Indianapolis Colts vs Kansas City Chiefs Prediction & Picks - NFL

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Indianapolis Colts
11/23/25 13:00
Kansas City Chiefs

Prediction:

 

Indianapolis Colts +3.5

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 by Matt Lowrimore in NFL Picks

One of the important games on the Week 12 NFL Sunday slate will see the Kansas City Chiefs take on the Indianapolis Colts. Let’s take a look at the match statistics and predictions for this game between the Chiefs and the Colts.

Indianapolis enters this game with a record of 8-2, having most recently beaten the Atlanta Falcons in Week 10 by a score of 31-25. The Colts’ offense had a total of 519 yards, while its defense allowed 290 yards. Quarterback Daniel Jones threw for 255 yards, one touchdown, and one interception, while running back Jonathan Taylor led the team in rushing with 244 yards and three touchdowns.

As for Kansas City, they enter this game with a record of 5-5, having most recently lost to the Denver Broncos in Week 11 by a score of 22-19. Kansas City’s offense had a total of 311 yards, while its defense allowed 342 yards. Quarterback Patrick Mahomes threw for 276 yards, one touchdown, and one interception, while running back Kareem Hunt led the team in rushing with 59 yards and one touchdown.

Indianapolis Colts vs Kansas City Chiefs Form

Table

Teams % P W D L
5
Indianapolis Colts
Indianapolis Colts
0.8 10 8 0 2
18
Kansas City Chiefs
Kansas City Chiefs
0.5 10 5 0 5

Indianapolis Colts and Kansas City Chiefs Latest Matches

Indianapolis Colts
Indianapolis Colts Latest matches
W W W W L W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Nov 9, 2025 - NFL

Atlanta Falcons
25 :  31
Indianapolis Colts

Nov 2, 2025 - NFL

Indianapolis Colts
20 :  27
Pittsburgh Steelers

Oct 26, 2025 - NFL

Tennessee Titans
14 :  38
Indianapolis Colts

Oct 19, 2025 - NFL

Indianapolis Colts
38 :  24
Los Angeles Chargers

Oct 12, 2025 - NFL

Arizona Cardinals
27 :  31
Indianapolis Colts

Oct 5, 2025 - NFL

Las Vegas Raiders
6 :  40
Indianapolis Colts
W W W W W W
Victories

6/6 (100%)

Draw

0/6 (0%)

Defeats

0/6 (0%)

Nov 9, 2025 - NFL

Atlanta Falcons
25 :  31
Indianapolis Colts

Oct 26, 2025 - NFL

Tennessee Titans
14 :  38
Indianapolis Colts

Oct 12, 2025 - NFL

Arizona Cardinals
27 :  31
Indianapolis Colts

Oct 5, 2025 - NFL

Las Vegas Raiders
6 :  40
Indianapolis Colts

Sep 14, 2025 - NFL

Denver Broncos
28 :  29
Indianapolis Colts

Sep 7, 2025 - NFL

Miami Dolphins
8 :  33
Indianapolis Colts
L L W L W L
Victories

2/6 (33%)

Draw

0/6 (0%)

Defeats

4/6 (67%)

Nov 2, 2025 - NFL

Indianapolis Colts
20 :  27
Pittsburgh Steelers

Oct 19, 2025 - NFL

Indianapolis Colts
38 :  24
Los Angeles Chargers

Sep 28, 2025 - NFL

Indianapolis Colts
20 :  27
Los Angeles Rams

Sep 21, 2025 - NFL

Indianapolis Colts
41 :  20
Tennessee Titans

Dec 29, 2024 - NFL

Indianapolis Colts
33 :  45
New York Giants

Dec 15, 2024 - NFL

Indianapolis Colts
13 :  31
Denver Broncos
Kansas City Chiefs
Kansas City Chiefs Latest matches
L W W W L L
Victories

3/6 (50%)

Draw

0/6 (0%)

Defeats

3/6 (50%)

Nov 16, 2025 - NFL

Kansas City Chiefs
19 :  22
Denver Broncos

Nov 2, 2025 - NFL

Kansas City Chiefs
21 :  28
Buffalo Bills

Oct 27, 2025 - NFL

Washington Commanders
7 :  28
Kansas City Chiefs

Oct 19, 2025 - NFL

Las Vegas Raiders
0 :  31
Kansas City Chiefs

Oct 12, 2025 - NFL

Detroit Lions
17 :  30
Kansas City Chiefs

Oct 6, 2025 - NFL

Kansas City Chiefs
28 :  31
Jacksonville Jaguars
W L W W W W
Victories

5/6 (83%)

Draw

0/6 (0%)

Defeats

1/6 (17%)

Oct 27, 2025 - NFL

Washington Commanders
7 :  28
Kansas City Chiefs

Oct 19, 2025 - NFL

Las Vegas Raiders
0 :  31
Kansas City Chiefs

Oct 12, 2025 - NFL

Detroit Lions
17 :  30
Kansas City Chiefs

Sep 28, 2025 - NFL

Baltimore Ravens
20 :  37
Kansas City Chiefs

Sep 14, 2025 - NFL

Philadelphia Eagles
20 :  17
Kansas City Chiefs

Jan 26, 2025 - NFL

Buffalo Bills
29 :  32
Kansas City Chiefs
L L W L L L
Victories

1/6 (17%)

Draw

0/6 (0%)

Defeats

5/6 (83%)

Nov 16, 2025 - NFL

Kansas City Chiefs
19 :  22
Denver Broncos

Nov 2, 2025 - NFL

Kansas City Chiefs
21 :  28
Buffalo Bills

Oct 6, 2025 - NFL

Kansas City Chiefs
28 :  31
Jacksonville Jaguars

Sep 21, 2025 - NFL

Kansas City Chiefs
22 :  9
New York Giants

Sep 5, 2025 - NFL

Kansas City Chiefs
21 :  27
Los Angeles Chargers

Feb 9, 2025 - NFL

Kansas City Chiefs
22 :  40
Philadelphia Eagles

Indianapolis Colts against Kansas City Chiefs : Head to Head (H2H)

Jan 12, 2019 - NFL

Indianapolis Colts
13 :  31
Kansas City Chiefs

Indianapolis Colts - Kansas City Chiefs Key Points

  1. The Colts are averaging 32.1 points per game
  2. The Colts are allowing 20.6 points per game
  3. The Chiefs are averaging 25.4 points per game
  4. The Chiefs are allowing 18.1 points per game

Our Indianapolis Colts vs Kansas City Chiefs Prediction

Despite the Chiefs being in danger of making the playoffs, they are the favorites in this game against the red-hot Colts. Indianapolis is coming off a bye week after playing in Germany, where they beat the Atlanta Falcons in overtime and had an MVP-level performance from Jonathan Taylor.

Of course, this game is being played in Kansas City, which you think would give the Chiefs an advantage. However, teams seem to have figured out the Chiefs this season, and as a result, playing in Arrowhead is not as brutal as it normally would be.

Kansas City still has a solid offense and an excellent defense; however, the Colts are even better offensively and are just as good defensively. For that reason, our Kansas City Chiefs vs Indianapolis Colts prediction is: Indianapolis Colts +3.5.

Prediction:

 

Indianapolis Colts +3.5

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All tips are fully researched and given in good faith, but profits cannot be guaranteed.

Indianapolis Colts vs Kansas City Chiefs Picks