Missouri Tigers vs Oklahoma Sooners Prediction & Picks - NCAA

USA - NCAA

Missouri Tigers
11/22/25 12:00
Oklahoma Sooners

Prediction:

 

Missouri Tigers +7.5

-112
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 by Matt Lowrimore in NCAA Picks

The Week 13 College Football slate features a ton of interesting games, including one that will see the 22nd-ranked Missouri Tigers take on the 8th-ranked Oklahoma Sooners in the SEC. Let’s take a look at the match statistics and predictions for this game between the Tigers and the Sooners.

Missouri enters this game with a record of 7-3 and 3-3 in the SEC. The Tigers most recently beat the Mississippi State Bulldogs in Week 12 by a score of 49-27. Missouri’s offense had a total of 438 yards, while its defense allowed 345 yards. Quarterback Matt Zollers threw for 112 yards, two touchdowns, and one interception, while running back Ahmad Hardy led the team in rushing with 300 yards and three touchdowns.

As for Oklahoma, they enter this game with a record of 8-2 and 4-2 in the SEC. The Sooners most recently beat the Alabama Crimson Tide in Week 12 by a score of 23-21. Oklahoma’s offense had a total of 212 yards, while its defense allowed 406 yards. Quarterback John Mateer threw for 138 yards, while running back Xavier Robinson led the team in rushing with 34 yards.

Missouri Tigers vs Oklahoma Sooners Form

Table

Teams % P W D L
6
Oklahoma Sooners
Oklahoma Sooners
0.667 6 4 0 2
9
Missouri Tigers
Missouri Tigers
0.5 6 3 0 3

Missouri Tigers and Oklahoma Sooners Latest Matches

Missouri Tigers
Missouri Tigers Latest matches
W L W L L W
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Nov 15, 2025 - NCAA

Mississippi State Bulldogs
27 :  49
Missouri Tigers

Nov 8, 2025 - NCAA

Texas AM Aggies
38 :  17
Missouri Tigers

Oct 25, 2025 - NCAA

Missouri Tigers
10 :  17
Vanderbilt Commodores

Oct 18, 2025 - NCAA

Missouri Tigers
23 :  17
Auburn Tigers

Oct 11, 2025 - NCAA

Alabama Crimson Tide
27 :  24
Missouri Tigers

Sep 27, 2025 - NCAA

UMass Minutemen
6 :  42
Missouri Tigers
W W W L L W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Nov 15, 2025 - NCAA

Mississippi State Bulldogs
27 :  49
Missouri Tigers

Nov 8, 2025 - NCAA

Texas AM Aggies
38 :  17
Missouri Tigers

Oct 11, 2025 - NCAA

Alabama Crimson Tide
27 :  24
Missouri Tigers

Sep 27, 2025 - NCAA

UMass Minutemen
6 :  42
Missouri Tigers

Sep 20, 2025 - NCAA

South Carolina Gamecocks
20 :  29
Missouri Tigers

Sep 13, 2025 - NCAA

Louisiana-Lafayette Ragin Cajuns
10 :  52
Missouri Tigers
L L W W L
Victories

2/4 (50%)

Draw

0/4 (0%)

Defeats

2/4 (50%)

Oct 25, 2025 - NCAA

Missouri Tigers
10 :  17
Vanderbilt Commodores

Oct 18, 2025 - NCAA

Missouri Tigers
23 :  17
Auburn Tigers

Nov 23, 2024 - NCAA

Missouri Tigers
39 :  20
Mississippi State Bulldogs

Oct 5, 2024 - NCAA

Missouri Tigers
10 :  41
Texas AM Aggies
Oklahoma Sooners
Oklahoma Sooners Latest matches
W L W L W W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Nov 15, 2025 - NCAA

Oklahoma Sooners
23 :  21
Alabama Crimson Tide

Nov 1, 2025 - NCAA

Oklahoma Sooners
33 :  27
Tennessee Volunteers

Oct 25, 2025 - NCAA

Ole Miss Rebels
34 :  26
Oklahoma Sooners

Oct 18, 2025 - NCAA

Oklahoma Sooners
26 :  7
South Carolina Gamecocks

Oct 11, 2025 - NCAA

Oklahoma Sooners
6 :  23
Texas Longhorns

Oct 4, 2025 - NCAA

Kent State Golden Flashes
0 :  44
Oklahoma Sooners
W W W W W L
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Oct 25, 2025 - NCAA

Ole Miss Rebels
34 :  26
Oklahoma Sooners

Oct 4, 2025 - NCAA

Kent State Golden Flashes
0 :  44
Oklahoma Sooners

Sep 20, 2025 - NCAA

Auburn Tigers
17 :  24
Oklahoma Sooners

Sep 6, 2025 - NCAA

Michigan Wolverines
13 :  24
Oklahoma Sooners

Aug 30, 2025 - NCAA

Illinois State Redbirds
3 :  35
Oklahoma Sooners

Nov 23, 2024 - NCAA

Alabama Crimson Tide
3 :  24
Oklahoma Sooners
L W L W W W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Nov 15, 2025 - NCAA

Oklahoma Sooners
23 :  21
Alabama Crimson Tide

Nov 1, 2025 - NCAA

Oklahoma Sooners
33 :  27
Tennessee Volunteers

Oct 18, 2025 - NCAA

Oklahoma Sooners
26 :  7
South Carolina Gamecocks

Oct 11, 2025 - NCAA

Oklahoma Sooners
6 :  23
Texas Longhorns

Sep 13, 2025 - NCAA

Oklahoma Sooners
42 :  3
Temple Owls

Dec 27, 2024 - NCAA Division I, FBS, Playoffs

Oklahoma Sooners
20 :  21
Navy Midshipmen

Missouri Tigers - Oklahoma Sooners Key Points

  1. Missouri is 3-3 ATS vs the SEC
  2. Missouri is averaging 25.3 points per game vs the SEC
  3. Oklahoma is 4-2 ATS vs the SEC
  4. Oklahoma is averaging 23.0 points per game vs the SEC

Our Missouri Tigers vs Oklahoma Sooners Prediction

Oklahoma is just over a touchdown favorite, and even though they just beat Alabama, their offense has not been the most consistent, especially against conference opponents. The Sooners are averaging just 23.0 points per game against SEC opponents in six conference games.

As for Missouri, their starting quarterback, Beau Pribula, is still dealing with an injury; however, there is some hope that he will be back under center against the Sooners. Overall, the Tigers are averaging 25.3 points per game against SEC opponents.

Even though Oklahoma’s defense has been a big reason for their success, their offense is a bit too inconsistent to trust. For that reason, our Missouri Tigers vs Oklahoma Sooners prediction is: Missouri Tigers +7.5.

Prediction:

 

Missouri Tigers +7.5

-112
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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Missouri Tigers vs Oklahoma Sooners Picks