Los Angeles Chargers vs Dallas Cowboys Prediction & Picks - NFL

USA - NFL

Los Angeles Chargers
12/21/25 13:00
Dallas Cowboys

Prediction:

 

Los Angeles Chargers +3.5 Alternate Spread

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 by Matt Lowrimore in NFL Picks

Week 16 of the NFL continues on Sunday with a matchup that will see the Los Angeles Chargers take on the Dallas Cowboys. Let’s take a look at the match statistics and predictions for this game between the Chargers and the Cowboys.

Los Angeles enters this game with a record of 10-4, having most recently beaten the Kansas City Chiefs in Week 15 by a score of 16-13. The Chargers’ offense had a total of 295 yards, while its defense allowed 239 yards. Quarterback Justin Herbert threw for 210 yards, one touchdown, and one interception, while running back Omarion Hampton led the team in rushing with 61 yards.

As for Dallas, they enter this game with a record of 6-7-1, having most recently lost to the Minnesota Vikings in Week 15 by a score of 34-26. The Cowboys’ offense had a total of 423 yards, while its defense allowed 327 yards. Quarterback Dak Prescott threw for 294 yards, while running back Javonte Williams led the team in rushing with 91 yards and one touchdown.

Los Angeles Chargers vs Dallas Cowboys Form

Table

Teams % P W D L
5
Los Angeles Chargers
Los Angeles Chargers
0.714 14 10 0 4
19
Dallas Cowboys
Dallas Cowboys
0.429 14 6 1 7

Los Angeles Chargers and Dallas Cowboys Latest Matches

Los Angeles Chargers
Los Angeles Chargers Latest matches
W W L W W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Dec 14, 2025 - NFL

Los Angeles Chargers
16 :  13
Kansas City Chiefs

Dec 8, 2025 - NFL

Philadelphia Eagles
19 :  22
Los Angeles Chargers

Nov 30, 2025 - NFL

Las Vegas Raiders
14 :  31
Los Angeles Chargers

Nov 16, 2025 - NFL

Los Angeles Chargers
6 :  35
Jacksonville Jaguars

Nov 9, 2025 - NFL

Pittsburgh Steelers
10 :  25
Los Angeles Chargers

Nov 2, 2025 - NFL

Los Angeles Chargers
27 :  20
Tennessee Titans
L L W W W W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Dec 8, 2025 - NFL

Philadelphia Eagles
19 :  22
Los Angeles Chargers

Nov 30, 2025 - NFL

Las Vegas Raiders
14 :  31
Los Angeles Chargers

Nov 9, 2025 - NFL

Pittsburgh Steelers
10 :  25
Los Angeles Chargers

Oct 23, 2025 - NFL

Minnesota Vikings
10 :  37
Los Angeles Chargers

Oct 19, 2025 - NFL

Indianapolis Colts
38 :  24
Los Angeles Chargers

Oct 5, 2025 - NFL

Washington Commanders
27 :  10
Los Angeles Chargers
W L W W L W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Dec 14, 2025 - NFL

Los Angeles Chargers
16 :  13
Kansas City Chiefs

Nov 16, 2025 - NFL

Los Angeles Chargers
6 :  35
Jacksonville Jaguars

Nov 2, 2025 - NFL

Los Angeles Chargers
27 :  20
Tennessee Titans

Oct 12, 2025 - NFL

Los Angeles Chargers
29 :  27
Miami Dolphins

Sep 28, 2025 - NFL

Los Angeles Chargers
18 :  21
New York Giants

Sep 15, 2025 - NFL

Los Angeles Chargers
20 :  9
Las Vegas Raiders
Dallas Cowboys
Dallas Cowboys Latest matches
L W W W L L
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Dec 14, 2025 - NFL

Minnesota Vikings
34 :  26
Dallas Cowboys

Dec 4, 2025 - NFL

Dallas Cowboys
30 :  44
Detroit Lions

Nov 27, 2025 - NFL

Kansas City Chiefs
28 :  31
Dallas Cowboys

Nov 23, 2025 - NFL

Philadelphia Eagles
21 :  24
Dallas Cowboys

Nov 17, 2025 - NFL

Dallas Cowboys
33 :  16
Las Vegas Raiders

Nov 3, 2025 - NFL

Arizona Cardinals
27 :  17
Dallas Cowboys
D W L W W L
Victories

3/6 (50%)

Draw

1/6 (17%)

Defeats

2/6 (33%)

Dec 14, 2025 - NFL

Minnesota Vikings
34 :  26
Dallas Cowboys

Nov 27, 2025 - NFL

Kansas City Chiefs
28 :  31
Dallas Cowboys

Nov 23, 2025 - NFL

Philadelphia Eagles
21 :  24
Dallas Cowboys

Nov 3, 2025 - NFL

Arizona Cardinals
27 :  17
Dallas Cowboys

Oct 19, 2025 - NFL

Washington Commanders
22 :  44
Dallas Cowboys

Sep 28, 2025 - NFL

Green Bay Packers
40 :  40
Dallas Cowboys
L W L L W L
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Dec 4, 2025 - NFL

Dallas Cowboys
30 :  44
Detroit Lions

Nov 17, 2025 - NFL

Dallas Cowboys
33 :  16
Las Vegas Raiders

Oct 26, 2025 - NFL

Dallas Cowboys
24 :  44
Denver Broncos

Oct 12, 2025 - NFL

Dallas Cowboys
27 :  30
Carolina Panthers

Oct 5, 2025 - NFL

Dallas Cowboys
37 :  22
New York Jets

Sep 21, 2025 - NFL

Dallas Cowboys
14 :  31
Chicago Bears

Los Angeles Chargers against Dallas Cowboys : Head to Head (H2H)

Oct 16, 2023 - NFL

Dallas Cowboys
20 :  17
Los Angeles Chargers

Los Angeles Chargers - Dallas Cowboys Key Points

  1. Dallas is 0-2 SU in their last two games
  2. Dallas is 4-2-1 SU at home
  3. Los Angeles is 3-0 SU in their last three games
  4. Los Angeles is 4-2 SU on the road

Our Los Angeles Chargers vs Dallas Cowboys Prediction

Dallas is the slight favorite here; however, the Chargers look to be the best betting option. For one, the Chargers have won three games in a row, while also having posted a 4-2 record on the road thus far.

The Cowboys, on the other hand, have lost their last two games in a row and, as a result, have seen their playoff chances plummet. 

Simply put, the Chargers are the better team in just about every area, so considering they are still fighting for the chance to win the AFC West division, our Dallas Cowboys vs Los Angeles Chargers prediction is: Los Angeles Chargers +3.5 Alternate Spread.

Prediction:

 

Los Angeles Chargers +3.5 Alternate Spread

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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Los Angeles Chargers vs Dallas Cowboys Picks