Oregon Ducks vs James Madison Dukes Prediction & Picks - NCAA

USA - NCAA

Oregon Ducks
12/20/25 19:30
James Madison Dukes

Prediction:

 

James Madison Dukes +21.5 Alternate Spread

-131
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 by Matt Lowrimore | in NCAA Picks

The final College Football Playoff first-round game will see the 12th-seeded James Madison Dukes take on the 5th-seeded Oregon Ducks. Let’s take a look at the match statistics and predictions for this game between the Dukes and the Ducks. 

James Madison enters this game having finished the regular season with a record of 12-1. The Dukes most recently beat the Troy Trojans in the Sun Belt Championship by a score of 31-14. James Madison’s offense had a total of 411 yards, while its defense allowed 177 yards. Quarterback Alonza Barnett III threw for 93 yards, one touchdown, and one interception, while running back Wayne Knight led the team in rushing with 212 yards and one touchdown.

As for Oregon, they enter this game having finished the regular season with a record of 11-1. The Ducks most recently beat the Washington Huskies by a score of 26-14 back in Week 14. Oregon’s offense had a total of 392 yards, while its defense allowed 283 yards. Quarterback Dante Moore threw for 286 yards and one touchdown, while running back Noah Whittington led the team in rushing with 47 yards.

Oregon Ducks vs James Madison Dukes Form

Oregon Ducks and James Madison Dukes Latest Matches

Oregon Ducks
Oregon Ducks Latest matches
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Nov 29, 2025 - NCAA

Washington Huskies
14 :  26
Oregon Ducks

Nov 22, 2025 - NCAA

Oregon Ducks
42 :  27
USC Trojans

Nov 14, 2025 - NCAA

Oregon Ducks
42 :  13
Minnesota Golden Gophers

Nov 8, 2025 - NCAA

Iowa Hawkeyes
16 :  18
Oregon Ducks

Oct 25, 2025 - NCAA

Oregon Ducks
21 :  7
Wisconsin Badgers

Oct 18, 2025 - NCAA

Rutgers Scarlet Knights
10 :  56
Oregon Ducks
W W L W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Nov 22, 2025 - NCAA

Oregon Ducks
42 :  27
USC Trojans

Nov 14, 2025 - NCAA

Oregon Ducks
42 :  13
Minnesota Golden Gophers

Oct 25, 2025 - NCAA

Oregon Ducks
21 :  7
Wisconsin Badgers

Oct 11, 2025 - NCAA

Oregon Ducks
20 :  30
Indiana Hoosiers

Sep 20, 2025 - NCAA

Oregon Ducks
41 :  7
Oregon State Beavers

Sep 6, 2025 - NCAA

Oregon Ducks
69 :  3
Oklahoma State Cowboys
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Nov 29, 2025 - NCAA

Washington Huskies
14 :  26
Oregon Ducks

Nov 8, 2025 - NCAA

Iowa Hawkeyes
16 :  18
Oregon Ducks

Oct 18, 2025 - NCAA

Rutgers Scarlet Knights
10 :  56
Oregon Ducks

Sep 27, 2025 - NCAA

Penn State Nittany Lions
24 :  30
Oregon Ducks

Sep 13, 2025 - NCAA

Northwestern Wildcats
14 :  34
Oregon Ducks

Sep 28, 2024 - NCAA

UCLA Bruins
13 :  34
Oregon Ducks
James Madison Dukes
James Madison Dukes Latest matches
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Dec 5, 2025 - NCAA

James Madison Dukes
31 :  14
Troy Trojans

Nov 29, 2025 - NCAA

Coastal Carolina Chanticleers
10 :  59
James Madison Dukes

Nov 22, 2025 - NCAA

James Madison Dukes
24 :  20
Washington State Cougars

Nov 15, 2025 - NCAA

James Madison Dukes
58 :  10
Appalachian State Mountaineers

Nov 8, 2025 - NCAA

Marshall Herd
23 :  35
James Madison Dukes

Oct 28, 2025 - NCAA

Texas State Bobcats
20 :  52
James Madison Dukes
W W W W W W
Victories

6/6 (100%)

Defeats

0/6 (0%)

Dec 5, 2025 - NCAA

James Madison Dukes
31 :  14
Troy Trojans

Nov 22, 2025 - NCAA

James Madison Dukes
24 :  20
Washington State Cougars

Nov 15, 2025 - NCAA

James Madison Dukes
58 :  10
Appalachian State Mountaineers

Oct 18, 2025 - NCAA

James Madison Dukes
63 :  27
Old Dominion Monarchs

Oct 11, 2025 - NCAA

James Madison Dukes
24 :  14
Louisiana Ragin Cajuns

Sep 27, 2025 - NCAA

James Madison Dukes
35 :  10
Georgia Southern Eagles
L W W W W W
Victories

5/6 (83%)

Defeats

1/6 (17%)

Nov 29, 2025 - NCAA

Coastal Carolina Chanticleers
10 :  59
James Madison Dukes

Nov 8, 2025 - NCAA

Marshall Herd
23 :  35
James Madison Dukes

Oct 28, 2025 - NCAA

Texas State Bobcats
20 :  52
James Madison Dukes

Oct 4, 2025 - NCAA

Georgia State Panthers
7 :  14
James Madison Dukes

Sep 20, 2025 - NCAA

Liberty Flames
13 :  31
James Madison Dukes

Sep 5, 2025 - NCAA

Louisville Cardinals
28 :  14
James Madison Dukes

Oregon Ducks - James Madison Dukes Key Points

  1. James Madison is averaging 37.3 points per game
  2. James Madison is allowing 15.8 points per game
  3. Oregon is averaging 38.1 points per game
  4. Oregon is allowing 14.8 points per game

Our Oregon Ducks vs James Madison Dukes Prediction

This matchup is the most lopsided in the first round of the College Football Playoffs as Oregon is more than a three-touchdown favorite. As big as this spread is, James Madison looks to be a decent betting option. Admittedly, the Ducks have won the majority of their games by a wide margin this season. They have playmakers all over the field, and their defense is allowing just 14.8 points per game. 

That being said, James Madison has been extremely efficient offensively, especially running the ball, as they average 245.8 rushing yards per game. The Dukes are also very good defensively, allowing just 15.8 points per game. 

There is the fact that James Madison has not faced an opponent this season that compares to Oregon. However, with their ability to control the time of possession, our James Madison Dukes vs Oregon Ducks prediction is: James Madison Dukes +21.5 Alternate Spread.

Prediction:

 

James Madison Dukes +21.5 Alternate Spread

-131
$200 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Oregon Ducks vs James Madison Dukes Picks