Arizona Cardinals vs Jacksonville Jaguars Prediction & Picks - NFL

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Arizona Cardinals
11/23/25 16:05
Jacksonville Jaguars

Prediction:

 

Arizona +3

-110
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 by Bill Christy | in NFL Picks

The Arizona Cardinals (3-7) will look to avoid another losing streak as they host the Jacksonville Jaguars (6-4) this Sunday afternoon. The Jags, on the other hand, are looking to keep some hope that they can steal the division over the current leaders, Indianapolis Colts.

The Cardinals finally snapped a 5-game losing streak 3 weeks ago when they defeated the Cowboys 27-17. Since then, they dropped both games. A 44-22 loss to Seattle was followed by a 41-22 loss to the Niners last week. They will once again be without Marvin Harrison Jr and Jacoby Brissett will be under center once again as Kyler Murray remains on the IR. If things are going to turn around at all for this Cardinals team, it is going to have to start with the defense that is now giving up over 25.5 points per game.

For the Jaguars, they are coming off a dominate win over the Los Angeles Chargers last week. The rushing game was stellar for the Jags as they posted nearly 200 yards on the ground in the 35-6 win. The defense was just as impressive, holding the Chargers to just 135 total yards and sacking Justin Herbert 3 times.

The Cardinals are going to be tested by this tough rushing attack of the Jaguars. If they are not up to the task, the result could be just as ugly as their last two games

Arizona Cardinals vs Jacksonville Jaguars Form

Table

Teams Pts P W L
4 Jacksonville Jaguars
0.765 17 13 4
30 Arizona Cardinals
0.176 17 3 14

Arizona Cardinals and Jacksonville Jaguars Latest Matches

Arizona Cardinals
Arizona Cardinals Latest matches
L L L W L L
Victories

1/6 (17%)

Defeats

5/6 (83%)

Nov 16, 2025 - NFL

Arizona Cardinals
22 :  41
San Francisco 49ers

Nov 9, 2025 - NFL

Seattle Seahawks
44 :  22
Arizona Cardinals

Nov 3, 2025 - NFL

Dallas Cowboys
17 :  27
Arizona Cardinals

Oct 19, 2025 - NFL

Arizona Cardinals
23 :  27
Green Bay Packers

Oct 12, 2025 - NFL

Indianapolis Colts
31 :  27
Arizona Cardinals

Oct 5, 2025 - NFL

Arizona Cardinals
21 :  22
Tennessee Titans
W W L L L L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Nov 16, 2025 - NFL

Arizona Cardinals
22 :  41
San Francisco 49ers

Oct 19, 2025 - NFL

Arizona Cardinals
23 :  27
Green Bay Packers

Oct 5, 2025 - NFL

Arizona Cardinals
21 :  22
Tennessee Titans

Sep 25, 2025 - NFL

Arizona Cardinals
20 :  23
Seattle Seahawks

Sep 14, 2025 - NFL

Arizona Cardinals
27 :  22
Carolina Panthers

Jan 5, 2025 - NFL

Arizona Cardinals
47 :  24
San Francisco 49ers
L W L L W L
Victories

2/6 (33%)

Defeats

4/6 (67%)

Nov 9, 2025 - NFL

Seattle Seahawks
44 :  22
Arizona Cardinals

Nov 3, 2025 - NFL

Dallas Cowboys
17 :  27
Arizona Cardinals

Oct 12, 2025 - NFL

Indianapolis Colts
31 :  27
Arizona Cardinals

Sep 21, 2025 - NFL

San Francisco 49ers
16 :  15
Arizona Cardinals

Sep 7, 2025 - NFL

New Orleans Saints
13 :  20
Arizona Cardinals

Dec 28, 2024 - NFL

Los Angeles Rams
13 :  9
Arizona Cardinals
Jacksonville Jaguars
Jacksonville Jaguars Latest matches
W L L W L W
Victories

3/6 (50%)

Defeats

3/6 (50%)

Nov 16, 2025 - NFL

Jacksonville Jaguars
35 :  6
Los Angeles Chargers

Nov 9, 2025 - NFL

Houston Texans
36 :  29
Jacksonville Jaguars

Nov 2, 2025 - NFL

Las Vegas Raiders
29 :  30
Jacksonville Jaguars

Oct 19, 2025 - NFL

Jacksonville Jaguars
7 :  35
Los Angeles Rams

Oct 12, 2025 - NFL

Jacksonville Jaguars
12 :  20
Seattle Seahawks

Oct 6, 2025 - NFL

Jacksonville Jaguars
31 :  28
Kansas City Chiefs
W W W L L W
Victories

4/6 (67%)

Defeats

2/6 (33%)

Nov 16, 2025 - NFL

Jacksonville Jaguars
35 :  6
Los Angeles Chargers

Oct 19, 2025 - NFL

Jacksonville Jaguars
7 :  35
Los Angeles Rams

Oct 12, 2025 - NFL

Jacksonville Jaguars
12 :  20
Seattle Seahawks

Oct 6, 2025 - NFL

Jacksonville Jaguars
31 :  28
Kansas City Chiefs

Sep 21, 2025 - NFL

Jacksonville Jaguars
17 :  10
Houston Texans

Sep 7, 2025 - NFL

Jacksonville Jaguars
26 :  10
Carolina Panthers
W L L W W L
Victories

3/6 (50%)

Defeats

3/6 (50%)

Nov 9, 2025 - NFL

Houston Texans
36 :  29
Jacksonville Jaguars

Nov 2, 2025 - NFL

Las Vegas Raiders
29 :  30
Jacksonville Jaguars

Sep 28, 2025 - NFL

San Francisco 49ers
21 :  26
Jacksonville Jaguars

Sep 14, 2025 - NFL

Cincinnati Bengals
31 :  27
Jacksonville Jaguars

Jan 5, 2025 - NFL

Indianapolis Colts
26 :  23
Jacksonville Jaguars

Dec 8, 2024 - NFL

Tennessee Titans
6 :  10
Jacksonville Jaguars

Arizona Cardinals against Jacksonville Jaguars : Head to Head (H2H)

Arizona Cardinals

100 %

Jacksonville Jaguars

0 %

Sep 26, 2021 - NFL

Jacksonville Jaguars
19 :  31
Arizona Cardinals
Arizona Cardinals vs Jacksonville Jaguars Picks

Arizona Cardinals - Jacksonville Jaguars Key Points

  1. Jacksonville is 1-4 ATS in its last 5 games.
  2. Jacksonville is 2-19 ATS in its last 21 games against an opponent in the NFC West.
  3. Arizona is 4-1 ATS in its last 5 games against Jacksonville.
  4. Arizona is 9-3 ATS in its last 12 games when playing as the underdog.

Our Arizona Cardinals vs Jacksonville Jaguars Prediction

This spread looks so trappy. How are the Jaguars being set as less than a field goal favorite in this one? The Jags just dismantled a decent Chargers team while this Cardinals team has looked like they are packing it in for the season. In a game where the spread should be closer to a touchdown, we smell something fishy. We are going to back the Cardinals here at home and wouldn’t be shocked if they somehow pull off the upset victory.

Our prediction for Arizona Cardinals vs Jacksonville Jaguars: Arizona +3

Prediction:

 

Arizona +3

-110
$150 offered for betting!

All tips are fully researched and given in good faith, but profits cannot be guaranteed.