Jacksonville Jaguars vs Arizona Cardinals Prediction & Picks - NFL

USA - NFL

Jacksonville Jaguars
11/23/25 16:05
Arizona Cardinals

Prediction:

 

Arizona +3

-110
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 by Bill Christy in NFL Picks

The Arizona Cardinals (3-7) will look to avoid another losing streak as they host the Jacksonville Jaguars (6-4) this Sunday afternoon. The Jags, on the other hand, are looking to keep some hope that they can steal the division over the current leaders, Indianapolis Colts.

The Cardinals finally snapped a 5-game losing streak 3 weeks ago when they defeated the Cowboys 27-17. Since then, they dropped both games. A 44-22 loss to Seattle was followed by a 41-22 loss to the Niners last week. They will once again be without Marvin Harrison Jr and Jacoby Brissett will be under center once again as Kyler Murray remains on the IR. If things are going to turn around at all for this Cardinals team, it is going to have to start with the defense that is now giving up over 25.5 points per game.

For the Jaguars, they are coming off a dominate win over the Los Angeles Chargers last week. The rushing game was stellar for the Jags as they posted nearly 200 yards on the ground in the 35-6 win. The defense was just as impressive, holding the Chargers to just 135 total yards and sacking Justin Herbert 3 times.

The Cardinals are going to be tested by this tough rushing attack of the Jaguars. If they are not up to the task, the result could be just as ugly as their last two games

Jacksonville Jaguars vs Arizona Cardinals Form

Table

Teams % P W D L
12
Jacksonville Jaguars
Jacksonville Jaguars
0.6 10 6 0 4
25
Arizona Cardinals
Arizona Cardinals
0.3 10 3 0 7

Jacksonville Jaguars and Arizona Cardinals Latest Matches

Jacksonville Jaguars
Jacksonville Jaguars Latest matches
W L L W L W
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Nov 16, 2025 - NFL

Los Angeles Chargers
6 :  35
Jacksonville Jaguars

Nov 9, 2025 - NFL

Jacksonville Jaguars
29 :  36
Houston Texans

Nov 2, 2025 - NFL

Jacksonville Jaguars
30 :  29
Las Vegas Raiders

Oct 19, 2025 - NFL

Los Angeles Rams
35 :  7
Jacksonville Jaguars

Oct 12, 2025 - NFL

Seattle Seahawks
20 :  12
Jacksonville Jaguars

Oct 6, 2025 - NFL

Kansas City Chiefs
28 :  31
Jacksonville Jaguars
W W W L L W
Victories

4/6 (67%)

Draw

0/6 (0%)

Defeats

2/6 (33%)

Nov 16, 2025 - NFL

Los Angeles Chargers
6 :  35
Jacksonville Jaguars

Oct 19, 2025 - NFL

Los Angeles Rams
35 :  7
Jacksonville Jaguars

Oct 12, 2025 - NFL

Seattle Seahawks
20 :  12
Jacksonville Jaguars

Oct 6, 2025 - NFL

Kansas City Chiefs
28 :  31
Jacksonville Jaguars

Sep 21, 2025 - NFL

Houston Texans
10 :  17
Jacksonville Jaguars

Sep 7, 2025 - NFL

Carolina Panthers
10 :  26
Jacksonville Jaguars
L L L W W L
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Nov 9, 2025 - NFL

Jacksonville Jaguars
29 :  36
Houston Texans

Nov 2, 2025 - NFL

Jacksonville Jaguars
30 :  29
Las Vegas Raiders

Sep 28, 2025 - NFL

Jacksonville Jaguars
26 :  21
San Francisco 49ers

Sep 14, 2025 - NFL

Jacksonville Jaguars
27 :  31
Cincinnati Bengals

Jan 5, 2025 - NFL

Jacksonville Jaguars
23 :  26
Indianapolis Colts

Dec 22, 2024 - NFL

Jacksonville Jaguars
14 :  19
Las Vegas Raiders
Arizona Cardinals
Arizona Cardinals Latest matches
L L L W L L
Victories

1/6 (17%)

Draw

0/6 (0%)

Defeats

5/6 (83%)

Nov 16, 2025 - NFL

San Francisco 49ers
41 :  22
Arizona Cardinals

Nov 9, 2025 - NFL

Arizona Cardinals
22 :  44
Seattle Seahawks

Nov 3, 2025 - NFL

Arizona Cardinals
27 :  17
Dallas Cowboys

Oct 19, 2025 - NFL

Green Bay Packers
27 :  23
Arizona Cardinals

Oct 12, 2025 - NFL

Arizona Cardinals
27 :  31
Indianapolis Colts

Oct 5, 2025 - NFL

Tennessee Titans
22 :  21
Arizona Cardinals
W W L L L L
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Nov 16, 2025 - NFL

San Francisco 49ers
41 :  22
Arizona Cardinals

Oct 19, 2025 - NFL

Green Bay Packers
27 :  23
Arizona Cardinals

Oct 5, 2025 - NFL

Tennessee Titans
22 :  21
Arizona Cardinals

Sep 25, 2025 - NFL

Seattle Seahawks
23 :  20
Arizona Cardinals

Sep 14, 2025 - NFL

Carolina Panthers
22 :  27
Arizona Cardinals

Jan 5, 2025 - NFL

San Francisco 49ers
24 :  47
Arizona Cardinals
L W L L W L
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Nov 9, 2025 - NFL

Arizona Cardinals
22 :  44
Seattle Seahawks

Nov 3, 2025 - NFL

Arizona Cardinals
27 :  17
Dallas Cowboys

Oct 12, 2025 - NFL

Arizona Cardinals
27 :  31
Indianapolis Colts

Sep 21, 2025 - NFL

Arizona Cardinals
15 :  16
San Francisco 49ers

Sep 7, 2025 - NFL

Arizona Cardinals
20 :  13
New Orleans Saints

Dec 28, 2024 - NFL

Arizona Cardinals
9 :  13
Los Angeles Rams

Jacksonville Jaguars against Arizona Cardinals : Head to Head (H2H)

Sep 26, 2021 - NFL

Arizona Cardinals
31 :  19
Jacksonville Jaguars

Jacksonville Jaguars - Arizona Cardinals Key Points

  1. Jacksonville is 1-4 ATS in its last 5 games.
  2. Jacksonville is 2-19 ATS in its last 21 games against an opponent in the NFC West.
  3. Arizona is 4-1 ATS in its last 5 games against Jacksonville.
  4. Arizona is 9-3 ATS in its last 12 games when playing as the underdog.

Our Jacksonville Jaguars vs Arizona Cardinals Prediction

This spread looks so trappy. How are the Jaguars being set as less than a field goal favorite in this one? The Jags just dismantled a decent Chargers team while this Cardinals team has looked like they are packing it in for the season. In a game where the spread should be closer to a touchdown, we smell something fishy. We are going to back the Cardinals here at home and wouldn’t be shocked if they somehow pull off the upset victory.

Our prediction for Arizona Cardinals vs Jacksonville Jaguars: Arizona +3

Prediction:

 

Arizona +3

-110
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Jacksonville Jaguars vs Arizona Cardinals Picks