Pittsburgh Steelers vs Detroit Lions Prediction & Picks - NFL

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Pittsburgh Steelers
12/21/25 16:25
Detroit Lions

Prediction:

 

Pittsburgh Steelers +7.5 Alternate Spread

-133
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 by Matt Lowrimore in NFL Picks

One of the better Week 16 games in the NFL will see the Pittsburgh Steelers take on the Detroit Lions. Let’s take a look at the match statistics and predictions for this game between the Lions and the Steelers.

Pittsburgh enters this game with a record of 8-6, having most recently beaten the Miami Dolphins in Week 15 by a score of 28-15. The Steelers’ offense had a total of 336 yards, while its defense allowed 285 yards. Quarterback Aaron Rodgers threw for 224 yards and two touchdowns, while running back Kenneth Gainwell led the team in rushing with 80 yards.

As for Detroit, they enter this game with a record of 8-6, having most recently lost to the Los Angeles Rams in Week 15 by a score of 41-34. The Lions’ offense had a total of 396 yards, while its defense allowed 519 yards. Quarterback Jared Goff threw for 338 yards and three touchdowns, while running back Jahmyr Gibbs led the team in rushing with 38 yards.

Pittsburgh Steelers vs Detroit Lions Form

Table

Teams % P W D L
13
Pittsburgh Steelers
Pittsburgh Steelers
0.571 14 8 0 6
15
Detroit Lions
Detroit Lions
0.571 14 8 0 6

Pittsburgh Steelers and Detroit Lions Latest Matches

Pittsburgh Steelers
Pittsburgh Steelers Latest matches
L W L L W W
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Dec 15, 2025 - NFL

Miami Dolphins
15 :  28
Pittsburgh Steelers

Dec 7, 2025 - NFL

Pittsburgh Steelers
27 :  22
Baltimore Ravens

Nov 30, 2025 - NFL

Buffalo Bills
26 :  7
Pittsburgh Steelers

Nov 23, 2025 - NFL

Pittsburgh Steelers
28 :  31
Chicago Bears

Nov 16, 2025 - NFL

Cincinnati Bengals
12 :  34
Pittsburgh Steelers

Nov 9, 2025 - NFL

Pittsburgh Steelers
10 :  25
Los Angeles Chargers
W L W W L W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Dec 15, 2025 - NFL

Miami Dolphins
15 :  28
Pittsburgh Steelers

Nov 30, 2025 - NFL

Buffalo Bills
26 :  7
Pittsburgh Steelers

Nov 16, 2025 - NFL

Cincinnati Bengals
12 :  34
Pittsburgh Steelers

Nov 2, 2025 - NFL

Indianapolis Colts
20 :  27
Pittsburgh Steelers

Oct 26, 2025 - NFL

Green Bay Packers
35 :  25
Pittsburgh Steelers

Oct 12, 2025 - NFL

Cleveland Browns
9 :  23
Pittsburgh Steelers
W W L L L W
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Dec 7, 2025 - NFL

Pittsburgh Steelers
27 :  22
Baltimore Ravens

Nov 23, 2025 - NFL

Pittsburgh Steelers
28 :  31
Chicago Bears

Nov 9, 2025 - NFL

Pittsburgh Steelers
10 :  25
Los Angeles Chargers

Oct 16, 2025 - NFL

Pittsburgh Steelers
31 :  33
Cincinnati Bengals

Sep 21, 2025 - NFL

Pittsburgh Steelers
21 :  14
New England Patriots

Sep 7, 2025 - NFL

Pittsburgh Steelers
34 :  32
New York Jets
Detroit Lions
Detroit Lions Latest matches
W L W L W L
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Dec 14, 2025 - NFL

Detroit Lions
34 :  41
Los Angeles Rams

Dec 4, 2025 - NFL

Dallas Cowboys
30 :  44
Detroit Lions

Nov 27, 2025 - NFL

Green Bay Packers
31 :  24
Detroit Lions

Nov 23, 2025 - NFL

New York Giants
27 :  34
Detroit Lions

Nov 16, 2025 - NFL

Detroit Lions
9 :  16
Philadelphia Eagles

Nov 9, 2025 - NFL

Detroit Lions
44 :  22
Washington Commanders
W W L W L W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Dec 4, 2025 - NFL

Dallas Cowboys
30 :  44
Detroit Lions

Nov 27, 2025 - NFL

Green Bay Packers
31 :  24
Detroit Lions

Nov 23, 2025 - NFL

New York Giants
27 :  34
Detroit Lions

Nov 2, 2025 - NFL

Minnesota Vikings
27 :  24
Detroit Lions

Oct 20, 2025 - NFL

Tampa Bay Buccaneers
9 :  24
Detroit Lions

Sep 28, 2025 - NFL

Cleveland Browns
10 :  34
Detroit Lions
W W L W L L
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Dec 14, 2025 - NFL

Detroit Lions
34 :  41
Los Angeles Rams

Nov 16, 2025 - NFL

Detroit Lions
9 :  16
Philadelphia Eagles

Nov 9, 2025 - NFL

Detroit Lions
44 :  22
Washington Commanders

Oct 12, 2025 - NFL

Detroit Lions
17 :  30
Kansas City Chiefs

Oct 5, 2025 - NFL

Detroit Lions
37 :  24
Cincinnati Bengals

Sep 22, 2025 - NFL

Detroit Lions
38 :  30
Baltimore Ravens

Pittsburgh Steelers against Detroit Lions : Head to Head (H2H)

Nov 14, 2021 - NFL

Detroit Lions
16 :  16
Pittsburgh Steelers

Pittsburgh Steelers - Detroit Lions Key Points

  1. Pittsburgh is 3-3 SU on the road
  2. Pittsburgh is 2-0 SU in their last two games
  3. Detroit is 5-2 SU at home
  4. Detroit is 2-3 SU in their last five games

Our Pittsburgh Steelers vs Detroit Lions Prediction

The Lions are about a touchdown favorite in this matchup; however, the Steelers look to be the best betting option. Detroit is in danger of missing the playoffs as they have a mediocre record. Their offense has been excellent at times this season, but their defense has also allowed a ton of points over the last few weeks.

The Steelers, on the other hand, are fighting for the AFC North division, which they lead by one game as it stands. Pittsburgh has also won back-to-back games and has been improving every week. 

As good as the Lions’ offense has been, their defense has let them down on numerous occasions. Because of that, our Detroit Lions vs Pittsburgh Steelers prediction is: Pittsburgh Steelers +7.5 Alternate Spread.

Prediction:

 

Pittsburgh Steelers +7.5 Alternate Spread

-133
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Pittsburgh Steelers vs Detroit Lions Picks