St. Louis Cardinals vs Houston Astros Prediction & Picks - MLB

Prediction published on 4/15/25, 4:18 PM  by Carlos Zabala | Modified on 2/11/26 at 8:40 AM in MLB Picks

Game 2 between the Astros and Cardinals on Tuesday in Houston has the Astros as slight favorites at -130 odds, with Hunter Brown starting for them and Erick Fedde for the Cardinals.

The Astros also closed the pre-Game 1 betting round as a -115 favorite but ended up losing 3-8. The Astros have already lost more games as favorites in 2025 than they have won, with a 4-6 record. Meanwhile, the Cardinals are one of the most lucrative underdogs in MLB, with a 7-4 record in those games.

Arenado is batting 280 to start 2025 and hit his second home run of the season in the bottom of the seventh inning, but in Monday's 8-3 win, it was Donovan, batting in the bottom of the lineup, who had the better game, going 4-for-4 and scoring two runs in a game where the Cards allowed 14 hits.

Erick Fedde is coming off a strong start against the Pirates at PNC Park, where he pitched six scoreless innings on 88 pitches. However, his offense didn't back him up, and the Cardinals would end up losing their last outing 2-1.