vaunted Niners defense, but it is going to be their Achilles' heel that will do them in once again. They are simply not going to be able to contain Christian McCaffrey, Brock Purdy, and the rest of this Niners offense. We like the Niners to take care of business here on the road and pick up the cover.

Our prediction for Dallas Cowboys vs San Francisco 49ers: San Francisco -4.5

Prediction:

 

San Francisco -4.5

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All tips are fully researched and given in good faith, but profits cannot be guaranteed.